SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y3t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		4 / 6 GLY A  54
ASP A  57
GLY A  29
SER A  52
 None
 0.79A 1eswA-1y3tA:
undetectable		 1eswA-1y3tA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		4 / 6 GLY A  54
ASP A  57
TYR A 142
SER A  52
 None
 0.83A 1eswA-1y3tA:
undetectable		 1eswA-1y3tA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		4 / 4 THR A  34
LEU A  50
VAL A 115
LEU A  72
 None
 1.08A 1fbmB-1y3tA:
undetectable		 1fbmB-1y3tA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		4 / 4 THR A  34
LEU A  50
VAL A 115
LEU A  72
 None
 0.98A 1mz9D-1y3tA:
undetectable		 1mz9D-1y3tA:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		4 / 4 HIS A 103
GLU A  69
HIS A  64
HIS A  62
 FE  A 401 (-3.5A)
FE  A 401 (-2.6A)
FE  A 401 (-3.3A)
FE  A 401 (-3.6A)
 1.13A 1os2D-1y3tA:
undetectable		 1os2D-1y3tA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		4 / 8 ASN A  96
PHE A 218
SER A 116
ALA A 209
 None
 0.94A 1rqpA-1y3tA:
undetectable		 1rqpA-1y3tA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		3 / 3 SER A  20
GLY A 264
ARG A 111
 None
 0.62A 1t9wA-1y3tA:
0.0		 1t9wA-1y3tA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		4 / 4 HIS A 103
GLU A  69
HIS A  64
HIS A  62
 FE  A 401 (-3.5A)
FE  A 401 (-2.6A)
FE  A 401 (-3.3A)
FE  A 401 (-3.6A)
 1.15A 1utzA-1y3tA:
undetectable		 1utzA-1y3tA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		4 / 4 HIS A 103
GLU A  69
HIS A  64
HIS A  62
 FE  A 401 (-3.5A)
FE  A 401 (-2.6A)
FE  A 401 (-3.3A)
FE  A 401 (-3.6A)
 1.17A 1utzB-1y3tA:
undetectable		 1utzB-1y3tA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		4 / 8 TYR A 127
HIS A  64
GLU A  69
HIS A 103
 None
FE  A 401 (-3.3A)
FE  A 401 (-2.6A)
FE  A 401 (-3.5A)
 1.03A 2bnnA-1y3tA:
8.7
2bnnB-1y3tA:
8.8		 2bnnA-1y3tA:
22.43
2bnnB-1y3tA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		4 / 7 VAL A  49
SER A 116
LEU A 126
HIS A  62
 None
None
None
FE  A 401 (-3.6A)
 1.14A 2f78B-1y3tA:
undetectable		 2f78B-1y3tA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		3 / 3 ARG A 206
GLY A 225
PRO A 226
 None
 0.60A 2hreD-1y3tA:
undetectable		 2hreD-1y3tA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		4 / 4 HIS A 103
GLU A  69
HIS A  64
HIS A  62
 FE  A 401 (-3.5A)
FE  A 401 (-2.6A)
FE  A 401 (-3.3A)
FE  A 401 (-3.6A)
 1.16A 2hu6A-1y3tA:
undetectable		 2hu6A-1y3tA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		5 / 6 LEU A  51
HIS A 103
GLU A  69
HIS A  64
HIS A  62
 None
FE  A 401 (-3.5A)
FE  A 401 (-2.6A)
FE  A 401 (-3.3A)
FE  A 401 (-3.6A)
 1.19A 2ow9A-1y3tA:
undetectable		 2ow9A-1y3tA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		4 / 4 HIS A 103
GLU A  69
HIS A  64
HIS A  62
 FE  A 401 (-3.5A)
FE  A 401 (-2.6A)
FE  A 401 (-3.3A)
FE  A 401 (-3.6A)
 1.14A 2ow9B-1y3tA:
undetectable		 2ow9B-1y3tA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		4 / 4 HIS A 103
GLU A  69
HIS A  64
HIS A  62
 FE  A 401 (-3.5A)
FE  A 401 (-2.6A)
FE  A 401 (-3.3A)
FE  A 401 (-3.6A)
 1.15A 2ozrC-1y3tA:
undetectable		 2ozrC-1y3tA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		4 / 4 HIS A 103
GLU A  69
HIS A  64
HIS A  62
 FE  A 401 (-3.5A)
FE  A 401 (-2.6A)
FE  A 401 (-3.3A)
FE  A 401 (-3.6A)
 1.13A 2ozrD-1y3tA:
undetectable		 2ozrD-1y3tA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		4 / 4 HIS A 103
GLU A  69
HIS A  64
HIS A  62
 FE  A 401 (-3.5A)
FE  A 401 (-2.6A)
FE  A 401 (-3.3A)
FE  A 401 (-3.6A)
 1.26A 2ozrE-1y3tA:
undetectable		 2ozrE-1y3tA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		4 / 4 HIS A 103
GLU A  69
HIS A  64
HIS A  62
 FE  A 401 (-3.5A)
FE  A 401 (-2.6A)
FE  A 401 (-3.3A)
FE  A 401 (-3.6A)
 1.19A 3lilA-1y3tA:
undetectable		 3lilA-1y3tA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		4 / 7 THR A 118
HIS A  62
ILE A  97
HIS A  64
 None
FE  A 401 (-3.6A)
None
FE  A 401 (-3.3A)
 1.04A 3t01A-1y3tA:
undetectable		 3t01A-1y3tA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		4 / 5 LEU A  51
HIS A 103
GLU A  69
HIS A  64
 None
FE  A 401 (-3.5A)
FE  A 401 (-2.6A)
FE  A 401 (-3.3A)
 1.05A 4a7bB-1y3tA:
undetectable		 4a7bB-1y3tA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		4 / 8 GLY A 288
VAL A 289
PHE A 299
ILE A 207
 None
 0.94A 4fglD-1y3tA:
undetectable		 4fglD-1y3tA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		4 / 5 PRO A  98
GLY A 100
ASP A  93
ASP A  83
 None
 1.04A 4n48B-1y3tA:
undetectable		 4n48B-1y3tA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		4 / 4 ASN A  38
SER A 128
ALA A 124
VAL A 123
 None
 1.35A 4x1kC-1y3tA:
undetectable		 4x1kC-1y3tA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		3 / 3 LEU A 204
ASP A 202
ILE A 207
 None
 0.67A 4xi3D-1y3tA:
undetectable		 4xi3D-1y3tA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		5 / 12 GLY A 288
SER A 223
THR A 242
VAL A 269
HIS A 239
 None
 1.09A 5kocB-1y3tA:
undetectable		 5kocB-1y3tA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		4 / 4 HIS A 103
GLU A  69
HIS A  64
HIS A  62
 FE  A 401 (-3.5A)
FE  A 401 (-2.6A)
FE  A 401 (-3.3A)
FE  A 401 (-3.6A)
 1.18A 5n5jA-1y3tA:
undetectable		 5n5jA-1y3tA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		4 / 6 HIS A 275
HIS A 234
LEU A 290
HIS A 239
 FE  A 402 (-3.4A)
FE  A 402 (-3.3A)
None
None
 1.00A 5nelB-1y3tA:
undetectable
5nelC-1y3tA:
undetectable		 5nelB-1y3tA:
22.79
5nelC-1y3tA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		4 / 6 PHE A 266
LEU A  50
ARG A  19
GLY A  21
 None
 1.01A 5o4yA-1y3tA:
undetectable		 5o4yA-1y3tA:
5.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		3 / 3 GLY A 293
LEU A 294
HIS A 239
 None
 0.50A 5u63A-1y3tA:
undetectable		 5u63A-1y3tA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		3 / 3 GLY A 293
LEU A 294
HIS A 239
 None
 0.51A 5u63B-1y3tA:
undetectable		 5u63B-1y3tA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		5 / 12 PHE A 299
HIS A 275
LEU A 332
PHE A 298
LEU A 290
 None
FE  A 402 (-3.4A)
None
None
None
 1.33A 5y2oA-1y3tA:
undetectable		 5y2oA-1y3tA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		3 / 3 HIS A 234
HIS A 275
HIS A 236
 FE  A 402 (-3.3A)
FE  A 402 (-3.4A)
FE  A 402 (-3.4A)
 0.56A 5zrdA-1y3tA:
undetectable		 5zrdA-1y3tA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		4 / 6 PHE A 266
ARG A  19
LEU A  18
ALA A  37
 None
 0.94A 6b89B-1y3tA:
undetectable		 6b89B-1y3tA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 1y3t HYPOTHETICAL PROTEIN
YXAG
(Bacillus
subtilis) 		4 / 7 PHE A 266
ARG A  19
LEU A  18
ALA A  37
 None
 0.97A 6b89A-1y3tA:
undetectable		 6b89A-1y3tA:
14.52