SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y3n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		4 / 6 TRP A 270
TYR A 395
ILE A 385
TYR A 379
 BEM  A 494 ( 3.8A)
BEM  A 494 (-4.6A)
None
None
 1.15A 1maaB-1y3nA:
undetectable
1maaD-1y3nA:
undetectable		 1maaB-1y3nA:
21.56
1maaD-1y3nA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ND4_B_KANB2300_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		5 / 9 ASP A 269
ARG A 186
GLU A 306
ASP A 187
GLU A 189
 None
MAV  A 495 (-3.1A)
None
MAV  A 495 ( 4.4A)
None
 1.45A 1nd4B-1y3nA:
0.0		 1nd4B-1y3nA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		4 / 7 THR A 400
TYR A 363
LEU A 368
GLN A 398
 None
 1.09A 1qzrA-1y3nA:
undetectable		 1qzrA-1y3nA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		4 / 7 THR A 400
TYR A 363
LEU A 368
GLN A 398
 None
 1.11A 1qzrB-1y3nA:
undetectable		 1qzrB-1y3nA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		5 / 12 GLY A  84
GLY A  87
ASP A  78
ASP A  74
GLY A  73
 None
 1.04A 1sqfA-1y3nA:
undetectable		 1sqfA-1y3nA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		4 / 7 TYR A 393
ASP A 392
ASP A 132
HIS A 110
 None
 1.21A 1t03A-1y3nA:
undetectable		 1t03A-1y3nA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		5 / 12 ALA A 485
ARG A 488
ILE A  81
PHE A 211
PHE A 421
 None
 1.34A 1y0xX-1y3nA:
undetectable		 1y0xX-1y3nA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		3 / 3 SER A 202
GLU A 305
ASP A 269
 None
 0.65A 2avdB-1y3nA:
undetectable		 2avdB-1y3nA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_F_SAMF501_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		4 / 6 ASN A 278
ASN A 401
TRP A 399
TRP A 270
 None
None
None
BEM  A 494 ( 3.8A)
 1.11A 2c2bC-1y3nA:
0.0
2c2bE-1y3nA:
0.0
2c2bF-1y3nA:
0.0		 2c2bC-1y3nA:
20.53
2c2bE-1y3nA:
20.53
2c2bF-1y3nA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		4 / 5 ILE A 181
PRO A 182
PHE A 183
ILE A 247
 None
 1.16A 2hjhA-1y3nA:
undetectable		 2hjhA-1y3nA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		3 / 3 GLN A 236
LYS A 232
VAL A 453
 None
 0.84A 2jfaB-1y3nA:
undetectable		 2jfaB-1y3nA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		3 / 3 ASP A 187
ASN A 185
THR A 258
 MAV  A 495 ( 4.4A)
None
None
 0.68A 2q63B-1y3nA:
undetectable		 2q63B-1y3nA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		5 / 12 ILE A 141
TYR A 139
LEU A 164
PHE A 197
PRO A 154
 None
 1.17A 2y7kD-1y3nA:
4.1		 2y7kD-1y3nA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		4 / 5 LEU A 160
ILE A 184
ARG A 250
TYR A 139
 None
 1.27A 2zlcA-1y3nA:
0.0		 2zlcA-1y3nA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		5 / 12 MET A  17
ILE A  15
ALA A  32
VAL A  41
LEU A 332
 None
 1.07A 3a51E-1y3nA:
undetectable		 3a51E-1y3nA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		4 / 8 VAL A  35
GLY A 341
LYS A 340
ARG A  37
 None
 0.96A 3bjwA-1y3nA:
undetectable		 3bjwA-1y3nA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		3 / 3 SER A  54
GLN A  55
PHE A  58
 None
 0.68A 3g4lC-1y3nA:
undetectable		 3g4lC-1y3nA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		3 / 3 LYS A  77
SER A 205
GLN A 310
 None
 1.38A 3si7A-1y3nA:
undetectable		 3si7A-1y3nA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		5 / 12 MET A  17
ILE A  15
ALA A  32
ILE A 319
LEU A 332
 None
 1.07A 3vrmA-1y3nA:
undetectable		 3vrmA-1y3nA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		5 / 12 ILE A 184
LEU A 164
LEU A 160
ILE A 141
THR A 274
 None
 0.98A 4m2xC-1y3nA:
undetectable		 4m2xC-1y3nA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		3 / 3 LEU A 242
VAL A 157
ASP A 158
 None
 0.54A 4y8wC-1y3nA:
undetectable		 4y8wC-1y3nA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		4 / 7 ARG A  20
ARG A 255
ASP A 269
TYR A 379
 MAV  A 495 (-4.1A)
BEM  A 494 ( 4.8A)
None
None
 1.42A 5a06A-1y3nA:
undetectable		 5a06A-1y3nA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		4 / 7 ARG A 250
ASP A 244
ILE A 247
TYR A 238
 None
 0.98A 5a06B-1y3nA:
undetectable		 5a06B-1y3nA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		4 / 7 ARG A  20
ARG A 255
ASP A 269
TYR A 379
 MAV  A 495 (-4.1A)
BEM  A 494 ( 4.8A)
None
None
 1.41A 5a06C-1y3nA:
undetectable		 5a06C-1y3nA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		4 / 7 ARG A  20
ARG A 255
ASP A 269
TYR A 379
 MAV  A 495 (-4.1A)
BEM  A 494 ( 4.8A)
None
None
 1.41A 5a06D-1y3nA:
undetectable		 5a06D-1y3nA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		4 / 7 ARG A  20
ARG A 255
ASP A 269
TYR A 379
 MAV  A 495 (-4.1A)
BEM  A 494 ( 4.8A)
None
None
 1.42A 5a06E-1y3nA:
undetectable		 5a06E-1y3nA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		4 / 7 ARG A  20
ARG A 255
ASP A 269
TYR A 379
 MAV  A 495 (-4.1A)
BEM  A 494 ( 4.8A)
None
None
 1.39A 5a06F-1y3nA:
undetectable		 5a06F-1y3nA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		4 / 6 THR A 203
GLY A 204
GLU A 306
PHE A 421
 None
 0.94A 5kmfA-1y3nA:
2.8
5kmfC-1y3nA:
3.8		 5kmfA-1y3nA:
20.77
5kmfC-1y3nA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		5 / 9 LEU A 332
VAL A  41
ILE A  15
ILE A  70
ASP A  69
 None
 1.16A 5yf9X-1y3nA:
undetectable		 5yf9X-1y3nA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		4 / 4 GLY A 260
ARG A 142
ASN A 262
LEU A 281
 None
 1.08A 6b58A-1y3nA:
2.7		 6b58A-1y3nA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		4 / 5 TYR A 393
GLN A 391
GLY A 138
ILE A 408
 None
BEM  A 494 (-3.6A)
None
None
 1.39A 6debB-1y3nA:
undetectable		 6debB-1y3nA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		5 / 12 LEU A  92
ILE A 124
ILE A 330
ASP A  97
ILE A  96
 None
 0.96A 6emuA-1y3nA:
undetectable		 6emuA-1y3nA:
16.94