SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y25'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		4 / 8 PRO A  53
THR A  57
PRO A  58
ARG A 130
 None
ACT  A1200 (-3.6A)
ACT  A1200 (-3.6A)
ACT  A1200 (-3.1A)
 0.54A 1h4oB-1y25A:
19.2		 1h4oB-1y25A:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		4 / 8 PRO A  53
THR A  57
PRO A  58
ARG A 130
 None
ACT  A1200 (-3.6A)
ACT  A1200 (-3.6A)
ACT  A1200 (-3.1A)
 0.49A 1h4oG-1y25A:
19.0		 1h4oG-1y25A:
29.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		4 / 8 PRO A  53
THR A  57
PRO A  58
ARG A 130
 None
ACT  A1200 (-3.6A)
ACT  A1200 (-3.6A)
ACT  A1200 (-3.1A)
 0.53A 1oc3A-1y25A:
19.2		 1oc3A-1y25A:
30.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		5 / 12 THR A  30
SER A 105
LEU A 128
VAL A 117
VAL A  81
 None
 1.16A 1q23C-1y25A:
undetectable		 1q23C-1y25A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		5 / 11 THR A  30
SER A 105
LEU A 128
VAL A 117
VAL A  81
 None
 1.18A 1q23L-1y25A:
undetectable		 1q23L-1y25A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		4 / 7 GLY A  35
ARG A 108
ILE A  37
VAL A  36
 None
 1.04A 1rxcD-1y25A:
undetectable		 1rxcD-1y25A:
25.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1URM_A_BEZA201_0
(PEROXIREDOXIN 5)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		5 / 9 PRO A  53
THR A  57
PRO A  58
SER A  60
ARG A 130
 None
ACT  A1200 (-3.6A)
ACT  A1200 (-3.6A)
ACT  A1200 (-2.8A)
ACT  A1200 (-3.1A)
 0.50A 1urmA-1y25A:
19.1		 1urmA-1y25A:
30.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1URM_A_BEZA201_0
(PEROXIREDOXIN 5)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		5 / 9 PRO A  53
THR A  57
PRO A  58
SER A  60
LEU A   6
 None
ACT  A1200 (-3.6A)
ACT  A1200 (-3.6A)
ACT  A1200 (-2.8A)
None
 1.10A 1urmA-1y25A:
19.1		 1urmA-1y25A:
30.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		5 / 7 THR A  57
PRO A  58
VAL A  59
SER A  60
ARG A 130
 ACT  A1200 (-3.6A)
ACT  A1200 (-3.6A)
ACT  A1200 (-3.7A)
ACT  A1200 (-2.8A)
ACT  A1200 (-3.1A)
 0.32A 2v2gA-1y25A:
16.5
2v2gB-1y25A:
16.4		 2v2gA-1y25A:
25.11
2v2gB-1y25A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		5 / 7 THR A  57
PRO A  58
VAL A  59
SER A  60
ARG A 130
 ACT  A1200 (-3.6A)
ACT  A1200 (-3.6A)
ACT  A1200 (-3.7A)
ACT  A1200 (-2.8A)
ACT  A1200 (-3.1A)
 0.30A 2v2gA-1y25A:
16.5
2v2gB-1y25A:
16.4		 2v2gA-1y25A:
25.11
2v2gB-1y25A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		5 / 7 THR A  57
PRO A  58
VAL A  59
SER A  60
ARG A 130
 ACT  A1200 (-3.6A)
ACT  A1200 (-3.6A)
ACT  A1200 (-3.7A)
ACT  A1200 (-2.8A)
ACT  A1200 (-3.1A)
 0.30A 2v2gC-1y25A:
16.4
2v2gD-1y25A:
16.5		 2v2gC-1y25A:
25.11
2v2gD-1y25A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		5 / 7 THR A  57
PRO A  58
VAL A  59
SER A  60
ARG A 130
 ACT  A1200 (-3.6A)
ACT  A1200 (-3.6A)
ACT  A1200 (-3.7A)
ACT  A1200 (-2.8A)
ACT  A1200 (-3.1A)
 0.32A 2v2gC-1y25A:
16.4
2v2gD-1y25A:
16.5		 2v2gC-1y25A:
25.11
2v2gD-1y25A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		5 / 8 THR A  57
PRO A  58
VAL A  59
SER A  60
ARG A 130
 ACT  A1200 (-3.6A)
ACT  A1200 (-3.6A)
ACT  A1200 (-3.7A)
ACT  A1200 (-2.8A)
ACT  A1200 (-3.1A)
 0.26A 2v32A-1y25A:
16.3
2v32B-1y25A:
16.4		 2v32A-1y25A:
25.11
2v32B-1y25A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		5 / 8 THR A  57
PRO A  58
VAL A  59
SER A  60
ARG A 130
 ACT  A1200 (-3.6A)
ACT  A1200 (-3.6A)
ACT  A1200 (-3.7A)
ACT  A1200 (-2.8A)
ACT  A1200 (-3.1A)
 0.31A 2v32A-1y25A:
16.3
2v32B-1y25A:
16.4		 2v32A-1y25A:
25.11
2v32B-1y25A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		6 / 8 PRO A  53
THR A  57
PRO A  58
VAL A  59
SER A  60
ARG A 130
 None
ACT  A1200 (-3.6A)
ACT  A1200 (-3.6A)
ACT  A1200 (-3.7A)
ACT  A1200 (-2.8A)
ACT  A1200 (-3.1A)
 0.42A 2v32C-1y25A:
16.6
2v32D-1y25A:
17.4		 2v32C-1y25A:
25.11
2v32D-1y25A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		5 / 8 THR A  57
PRO A  58
VAL A  59
SER A  60
ARG A 130
 ACT  A1200 (-3.6A)
ACT  A1200 (-3.6A)
ACT  A1200 (-3.7A)
ACT  A1200 (-2.8A)
ACT  A1200 (-3.1A)
 0.32A 2v32C-1y25A:
16.6
2v32D-1y25A:
17.4		 2v32C-1y25A:
25.11
2v32D-1y25A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_A_BEZA1222_0
(PEROXIREDOXIN 6.)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		6 / 9 PRO A  53
THR A  57
PRO A  58
VAL A  59
SER A  60
ARG A 130
 None
ACT  A1200 (-3.6A)
ACT  A1200 (-3.6A)
ACT  A1200 (-3.7A)
ACT  A1200 (-2.8A)
ACT  A1200 (-3.1A)
 0.42A 2v41A-1y25A:
16.4
2v41B-1y25A:
16.5		 2v41A-1y25A:
25.11
2v41B-1y25A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_B_BEZB1222_0
(PEROXIREDOXIN 6.)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		6 / 9 PRO A  53
THR A  57
PRO A  58
VAL A  59
SER A  60
ARG A 130
 None
ACT  A1200 (-3.6A)
ACT  A1200 (-3.6A)
ACT  A1200 (-3.7A)
ACT  A1200 (-2.8A)
ACT  A1200 (-3.1A)
 0.42A 2v41A-1y25A:
16.4
2v41B-1y25A:
16.5		 2v41A-1y25A:
25.11
2v41B-1y25A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		6 / 8 PRO A  53
THR A  57
PRO A  58
VAL A  59
SER A  60
ARG A 130
 None
ACT  A1200 (-3.6A)
ACT  A1200 (-3.6A)
ACT  A1200 (-3.7A)
ACT  A1200 (-2.8A)
ACT  A1200 (-3.1A)
 0.45A 2v41C-1y25A:
17.3
2v41D-1y25A:
17.4		 2v41C-1y25A:
25.11
2v41D-1y25A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		6 / 8 PRO A  53
THR A  57
PRO A  58
VAL A  59
SER A  60
ARG A 130
 None
ACT  A1200 (-3.6A)
ACT  A1200 (-3.6A)
ACT  A1200 (-3.7A)
ACT  A1200 (-2.8A)
ACT  A1200 (-3.1A)
 0.45A 2v41C-1y25A:
17.3
2v41D-1y25A:
17.4		 2v41C-1y25A:
25.11
2v41D-1y25A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		5 / 7 THR A  57
PRO A  58
VAL A  59
SER A  60
ARG A 130
 ACT  A1200 (-3.6A)
ACT  A1200 (-3.6A)
ACT  A1200 (-3.7A)
ACT  A1200 (-2.8A)
ACT  A1200 (-3.1A)
 0.29A 2v41E-1y25A:
16.3
2v41F-1y25A:
16.2		 2v41E-1y25A:
25.11
2v41F-1y25A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		5 / 7 THR A  57
PRO A  58
VAL A  59
SER A  60
ARG A 130
 ACT  A1200 (-3.6A)
ACT  A1200 (-3.6A)
ACT  A1200 (-3.7A)
ACT  A1200 (-2.8A)
ACT  A1200 (-3.1A)
 0.31A 2v41E-1y25A:
16.3
2v41F-1y25A:
16.2		 2v41E-1y25A:
25.11
2v41F-1y25A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		5 / 8 THR A  57
PRO A  58
VAL A  59
SER A  60
ARG A 130
 ACT  A1200 (-3.6A)
ACT  A1200 (-3.6A)
ACT  A1200 (-3.7A)
ACT  A1200 (-2.8A)
ACT  A1200 (-3.1A)
 0.29A 2v41G-1y25A:
16.5
2v41H-1y25A:
16.5		 2v41G-1y25A:
25.11
2v41H-1y25A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		6 / 8 PRO A  53
THR A  57
PRO A  58
VAL A  59
SER A  60
ARG A 130
 None
ACT  A1200 (-3.6A)
ACT  A1200 (-3.6A)
ACT  A1200 (-3.7A)
ACT  A1200 (-2.8A)
ACT  A1200 (-3.1A)
 0.42A 2v41G-1y25A:
16.6
2v41H-1y25A:
16.5		 2v41G-1y25A:
25.11
2v41H-1y25A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		4 / 8 SER A  39
VAL A 117
TYR A 115
VAL A  81
 None
 1.32A 2y05A-1y25A:
undetectable
2y05B-1y25A:
undetectable		 2y05A-1y25A:
20.73
2y05B-1y25A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		4 / 6 GLY A  35
ARG A 108
ILE A  37
VAL A  36
 None
 1.06A 3kvvB-1y25A:
undetectable		 3kvvB-1y25A:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 147
VAL A  59
SER A  63
 None
ACT  A1200 (-3.7A)
None
 0.57A 3n8xB-1y25A:
undetectable		 3n8xB-1y25A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		4 / 8 ARG A  91
VAL A 101
ASP A  84
GLN A  89
 None
 1.08A 3uy4A-1y25A:
2.0		 3uy4A-1y25A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		3 / 3 ASP A  68
GLU A  99
GLY A  97
 None
 0.62A 3w9tA-1y25A:
undetectable		 3w9tA-1y25A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		5 / 12 ASP A  56
VAL A  64
VAL A  59
SER A  54
THR A  98
 None
None
ACT  A1200 (-3.7A)
None
None
 0.95A 4mm4B-1y25A:
undetectable		 4mm4B-1y25A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  64
LEU A 160
ALA A 159
ASN A  50
ALA A  76
 None
 1.11A 4x1kA-1y25A:
undetectable
4x1kB-1y25A:
undetectable		 4x1kA-1y25A:
17.49
4x1kB-1y25A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		4 / 6 CYH A  93
GLY A  31
GLY A  32
ASP A  33
 None
 0.87A 5a06D-1y25A:
undetectable		 5a06D-1y25A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		5 / 12 PHE A  27
GLY A 116
GLY A 112
THR A 118
LEU A  17
 None
 1.17A 5kocB-1y25A:
undetectable		 5kocB-1y25A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 1y25 PROBABLE THIOL
PEROXIDASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A  48
ALA A 159
GLU A  96
VAL A 147
ARG A 130
 None
None
None
None
ACT  A1200 (-3.1A)
 1.33A 6b89A-1y25A:
0.0		 6b89A-1y25A:
22.30