SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y2i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Q63_A_1UNA1001_1 (PROTEASE RETROPEPSIN)	1y2i	HYPOTHETICAL PROTEIN S0862 (Shigella flexneri)	6 / 12	GLY A 73 ALA A 74 ASP A 75 VAL A 78 ILE A 14 VAL A 20	None	1.47A	2q63A-1y2iA: undetectable	2q63A-1y2iA: 21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MM4_A_8PRA603_1 (TRANSPORTER)	1y2i	HYPOTHETICAL PROTEIN S0862 (Shigella flexneri)	5 / 12	ASP A 81 TYR A 84 PHE A 62 SER A 99 GLY A 23	None	1.20A	4mm4A-1y2iA: undetectable	4mm4A-1y2iA: 13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MM4_B_8PRB603_1 (TRANSPORTER)	1y2i	HYPOTHETICAL PROTEIN S0862 (Shigella flexneri)	5 / 12	ASP A 81 TYR A 84 PHE A 62 SER A 99 GLY A 23	None	1.20A	4mm4B-1y2iA: undetectable	4mm4B-1y2iA: 13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MMC_A_29JA603_1 (TRANSPORTER)	1y2i	HYPOTHETICAL PROTEIN S0862 (Shigella flexneri)	5 / 10	ASP A 81 TYR A 84 PHE A 62 SER A 99 GLY A 23	None	1.24A	4mmcA-1y2iA: undetectable	4mmcA-1y2iA: 14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XP4_A_COCA706_1 (DOPAMINE TRANSPORTER)	1y2i	HYPOTHETICAL PROTEIN S0862 (Shigella flexneri)	5 / 11	ASP A 81 TYR A 84 PHE A 62 SER A 99 GLY A 23	None	1.19A	4xp4A-1y2iA: undetectable	4xp4A-1y2iA: 12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XPB_A_COCA702_1 (TRANSPORTER)	1y2i	HYPOTHETICAL PROTEIN S0862 (Shigella flexneri)	5 / 10	ASP A 81 TYR A 84 PHE A 62 SER A 99 GLY A 23	None	1.21A	4xpbA-1y2iA: undetectable	4xpbA-1y2iA: 12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5B2S_A_ACTA107_0 (CRISPR-ASSOCIATED ENDONUCLEASE CAS9 GUIDE RNA)	1y2i	HYPOTHETICAL PROTEIN S0862 (Shigella flexneri)	3 / 3	VAL A 15 THR A 13 ARG A 106	None	0.74A	5b2sB-1y2iA: undetectable	5b2sB-1y2iA: 7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5B2T_A_ACTA108_0 (CRISPR-ASSOCIATED ENDONUCLEASE CAS9 GUIDE RNA)	1y2i	HYPOTHETICAL PROTEIN S0862 (Shigella flexneri)	3 / 3	VAL A 15 THR A 13 ARG A 106	None	0.78A	5b2tB-1y2iA: undetectable	5b2tB-1y2iA: 7.24

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2Q63_A_1UNA1001_1","PROTEASE RETROPEPSIN","1y2i","HYPOTHETICAL PROTEIN S0862","Shigella flexneri",6,"GLY A  73;ALA A  74;ASP A  75;VAL A  78;ILE A  14;VAL A  20","None","1.47A","2q63A-1y2iA:undetectable","2q63A-1y2iA:21.05"],["4MM4_A_8PRA603_1","TRANSPORTER","1y2i","HYPOTHETICAL PROTEIN S0862","Shigella flexneri",5,"ASP A  81;TYR A  84;PHE A  62;SER A  99;GLY A  23","None","1.20A","4mm4A-1y2iA:undetectable","4mm4A-1y2iA:13.33"],["4MM4_B_8PRB603_1","TRANSPORTER","1y2i","HYPOTHETICAL PROTEIN S0862","Shigella flexneri",5,"ASP A  81;TYR A  84;PHE A  62;SER A  99;GLY A  23","None","1.20A","4mm4B-1y2iA:undetectable","4mm4B-1y2iA:13.33"],["4MMC_A_29JA603_1","TRANSPORTER","1y2i","HYPOTHETICAL PROTEIN S0862","Shigella flexneri",5,"ASP A  81;TYR A  84;PHE A  62;SER A  99;GLY A  23","None","1.24A","4mmcA-1y2iA:undetectable","4mmcA-1y2iA:14.51"],["4XP4_A_COCA706_1","DOPAMINE TRANSPORTER","1y2i","HYPOTHETICAL PROTEIN S0862","Shigella flexneri",5,"ASP A  81;TYR A  84;PHE A  62;SER A  99;GLY A  23","None","1.19A","4xp4A-1y2iA:undetectable","4xp4A-1y2iA:12.95"],["4XPB_A_COCA702_1","TRANSPORTER","1y2i","HYPOTHETICAL PROTEIN S0862","Shigella flexneri",5,"ASP A  81;TYR A  84;PHE A  62;SER A  99;GLY A  23","None","1.21A","4xpbA-1y2iA:undetectable","4xpbA-1y2iA:12.64"],["5B2S_A_ACTA107_0","CRISPR-ASSOCIATED ENDONUCLEASE CAS9;GUIDE RNA","1y2i","HYPOTHETICAL PROTEIN S0862","Shigella flexneri",3,"VAL A  15;THR A  13;ARG A 106","None","0.74A","5b2sB-1y2iA:undetectable","5b2sB-1y2iA:7.08"],["5B2T_A_ACTA108_0","CRISPR-ASSOCIATED ENDONUCLEASE CAS9;GUIDE RNA","1y2i","HYPOTHETICAL PROTEIN S0862","Shigella flexneri",3,"VAL A  15;THR A  13;ARG A 106","None","0.78A","5b2tB-1y2iA:undetectable","5b2tB-1y2iA:7.24"]]