SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y23'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1y23 HISTIDINE TRIAD
PROTEIN
(Bacillus
subtilis) 		5 / 12 LEU A  43
HIS A 104
ASP A  33
GLY A  95
PHE A   9
 None
 1.26A 1d4fB-1y23A:
undetectable		 1d4fB-1y23A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1y23 HISTIDINE TRIAD
PROTEIN
(Bacillus
subtilis) 		5 / 12 LEU A  43
HIS A 104
ASP A  33
GLY A  95
PHE A   9
 None
 1.32A 1d4fD-1y23A:
undetectable		 1d4fD-1y23A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_1
(ADENOSYLHOMOCYSTEINA
SE)		 1y23 HISTIDINE TRIAD
PROTEIN
(Bacillus
subtilis) 		5 / 12 LEU A  43
HIS A 104
ASP A  33
GLY A  95
PHE A   9
 None
 1.15A 1xwfA-1y23A:
undetectable		 1xwfA-1y23A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_1
(ADENOSYLHOMOCYSTEINA
SE)		 1y23 HISTIDINE TRIAD
PROTEIN
(Bacillus
subtilis) 		5 / 12 LEU A  43
HIS A 104
ASP A  33
GLY A  95
PHE A   9
 None
 1.16A 1xwfB-1y23A:
undetectable		 1xwfB-1y23A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_1
(ADENOSYLHOMOCYSTEINA
SE)		 1y23 HISTIDINE TRIAD
PROTEIN
(Bacillus
subtilis) 		5 / 12 LEU A  43
HIS A 104
ASP A  33
GLY A  95
PHE A   9
 None
 1.13A 1xwfC-1y23A:
undetectable		 1xwfC-1y23A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_1
(ADENOSYLHOMOCYSTEINA
SE)		 1y23 HISTIDINE TRIAD
PROTEIN
(Bacillus
subtilis) 		5 / 12 LEU A  43
HIS A 104
ASP A  33
GLY A  95
PHE A   9
 None
 1.14A 1xwfD-1y23A:
undetectable		 1xwfD-1y23A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 1y23 HISTIDINE TRIAD
PROTEIN
(Bacillus
subtilis) 		5 / 12 LEU A  43
HIS A 104
ASP A  33
GLY A  95
PHE A   9
 None
 1.33A 3g1uA-1y23A:
undetectable		 3g1uA-1y23A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 1y23 HISTIDINE TRIAD
PROTEIN
(Bacillus
subtilis) 		5 / 12 LEU A  43
HIS A 104
GLN A  96
ASP A  33
GLY A  95
 None
 1.22A 3g1uB-1y23A:
undetectable		 3g1uB-1y23A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 1y23 HISTIDINE TRIAD
PROTEIN
(Bacillus
subtilis) 		5 / 12 LEU A  43
HIS A 104
ASP A  33
GLY A  95
PHE A   9
 None
 1.19A 3g1uD-1y23A:
undetectable		 3g1uD-1y23A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1y23 HISTIDINE TRIAD
PROTEIN
(Bacillus
subtilis) 		5 / 12 LEU A  43
HIS A 104
ASP A  33
GLY A  95
PHE A   9
 None
 1.20A 3n58A-1y23A:
undetectable		 3n58A-1y23A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 1y23 HISTIDINE TRIAD
PROTEIN
(Bacillus
subtilis) 		8 / 10 ILE A   8
PHE A   9
ILE A  12
ASP A  33
LEU A  43
SER A  97
HIS A 102
HIS A 104
 None
 0.52A 3o1cA-1y23A:
15.3		 3o1cA-1y23A:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 1y23 HISTIDINE TRIAD
PROTEIN
(Bacillus
subtilis) 		7 / 10 ILE A   8
PHE A   9
ILE A  12
ASP A  33
SER A  35
HIS A 102
HIS A 104
 None
 0.65A 3o1cA-1y23A:
15.3		 3o1cA-1y23A:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 1y23 HISTIDINE TRIAD
PROTEIN
(Bacillus
subtilis) 		8 / 10 PHE A   9
ILE A  12
ASP A  33
ILE A  34
LEU A  43
SER A  97
HIS A 102
HIS A 104
 None
 0.58A 3o1cA-1y23A:
15.3		 3o1cA-1y23A:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 1y23 HISTIDINE TRIAD
PROTEIN
(Bacillus
subtilis) 		7 / 10 PHE A   9
ILE A  12
ASP A  33
ILE A  34
SER A  35
HIS A 102
HIS A 104
 None
 0.75A 3o1cA-1y23A:
15.3		 3o1cA-1y23A:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 1y23 HISTIDINE TRIAD
PROTEIN
(Bacillus
subtilis) 		9 / 10 ILE A   8
PHE A   9
ILE A  12
ASP A  33
SER A  35
LEU A  43
SER A  97
HIS A 102
HIS A 104
 None
 0.68A 3o1xA-1y23A:
15.4		 3o1xA-1y23A:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 1y23 HISTIDINE TRIAD
PROTEIN
(Bacillus
subtilis) 		9 / 10 PHE A   9
ILE A  12
ASP A  33
ILE A  34
SER A  35
LEU A  43
SER A  97
HIS A 102
HIS A 104
 None
 0.70A 3o1xA-1y23A:
15.4		 3o1xA-1y23A:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 1y23 HISTIDINE TRIAD
PROTEIN
(Bacillus
subtilis) 		9 / 10 ILE A   8
PHE A   9
ILE A  12
ASP A  33
SER A  35
LEU A  43
SER A  97
HIS A 102
HIS A 104
 None
 0.71A 3qgzA-1y23A:
15.5		 3qgzA-1y23A:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 1y23 HISTIDINE TRIAD
PROTEIN
(Bacillus
subtilis) 		9 / 10 PHE A   9
ILE A  12
ASP A  33
ILE A  34
SER A  35
LEU A  43
SER A  97
HIS A 102
HIS A 104
 None
 0.69A 3qgzA-1y23A:
15.5		 3qgzA-1y23A:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1y23 HISTIDINE TRIAD
PROTEIN
(Bacillus
subtilis) 		5 / 12 LEU A  43
HIS A 104
ASP A  33
GLY A  95
PHE A   9
 None
 1.23A 4pfjA-1y23A:
undetectable		 4pfjA-1y23A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1y23 HISTIDINE TRIAD
PROTEIN
(Bacillus
subtilis) 		5 / 12 LEU A  43
HIS A 104
ASP A  33
GLY A  95
PHE A   9
 None
 1.21A 5axaC-1y23A:
undetectable		 5axaC-1y23A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 1y23 HISTIDINE TRIAD
PROTEIN
(Bacillus
subtilis) 		3 / 3 ILE A  17
PRO A  18
ILE A  12
 None
 0.41A 5hw8F-1y23A:
undetectable		 5hw8F-1y23A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 1y23 HISTIDINE TRIAD
PROTEIN
(Bacillus
subtilis) 		5 / 8 ASN A  89
GLN A  96
SER A  97
HIS A 102
HIS A 104
 None
 0.55A 5km8A-1y23A:
12.3
5km8B-1y23A:
15.3		 5km8A-1y23A:
24.07
5km8B-1y23A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 1y23 HISTIDINE TRIAD
PROTEIN
(Bacillus
subtilis) 		7 / 12 PHE A   9
ILE A  12
ASP A  33
LEU A  43
VAL A  98
HIS A 102
HIS A 104
 None
 0.38A 5km9B-1y23A:
15.4		 5km9B-1y23A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1y23 HISTIDINE TRIAD
PROTEIN
(Bacillus
subtilis) 		5 / 12 LEU A  43
HIS A 104
ASP A  33
GLY A  95
PHE A   9
 None
 1.20A 5m5kA-1y23A:
undetectable		 5m5kA-1y23A:
15.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 1y23 HISTIDINE TRIAD
PROTEIN
(Bacillus
subtilis) 		8 / 12 PHE A   9
ILE A  12
ASP A  33
ILE A  34
LEU A  43
VAL A  98
HIS A 102
HIS A 104
 None
 0.48A 5uvmB-1y23A:
15.5		 5uvmB-1y23A:
30.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 1y23 HISTIDINE TRIAD
PROTEIN
(Bacillus
subtilis) 		5 / 12 LEU A  43
HIS A 104
ASP A  33
GLY A  95
PHE A   9
 None
 1.24A 5v96B-1y23A:
undetectable		 5v96B-1y23A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1y23 HISTIDINE TRIAD
PROTEIN
(Bacillus
subtilis) 		5 / 12 LEU A  43
HIS A 104
ASP A  33
GLY A  95
PHE A   9
 None
 1.23A 6aphA-1y23A:
undetectable		 6aphA-1y23A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_1
(-)		 1y23 HISTIDINE TRIAD
PROTEIN
(Bacillus
subtilis) 		5 / 12 LEU A  43
HIS A 104
ASP A  33
GLY A  95
PHE A   9
 None
 1.23A 6gbnA-1y23A:
undetectable		 6gbnA-1y23A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_1
(-)		 1y23 HISTIDINE TRIAD
PROTEIN
(Bacillus
subtilis) 		5 / 12 LEU A  43
HIS A 104
ASP A  33
GLY A  95
PHE A   9
 None
 1.23A 6gbnB-1y23A:
undetectable		 6gbnB-1y23A:
16.26