SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y51'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 1y51 PHOSPHOCARRIER
PROTEIN HPR
(Geobacillus
stearothermophil
us) 		4 / 6 LEU A  81
LEU A  86
SER A  10
SER A  12
 None
 0.96A 1tz8C-1y51A:
undetectable
1tz8D-1y51A:
undetectable		 1tz8C-1y51A:
25.00
1tz8D-1y51A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1y51 PHOSPHOCARRIER
PROTEIN HPR
(Geobacillus
stearothermophil
us) 		5 / 8 ALA A  73
LEU A  77
LEU A  22
VAL A  50
ILE A  47
 None
 1.34A 2uxpA-1y51A:
undetectable		 2uxpA-1y51A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1y51 PHOSPHOCARRIER
PROTEIN HPR
(Geobacillus
stearothermophil
us) 		4 / 8 LEU A  44
LEU A  35
ALA A  65
PHE A   6
 None
 0.90A 2vcvF-1y51A:
undetectable		 2vcvF-1y51A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 1y51 PHOSPHOCARRIER
PROTEIN HPR
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A  14
LEU A  35
VAL A   8
GLU A   3
ILE A  33
 None
 1.19A 2vn0A-1y51A:
undetectable		 2vn0A-1y51A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 1y51 PHOSPHOCARRIER
PROTEIN HPR
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A  35
LEU A  53
PRO A  56
ILE A  55
 None
 0.81A 3s56B-1y51A:
undetectable		 3s56B-1y51A:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1y51 PHOSPHOCARRIER
PROTEIN HPR
(Geobacillus
stearothermophil
us) 		4 / 8 LEU A  81
LEU A  86
VAL A   8
ILE A  55
 None
 0.96A 4oj4A-1y51A:
undetectable		 4oj4A-1y51A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1y51 PHOSPHOCARRIER
PROTEIN HPR
(Geobacillus
stearothermophil
us) 		3 / 3 LYS A  40
LEU A  44
ILE A  61
 None
 0.67A 5kc0A-1y51A:
undetectable		 5kc0A-1y51A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1y51 PHOSPHOCARRIER
PROTEIN HPR
(Geobacillus
stearothermophil
us) 		3 / 3 LYS A  40
LEU A  44
ILE A  61
 None
 0.66A 5kc4A-1y51A:
undetectable		 5kc4A-1y51A:
27.81