SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y43'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 1y43 ASPERGILLOPEPSIN II
HEAVY CHAIN
(Aspergillus
niger) 		3 / 3 ALA B   9
VAL B  11
TRP B 107
 None
 0.48A 1av2A-1y43B:
undetectable
1av2B-1y43B:
undetectable		 1av2A-1y43B:
6.13
1av2B-1y43B:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 1y43 ASPERGILLOPEPSIN II
HEAVY CHAIN
(Aspergillus
niger) 		3 / 3 TRP B 107
ALA B   9
VAL B  11
 None
 0.57A 1av2C-1y43B:
undetectable
1av2D-1y43B:
undetectable		 1av2C-1y43B:
6.13
1av2D-1y43B:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 1y43 ASPERGILLOPEPSIN II
HEAVY CHAIN
(Aspergillus
niger) 		3 / 3 ALA B   9
VAL B  11
TRP B 107
 None
 0.95A 1gmkA-1y43B:
undetectable
1gmkB-1y43B:
undetectable		 1gmkA-1y43B:
6.13
1gmkB-1y43B:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 1y43 ASPERGILLOPEPSIN II
HEAVY CHAIN
(Aspergillus
niger) 		3 / 3 ALA B   9
VAL B  11
TRP B 107
 None
 0.99A 1gmkC-1y43B:
undetectable
1gmkD-1y43B:
undetectable		 1gmkC-1y43B:
6.13
1gmkD-1y43B:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1y43 ASPERGILLOPEPSIN II
HEAVY CHAIN
(Aspergillus
niger) 		4 / 6 GLY B  26
GLN B  24
ALA B   9
SER B   8
 None
 0.89A 1p6kA-1y43B:
undetectable		 1p6kA-1y43B:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 1y43 ASPERGILLOPEPSIN II
HEAVY CHAIN
(Aspergillus
niger) 		3 / 3 ALA B   9
VAL B  11
TRP B 107
 None
 0.47A 1w5uA-1y43B:
undetectable
1w5uB-1y43B:
undetectable		 1w5uA-1y43B:
6.13
1w5uB-1y43B:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 1y43 ASPERGILLOPEPSIN II
HEAVY CHAIN
(Aspergillus
niger) 		3 / 3 TRP B 107
ALA B   9
VAL B  11
 None
 0.47A 1w5uA-1y43B:
undetectable
1w5uB-1y43B:
undetectable		 1w5uA-1y43B:
6.13
1w5uB-1y43B:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1y43 ASPERGILLOPEPSIN II
HEAVY CHAIN
ASPERGILLOPEPSIN II
LIGHT CHAIN
(Aspergillus
niger) 		5 / 7 ASP B  14
GLY A  14
ILE A  13
VAL A  20
ILE B  13
 None
 1.50A 2aojB-1y43B:
undetectable		 2aojB-1y43B:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 1y43 ASPERGILLOPEPSIN II
HEAVY CHAIN
(Aspergillus
niger) 		3 / 3 ALA B   9
VAL B  11
TRP B 107
 None
 0.59A 2izqA-1y43B:
undetectable
2izqB-1y43B:
undetectable		 2izqA-1y43B:
6.13
2izqB-1y43B:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 1y43 ASPERGILLOPEPSIN II
HEAVY CHAIN
(Aspergillus
niger) 		3 / 3 TRP B 107
ALA B   9
VAL B  11
 None
 0.59A 2izqC-1y43B:
undetectable
2izqD-1y43B:
undetectable		 2izqC-1y43B:
6.13
2izqD-1y43B:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 1y43 ASPERGILLOPEPSIN II
HEAVY CHAIN
(Aspergillus
niger) 		4 / 4 VAL B 119
PHE B 124
VAL B  27
TRP B  41
 None
 1.42A 2y00A-1y43B:
undetectable		 2y00A-1y43B:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 1y43 ASPERGILLOPEPSIN II
HEAVY CHAIN
(Aspergillus
niger) 		3 / 3 TRP B 107
ALA B   9
VAL B  11
 None
 0.76A 3l8lA-1y43B:
undetectable
3l8lB-1y43B:
undetectable		 3l8lA-1y43B:
6.13
3l8lB-1y43B:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 1y43 ASPERGILLOPEPSIN II
HEAVY CHAIN
(Aspergillus
niger) 		3 / 3 TRP B 107
ALA B   9
VAL B  11
 None
 0.48A 3l8lC-1y43B:
undetectable
3l8lD-1y43B:
undetectable		 3l8lC-1y43B:
6.13
3l8lD-1y43B:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1y43 ASPERGILLOPEPSIN II
HEAVY CHAIN
(Aspergillus
niger) 		4 / 4 SER B 117
ASP B 111
ASP B 150
ASP B 154
 None
 1.49A 4uciA-1y43B:
undetectable		 4uciA-1y43B:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1y43 ASPERGILLOPEPSIN II
HEAVY CHAIN
(Aspergillus
niger) 		4 / 4 SER B 117
ASP B 111
ASP B 150
ASP B 154
 None
 1.48A 4uciB-1y43B:
undetectable		 4uciB-1y43B:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 1y43 ASPERGILLOPEPSIN II
HEAVY CHAIN
ASPERGILLOPEPSIN II
LIGHT CHAIN
(Aspergillus
niger) 		5 / 11 ASN A   6
SER A   5
ASP B 111
MET B 149
ILE B 108
 SO4  A 202 (-3.6A)
None
None
SO4  A 202 ( 4.9A)
None
 1.34A 4urnC-1y43A:
undetectable		 4urnC-1y43A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 1y43 ASPERGILLOPEPSIN II
HEAVY CHAIN
(Aspergillus
niger) 		4 / 7 TYR B  50
PHE B  52
ALA B  77
PHE B  92
 None
 1.08A 4uymA-1y43B:
undetectable		 4uymA-1y43B:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1y43 ASPERGILLOPEPSIN II
HEAVY CHAIN
(Aspergillus
niger) 		3 / 3 THR B 135
HIS B  90
LEU B  23
 None
 0.88A 5axdC-1y43B:
undetectable		 5axdC-1y43B:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1y43 ASPERGILLOPEPSIN II
HEAVY CHAIN
(Aspergillus
niger) 		4 / 7 VAL B 168
SER B 167
ALA B 132
GLY B 142
 None
 0.84A 5fpdA-1y43B:
undetectable		 5fpdA-1y43B:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1y43 ASPERGILLOPEPSIN II
HEAVY CHAIN
(Aspergillus
niger) 		4 / 7 VAL B 168
SER B 167
ALA B 132
GLY B 142
 None
 0.83A 5fpdB-1y43B:
undetectable		 5fpdB-1y43B:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1y43 ASPERGILLOPEPSIN II
HEAVY CHAIN
(Aspergillus
niger) 		4 / 7 VAL B 170
VAL B 168
PHE B 129
ILE B 108
 None
 0.90A 5yf9B-1y43B:
undetectable		 5yf9B-1y43B:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 1y43 ASPERGILLOPEPSIN II
HEAVY CHAIN
(Aspergillus
niger) 		4 / 5 ALA B 122
TYR B 172
GLN B 153
ILE B 151
 None
 1.42A 6g9bA-1y43B:
undetectable
6g9bB-1y43B:
undetectable		 6g9bA-1y43B:
19.23
6g9bB-1y43B:
16.77