SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y1x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_B_ANWB99_0
(PROTEIN S100-A13)		 1y1x LEISHMANIA MAJOR
HOMOLOG OF
PROGRAMMED CELL
DEATH 6 PROTEIN
(Leishmania
major) 		4 / 8 VAL A 176
THR A 177
PHE A 178
THR A 179
 None
 1.21A 2kotB-1y1xA:
5.1		 2kotB-1y1xA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 1y1x LEISHMANIA MAJOR
HOMOLOG OF
PROGRAMMED CELL
DEATH 6 PROTEIN
(Leishmania
major) 		3 / 3 ARG A 162
GLU A 153
SER A 121
 None
 0.86A 2xkkA-1y1xA:
undetectable
2xkkC-1y1xA:
undetectable		 2xkkA-1y1xA:
12.17
2xkkC-1y1xA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KD5_E_PPFE914_1
(DNA POLYMERASE)		 1y1x LEISHMANIA MAJOR
HOMOLOG OF
PROGRAMMED CELL
DEATH 6 PROTEIN
(Leishmania
major) 		4 / 5 ASP A 107
LEU A 110
ARG A 143
ASP A 103
 None
 1.44A 3kd5E-1y1xA:
0.3		 3kd5E-1y1xA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 1y1x LEISHMANIA MAJOR
HOMOLOG OF
PROGRAMMED CELL
DEATH 6 PROTEIN
(Leishmania
major) 		3 / 3 VAL A 126
SER A 127
THR A 130
 None
 0.44A 4luhA-1y1xA:
undetectable		 4luhA-1y1xA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 1y1x LEISHMANIA MAJOR
HOMOLOG OF
PROGRAMMED CELL
DEATH 6 PROTEIN
(Leishmania
major) 		4 / 7 VAL A  46
LEU A  62
SER A  61
GLU A 153
 None
SO4  A 203 (-4.6A)
SO4  A 203 (-2.4A)
None
 0.80A 4zphA-1y1xA:
undetectable
4zphB-1y1xA:
undetectable		 4zphA-1y1xA:
19.95
4zphB-1y1xA:
17.91