SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y4j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens) 		3 / 3 TRP A 126
ALA A  87
VAL A 147
 None
 0.88A 1bdwA-1y4jA:
undetectable
1bdwB-1y4jA:
undetectable		 1bdwA-1y4jA:
5.77
1bdwB-1y4jA:
5.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM5_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens) 		4 / 8 TRP A 235
TRP A 169
TRP A 237
GLU A 236
 None
None
None
CA  A1004 (-3.6A)
 1.17A 1om5A-1y4jA:
undetectable
1om5B-1y4jA:
undetectable		 1om5A-1y4jA:
20.94
1om5B-1y4jA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens) 		4 / 8 TRP A 169
TRP A 237
GLU A 236
TRP A 235
 None
None
CA  A1004 (-3.6A)
None
 1.25A 1rs6A-1y4jA:
undetectable
1rs6B-1y4jA:
undetectable		 1rs6A-1y4jA:
20.94
1rs6B-1y4jA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6H_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens) 		4 / 8 TRP A 235
TRP A 169
TRP A 237
GLU A 236
 None
None
None
CA  A1004 (-3.6A)
 1.17A 2g6hA-1y4jA:
undetectable
2g6hB-1y4jA:
undetectable		 2g6hA-1y4jA:
20.43
2g6hB-1y4jA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens) 		4 / 5 TRP A 257
GLY A 203
PHE A  99
PHE A  96
 None
 1.02A 2qr2A-1y4jA:
undetectable
2qr2B-1y4jA:
undetectable		 2qr2A-1y4jA:
20.20
2qr2B-1y4jA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens) 		3 / 3 VAL A 271
ASN A 186
TRP A 187
 None
 1.12A 2y00B-1y4jA:
undetectable		 2y00B-1y4jA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3P_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens) 		4 / 8 TRP A 169
TRP A 237
GLU A 236
TRP A 235
 None
None
CA  A1004 (-3.6A)
None
 1.22A 3b3pA-1y4jA:
undetectable
3b3pB-1y4jA:
undetectable		 3b3pA-1y4jA:
20.79
3b3pB-1y4jA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens) 		3 / 3 THR A 238
SER A 240
PHE A  62
 None
 0.89A 3d4sA-1y4jA:
undetectable		 3d4sA-1y4jA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens) 		4 / 8 TRP A 169
TRP A 237
GLU A 236
TRP A 235
 None
None
CA  A1004 (-3.6A)
None
 1.12A 3e7gC-1y4jA:
undetectable
3e7gD-1y4jA:
undetectable		 3e7gC-1y4jA:
20.44
3e7gD-1y4jA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens) 		4 / 8 TRP A 235
TRP A 169
TRP A 237
GLU A 236
 None
None
None
CA  A1004 (-3.6A)
 1.18A 3nlqA-1y4jA:
undetectable
3nlqB-1y4jA:
undetectable		 3nlqA-1y4jA:
20.47
3nlqB-1y4jA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		 1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens) 		5 / 12 ARG A  55
GLU A 167
ALA A 173
GLU A 166
ARG A 253
 None
 1.43A 3sanA-1y4jA:
undetectable		 3sanA-1y4jA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_1
(NEURAMINIDASE)		 1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens) 		5 / 12 ARG A  55
GLU A 167
ALA A 173
GLU A 166
ARG A 253
 None
 1.43A 3sanB-1y4jA:
undetectable		 3sanB-1y4jA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		 1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens) 		5 / 12 ARG A  55
GLU A 167
ALA A 173
GLU A 166
ARG A 253
 None
 1.44A 3ticB-1y4jA:
undetectable		 3ticB-1y4jA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_1
(NEURAMINIDASE)		 1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens) 		5 / 12 ARG A  55
GLU A 167
ALA A 173
GLU A 166
ARG A 253
 None
 1.43A 4i00A-1y4jA:
undetectable		 4i00A-1y4jA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens) 		4 / 8 ALA A 172
GLU A 236
LEU A 230
LEU A 227
 None
CA  A1004 (-3.6A)
None
None
 0.92A 4jjkA-1y4jA:
undetectable		 4jjkA-1y4jA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		 1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens) 		5 / 12 ARG A  55
GLU A 167
ALA A 173
GLU A 166
ARG A 253
 None
 1.45A 4mwrA-1y4jA:
undetectable		 4mwrA-1y4jA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens) 		4 / 5 THR A 238
THR A 273
HIS A 267
ASN A 285
 None
 1.42A 4pgfB-1y4jA:
undetectable		 4pgfB-1y4jA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens) 		5 / 9 THR A 238
ALA A 239
VAL A  69
GLY A 287
ALA A 152
 None
 1.05A 4qvnK-1y4jA:
undetectable
4qvnL-1y4jA:
undetectable		 4qvnK-1y4jA:
22.60
4qvnL-1y4jA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens) 		5 / 9 THR A 238
ALA A 239
VAL A  69
GLY A 287
ALA A 152
 None
 1.05A 4qvnY-1y4jA:
undetectable
4qvnZ-1y4jA:
undetectable		 4qvnY-1y4jA:
22.60
4qvnZ-1y4jA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCH_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens) 		4 / 8 TRP A 169
TRP A 237
GLU A 236
TRP A 235
 None
None
CA  A1004 (-3.6A)
None
 1.18A 4uchA-1y4jA:
undetectable
4uchB-1y4jA:
undetectable		 4uchA-1y4jA:
21.26
4uchB-1y4jA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3W_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens) 		4 / 7 TRP A 169
TRP A 237
GLU A 236
TRP A 235
 None
None
CA  A1004 (-3.6A)
None
 1.13A 4v3wA-1y4jA:
undetectable
4v3wB-1y4jA:
undetectable		 4v3wA-1y4jA:
20.79
4v3wB-1y4jA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens) 		4 / 7 TRP A 169
TRP A 237
GLU A 236
TRP A 235
 None
None
CA  A1004 (-3.6A)
None
 1.18A 5uo9A-1y4jA:
0.0
5uo9B-1y4jA:
0.0		 5uo9A-1y4jA:
20.69
5uo9B-1y4jA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens) 		4 / 7 TRP A 169
TRP A 237
GLU A 236
TRP A 235
 None
None
CA  A1004 (-3.6A)
None
 1.17A 5uo9C-1y4jA:
0.0
5uo9D-1y4jA:
undetectable		 5uo9C-1y4jA:
20.69
5uo9D-1y4jA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV9_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens) 		4 / 7 TRP A 235
TRP A 169
TRP A 237
GLU A 236
 None
None
None
CA  A1004 (-3.6A)
 1.11A 5vv9A-1y4jA:
0.0
5vv9B-1y4jA:
0.0		 5vv9A-1y4jA:
20.31
5vv9B-1y4jA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVA_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens) 		4 / 7 TRP A 235
TRP A 169
TRP A 237
GLU A 236
 None
None
None
CA  A1004 (-3.6A)
 1.11A 5vvaA-1y4jA:
0.0
5vvaB-1y4jA:
0.0		 5vvaA-1y4jA:
20.31
5vvaB-1y4jA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens) 		4 / 7 TRP A 169
TRP A 237
GLU A 236
TRP A 235
 None
None
CA  A1004 (-3.6A)
None
 1.13A 5vvdA-1y4jA:
0.0
5vvdB-1y4jA:
0.0		 5vvdA-1y4jA:
20.69
5vvdB-1y4jA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens) 		4 / 7 TRP A 235
TRP A 169
TRP A 237
GLU A 236
 None
None
None
CA  A1004 (-3.6A)
 1.11A 6auuA-1y4jA:
undetectable
6auuB-1y4jA:
undetectable		 6auuA-1y4jA:
17.78
6auuB-1y4jA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB503_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens) 		4 / 7 TRP A 169
TRP A 237
GLU A 236
TRP A 235
 None
None
CA  A1004 (-3.6A)
None
 1.14A 6av6A-1y4jA:
0.0
6av6B-1y4jA:
0.0		 6av6A-1y4jA:
13.38
6av6B-1y4jA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens) 		4 / 7 TRP A 169
TRP A 237
GLU A 236
TRP A 235
 None
None
CA  A1004 (-3.6A)
None
 1.11A 6cieA-1y4jA:
0.0
6cieB-1y4jA:
0.0		 6cieA-1y4jA:
13.38
6cieB-1y4jA:
13.38