SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y4u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 4 GLY A  82
LEU A  46
GLY A 173
ARG A 172
 None
 1.47A 1j7kA-1y4uA:
undetectable		 1j7kA-1y4uA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 12 ILE A 120
PHE A 123
ASN A  38
LEU A  94
PHE A 127
 None
 1.05A 1og5B-1y4uA:
undetectable		 1og5B-1y4uA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 12 LEU A 357
LEU A 360
LEU A 363
ALA A 364
LEU A 400
 None
 0.79A 1ya3C-1y4uA:
undetectable		 1ya3C-1y4uA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 5 LEU A 348
LEU A 299
LEU A 324
LEU A 330
 None
 0.84A 1yajD-1y4uA:
undetectable		 1yajD-1y4uA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXD_A_RWFA2001_1
(SERUM ALBUMIN)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 9 TYR A 371
PHE A 320
LEU A 382
ARG A 401
LEU A 400
 None
 0.96A 2bxdA-1y4uA:
0.0		 2bxdA-1y4uA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 12 VAL A  65
ALA A  39
ARG A 236
LEU A 233
ASP A 202
 None
 0.86A 3gcsA-1y4uA:
undetectable		 3gcsA-1y4uA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 6 GLN A 358
LEU A 360
GLU A 361
LEU A 399
 None
 0.78A 3h5gA-1y4uA:
undetectable
3h5gC-1y4uA:
undetectable		 3h5gA-1y4uA:
4.47
3h5gC-1y4uA:
4.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 5 LEU A 399
GLN A 358
LEU A 360
GLU A 361
 None
 1.01A 3h5gA-1y4uA:
undetectable
3h5gB-1y4uA:
undetectable		 3h5gA-1y4uA:
4.47
3h5gB-1y4uA:
4.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 8 ASP A 476
PRO A 479
GLN A 393
GLU A 394
 None
 0.98A 3oyaA-1y4uA:
undetectable		 3oyaA-1y4uA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 12 ARG A 142
GLY A  82
GLY A  84
SER A  40
GLU A  58
 None
 1.26A 3t7sB-1y4uA:
undetectable		 3t7sB-1y4uA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 12 ARG A 142
GLY A  82
GLY A  84
SER A  40
GLU A  58
 None
 1.26A 3t7sD-1y4uA:
undetectable		 3t7sD-1y4uA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 6 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.97A 3wg7P-1y4uA:
undetectable
3wg7W-1y4uA:
undetectable		 3wg7P-1y4uA:
16.99
3wg7W-1y4uA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.98A 3x2qP-1y4uA:
undetectable
3x2qW-1y4uA:
undetectable		 3x2qP-1y4uA:
16.99
3x2qW-1y4uA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 8 TYR A 438
ASP A 408
VAL A 414
LEU A 459
 None
 1.08A 4f8hA-1y4uA:
undetectable
4f8hB-1y4uA:
undetectable		 4f8hA-1y4uA:
20.67
4f8hB-1y4uA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		3 / 3 TYR A 274
ARG A 355
SER A 276
 None
 1.01A 4khpI-1y4uA:
2.1
4khpJ-1y4uA:
undetectable		 4khpI-1y4uA:
12.32
4khpJ-1y4uA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 8 LEU A  94
VAL A 139
ILE A 176
MET A  85
 None
 0.87A 4oj4A-1y4uA:
undetectable		 4oj4A-1y4uA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 6 PHE A  48
ARG A  47
PHE A 305
TYR A 300
 None
 1.48A 4uciA-1y4uA:
undetectable		 4uciA-1y4uA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 PHE A  48
ARG A  47
PHE A 305
TYR A 300
 None
 1.48A 4uciB-1y4uA:
undetectable		 4uciB-1y4uA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		3 / 3 LYS A 212
ILE A 210
ILE A 197
 None
 0.69A 4y0qA-1y4uA:
undetectable		 4y0qA-1y4uA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 10 ALA A  50
GLY A  61
LEU A  63
ALA A  43
ASP A  44
 None
 1.30A 5ajqB-1y4uA:
undetectable		 5ajqB-1y4uA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.94A 5b1aC-1y4uA:
undetectable
5b1aJ-1y4uA:
undetectable		 5b1aC-1y4uA:
16.99
5b1aJ-1y4uA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.91A 5b1aP-1y4uA:
undetectable
5b1aW-1y4uA:
undetectable		 5b1aP-1y4uA:
16.99
5b1aW-1y4uA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.93A 5b1bP-1y4uA:
undetectable
5b1bW-1y4uA:
undetectable		 5b1bP-1y4uA:
16.99
5b1bW-1y4uA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.93A 5b3sC-1y4uA:
undetectable
5b3sJ-1y4uA:
undetectable		 5b3sC-1y4uA:
16.99
5b3sJ-1y4uA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.92A 5b3sP-1y4uA:
undetectable		 5b3sP-1y4uA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 9 LEU A 339
THR A 345
LEU A 348
ILE A 325
LEU A 352
 None
 1.34A 5g48B-1y4uA:
undetectable		 5g48B-1y4uA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 9 THR A 345
LEU A 348
ILE A 325
LEU A 352
MET A 314
 None
 1.42A 5g48B-1y4uA:
undetectable		 5g48B-1y4uA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 10 ALA A  98
ILE A  97
PHE A 131
GLY A 101
VAL A 137
 None
 1.19A 5i6xA-1y4uA:
0.7		 5i6xA-1y4uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 ILE A 455
VAL A 457
TYR A 419
GLN A 481
 None
 1.02A 5kkzC-1y4uA:
undetectable
5kkzE-1y4uA:
undetectable		 5kkzC-1y4uA:
14.37
5kkzE-1y4uA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 ILE A 455
VAL A 457
TYR A 419
GLN A 481
 None
 1.00A 5kkzK-1y4uA:
undetectable
5kkzQ-1y4uA:
0.0		 5kkzK-1y4uA:
21.61
5kkzQ-1y4uA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 ILE A 455
VAL A 457
TYR A 419
GLN A 481
 None
 1.14A 5kkzM-1y4uA:
undetectable
5kkzO-1y4uA:
undetectable		 5kkzM-1y4uA:
14.37
5kkzO-1y4uA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODH_G_ACTG710_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 4 ARG A 181
ILE A 132
TYR A  25
ILE A  21
 None
 1.27A 5odhG-1y4uA:
0.0		 5odhG-1y4uA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 10 LEU A 382
VAL A 381
LEU A 360
VAL A 321
ILE A 280
 None
 1.06A 5v02B-1y4uA:
undetectable
5v02R-1y4uA:
undetectable		 5v02B-1y4uA:
10.59
5v02R-1y4uA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 5 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 1.03A 5x1bP-1y4uA:
undetectable		 5x1bP-1y4uA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.93A 5zcqP-1y4uA:
undetectable
5zcqW-1y4uA:
undetectable		 5zcqP-1y4uA:
16.99
5zcqW-1y4uA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 12 GLU A 273
LEU A 278
SER A 328
LEU A 352
GLN A 358
 None
 1.21A 6ew0F-1y4uA:
undetectable		 6ew0F-1y4uA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 1y4u CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 12 GLU A 273
LEU A 278
SER A 328
LEU A 352
GLN A 358
 None
 1.21A 6ew0G-1y4uA:
undetectable		 6ew0G-1y4uA:
10.20