SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y56'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_1
(HIV-1 PROTEASE)		 1y56 HYPOTHETICAL PROTEIN
PH1363
(Pyrococcus
horikoshii) 		5 / 12 ALA A 476
ILE A 316
GLY A 321
GLY A 320
ILE A 480
 None
 0.83A 1hxbA-1y56A:
undetectable		 1hxbA-1y56A:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_2
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION
CHIMERA OF IG
GAMMA-1 CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		4 / 5 TYR B 247
GLU B  96
TYR B  92
ASP B  93
 None
 1.23A 1i7zB-1y56B:
0.0		 1i7zB-1y56B:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 1y56 HYPOTHETICAL PROTEIN
PH1363
(Pyrococcus
horikoshii) 		5 / 11 ALA A 476
ILE A 316
GLY A 321
GLY A 320
ILE A 480
 None
 0.85A 1sduA-1y56A:
undetectable		 1sduA-1y56A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 1y56 HYPOTHETICAL PROTEIN
PH1363
(Pyrococcus
horikoshii) 		5 / 10 ALA A 476
ILE A 316
GLY A 321
GLY A 320
ILE A 480
 None
 0.81A 1sdvA-1y56A:
undetectable		 1sdvA-1y56A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		5 / 12 ILE B  11
GLY B  12
GLY B  14
ILE B  20
GLU B 171
 None
FAD  B 800 (-3.3A)
FAD  B 800 (-3.3A)
None
FAD  B 800 (-4.7A)
 0.73A 1sg9B-1y56B:
2.4		 1sg9B-1y56B:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		5 / 11 ILE B  34
THR B  32
LYS B 165
LEU B 167
THR B 187
 None
 1.11A 1tw4A-1y56B:
undetectable		 1tw4A-1y56B:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		5 / 12 ILE B  11
GLY B  12
GLY B  14
ILE B  20
GLU B 171
 None
FAD  B 800 (-3.3A)
FAD  B 800 (-3.3A)
None
FAD  B 800 (-4.7A)
 0.77A 1vq1B-1y56B:
2.5		 1vq1B-1y56B:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		4 / 4 LEU B  91
PRO B 113
ILE B 117
LEU B 116
 None
 1.10A 1ya4C-1y56B:
0.7		 1ya4C-1y56B:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		5 / 7 LEU B  90
GLY B 265
ILE B 264
VAL B 242
ILE B 243
 None
 1.44A 2aojB-1y56B:
undetectable		 2aojB-1y56B:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 1y56 HYPOTHETICAL PROTEIN
PH1363
(Pyrococcus
horikoshii) 		5 / 12 ALA A 476
ILE A 316
GLY A 321
GLY A 320
ILE A 480
 None
 0.82A 2avsA-1y56A:
undetectable		 2avsA-1y56A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_1
(POL POLYPROTEIN)		 1y56 HYPOTHETICAL PROTEIN
PH1363
(Pyrococcus
horikoshii) 		5 / 12 ALA A 476
ILE A 316
GLY A 321
GLY A 320
ILE A 480
 None
 0.81A 2avvA-1y56A:
undetectable		 2avvA-1y56A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_1
(POL POLYPROTEIN)		 1y56 HYPOTHETICAL PROTEIN
PH1363
(Pyrococcus
horikoshii) 		5 / 12 ALA A 476
ILE A 316
GLY A 321
GLY A 320
ILE A 480
 None
 0.81A 2avvD-1y56A:
undetectable		 2avvD-1y56A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		3 / 3 LYS B 145
GLY B 259
PRO B 232
 None
 1.01A 2hreB-1y56B:
undetectable		 2hreB-1y56B:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1y56 HYPOTHETICAL PROTEIN
PH1363
(Pyrococcus
horikoshii) 		5 / 12 TYR A 369
ALA A 121
ALA A 368
GLY A 348
GLY A 118
 None
None
None
ATP  A 801 (-3.1A)
None
 1.03A 2igtA-1y56A:
2.8		 2igtA-1y56A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1y56 HYPOTHETICAL PROTEIN
PH1363
(Pyrococcus
horikoshii) 		5 / 12 TYR A 369
ALA A 121
ALA A 368
GLY A 348
GLY A 118
 None
None
None
ATP  A 801 (-3.1A)
None
 1.03A 2igtB-1y56A:
2.9		 2igtB-1y56A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		5 / 10 VAL B 348
ALA B 349
THR B 353
VAL B  31
ILE B 196
 None
 1.07A 2nnjA-1y56B:
undetectable		 2nnjA-1y56B:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 1y56 HYPOTHETICAL PROTEIN
PH1363
(Pyrococcus
horikoshii) 		5 / 12 ALA A 476
ILE A 316
GLY A 321
GLY A 320
ILE A 480
 None
 0.82A 2o4kA-1y56A:
0.0		 2o4kA-1y56A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1y56 HYPOTHETICAL PROTEIN
PH1363
(Pyrococcus
horikoshii) 		5 / 12 GLY A 214
GLY A 363
GLY A 118
GLY A 115
LEU A 125
 ATP  A 801 (-3.5A)
None
None
ATP  A 801 (-3.2A)
None
 0.86A 2oxtB-1y56A:
undetectable		 2oxtB-1y56A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		5 / 11 LEU B  90
VAL B 242
ILE B 131
VAL B 126
ILE B 238
 None
 1.06A 2uxoB-1y56B:
0.0		 2uxoB-1y56B:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		5 / 10 THR B 187
ILE B 192
PHE B 175
THR B 170
ILE B  11
 None
 0.97A 2y7wB-1y56B:
undetectable		 2y7wB-1y56B:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 1y56 HYPOTHETICAL PROTEIN
PH1363
(Pyrococcus
horikoshii) 		4 / 5 VAL A 422
GLN A 411
PHE A 454
ARG A  50
 None
 1.45A 3bjwE-1y56A:
undetectable		 3bjwE-1y56A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 1y56 HYPOTHETICAL PROTEIN
PH1363
(Pyrococcus
horikoshii) 		6 / 12 GLY A 320
ASP A 186
GLY A 183
ILE A 480
VAL A 210
ILE A 344
 None
 1.47A 3bvbB-1y56A:
undetectable		 3bvbB-1y56A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1y56 HYPOTHETICAL PROTEIN
PH1363
(Pyrococcus
horikoshii) 		5 / 12 GLY A 113
GLY A 114
GLU A 135
ARG A 137
ALA A 181
 ATP  A 801 (-3.2A)
ATP  A 801 ( 4.9A)
ATP  A 801 (-2.4A)
ATP  A 801 (-4.1A)
ATP  A 801 (-3.7A)
 1.07A 3ckkA-1y56A:
3.6		 3ckkA-1y56A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		5 / 12 ALA B 137
ILE B 125
ILE B 238
LEU B 252
ILE B 291
 None
 1.04A 3clbC-1y56B:
undetectable		 3clbC-1y56B:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)		 1y56 HYPOTHETICAL PROTEIN
PH1363
(Pyrococcus
horikoshii) 		5 / 12 ALA A 476
ILE A 316
GLY A 321
GLY A 320
ILE A 480
 None
 0.82A 3cyxB-1y56A:
undetectable		 3cyxB-1y56A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		5 / 12 ILE B 318
ALA B 317
ASN B 199
PHE B 333
ILE B  20
 None
None
None
FAD  B 800 ( 4.9A)
None
 1.07A 3e00A-1y56B:
undetectable		 3e00A-1y56B:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		5 / 11 GLY B  13
GLY B  40
ALA B 156
THR B 153
ALA B  21
 None
 1.01A 3g88A-1y56B:
undetectable		 3g88A-1y56B:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		5 / 11 GLY B  13
GLY B  40
ALA B 156
THR B 153
ALA B  21
 None
 1.02A 3g88B-1y56B:
undetectable		 3g88B-1y56B:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		5 / 12 GLY B  13
GLY B  40
ALA B 156
THR B 153
ALA B  21
 None
 0.99A 3g89A-1y56B:
undetectable		 3g89A-1y56B:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		5 / 11 GLY B  13
GLY B  40
ALA B 156
THR B 153
ALA B  21
 None
 1.00A 3g89B-1y56B:
undetectable		 3g89B-1y56B:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		5 / 12 GLY B  13
GLY B  40
ALA B 156
THR B 153
ALA B  21
 None
 1.01A 3g8bA-1y56B:
undetectable		 3g8bA-1y56B:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		5 / 12 GLY B  13
GLY B  40
ALA B 156
THR B 153
ALA B  21
 None
 1.04A 3g8bB-1y56B:
undetectable		 3g8bB-1y56B:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 1y56 HYPOTHETICAL PROTEIN
PH1363
SARCOSINE OXIDASE
(Pyrococcus
horikoshii;
Pyrococcus
horikoshii) 		5 / 12 LEU A 182
VAL A 196
ILE A 202
PRO A 194
TYR B 278
 None
 1.35A 3hgiA-1y56A:
undetectable		 3hgiA-1y56A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 1y56 HYPOTHETICAL PROTEIN
PH1363
(Pyrococcus
horikoshii) 		5 / 12 GLY A 113
GLY A 363
GLY A 120
LEU A 125
ALA A 347
 ATP  A 801 (-3.2A)
None
None
None
None
 1.09A 3kkzB-1y56A:
2.8		 3kkzB-1y56A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1y56 HYPOTHETICAL PROTEIN
PH1363
(Pyrococcus
horikoshii) 		4 / 4 GLY A 148
GLU A 264
ASP A 143
ASP A 157
 None
 1.30A 3mb5A-1y56A:
3.7		 3mb5A-1y56A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		4 / 5 GLY B 144
ASP B 143
ARG B  52
MET B 347
 None
 1.25A 3qx3B-1y56B:
undetectable		 3qx3B-1y56B:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		5 / 8 ALA B 151
ASP B 147
GLY B  40
ILE B  39
THR B  19
 None
FMN  A 802 ( 4.8A)
None
None
None
 1.28A 3so9A-1y56B:
undetectable		 3so9A-1y56B:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 1y56 HYPOTHETICAL PROTEIN
PH1363
(Pyrococcus
horikoshii) 		3 / 3 TYR A  41
MET A   1
LEU A   6
 None
 0.77A 3vw1D-1y56A:
undetectable		 3vw1D-1y56A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		5 / 12 LEU B 351
PHE B 333
ILE B 218
VAL B 361
VAL B  63
 None
FAD  B 800 ( 4.9A)
None
None
None
 0.96A 3w68D-1y56B:
undetectable		 3w68D-1y56B:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 1y56 HYPOTHETICAL PROTEIN
PH1363
(Pyrococcus
horikoshii) 		4 / 6 GLY A 367
ALA A 368
TYR A 369
GLU A 384
 None
 0.99A 4ae1A-1y56A:
undetectable		 4ae1A-1y56A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		5 / 12 ALA B 250
SER B 244
VAL B 242
THR B 230
ILE B 292
 None
 1.16A 4c49A-1y56B:
undetectable		 4c49A-1y56B:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		5 / 12 GLY B 345
ALA B 343
VAL B  63
ALA B 330
VAL B 348
 None
 1.38A 4df3B-1y56B:
2.6		 4df3B-1y56B:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		3 / 3 LYS B 145
THR B  49
ILE B 229
 None
None
FMN  A 802 ( 4.1A)
 0.90A 4e0fB-1y56B:
undetectable		 4e0fB-1y56B:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1y56 HYPOTHETICAL PROTEIN
PH1363
SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		4 / 8 ARG A 490
ALA B 250
SER B 244
TYR B 287
 None
 1.05A 4lv9A-1y56A:
undetectable
4lv9B-1y56A:
undetectable		 4lv9A-1y56A:
23.47
4lv9B-1y56A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1y56 HYPOTHETICAL PROTEIN
PH1363
(Pyrococcus
horikoshii) 		3 / 3 LEU A 201
ILE A 102
ARG A 104
 None
 0.65A 4mk4B-1y56A:
undetectable		 4mk4B-1y56A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 1y56 HYPOTHETICAL PROTEIN
PH1363
(Pyrococcus
horikoshii) 		5 / 12 GLY A 113
GLY A 114
ALA A 122
LEU A 169
GLY A 348
 ATP  A 801 (-3.2A)
ATP  A 801 ( 4.9A)
None
None
ATP  A 801 (-3.1A)
 0.88A 4n09C-1y56A:
3.1		 4n09C-1y56A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		4 / 5 ILE B 192
VAL B   9
ILE B  11
VAL B 185
 None
 0.76A 4xdtA-1y56B:
undetectable		 4xdtA-1y56B:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 1y56 HYPOTHETICAL PROTEIN
PH1363
(Pyrococcus
horikoshii) 		4 / 8 ALA A 347
GLY A 363
ALA A 121
GLY A 118
 None
 0.62A 4zjzA-1y56A:
undetectable		 4zjzA-1y56A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		4 / 7 ILE B 318
PHE B 333
VAL B 348
ILE B  20
 None
FAD  B 800 ( 4.9A)
None
None
 0.85A 4zzbC-1y56B:
undetectable
4zzbD-1y56B:
undetectable		 4zzbC-1y56B:
20.15
4zzbD-1y56B:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1y56 HYPOTHETICAL PROTEIN
PH1363
SARCOSINE OXIDASE
(Pyrococcus
horikoshii;
Pyrococcus
horikoshii) 		4 / 7 ARG A 490
PHE B 280
ILE B 264
TYR B 287
 None
 1.40A 5a06B-1y56A:
undetectable		 5a06B-1y56A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 1y56 HYPOTHETICAL PROTEIN
PH1363
SARCOSINE OXIDASE
(Pyrococcus
horikoshii;
Pyrococcus
horikoshii) 		3 / 3 ASP A 472
ARG B 302
ARG B  46
 None
FMN  A 802 (-4.0A)
FMN  A 802 ( 2.8A)
 0.98A 5eajB-1y56A:
undetectable		 5eajB-1y56A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 1y56 HYPOTHETICAL PROTEIN
PH1363
(Pyrococcus
horikoshii) 		5 / 12 VAL A 210
PRO A 116
ALA A 117
LEU A 334
ILE A 216
 None
ATP  A 801 (-3.3A)
ATP  A 801 (-3.4A)
None
None
 1.23A 5hv1A-1y56A:
undetectable		 5hv1A-1y56A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		5 / 9 ILE B  20
MET B  64
VAL B  63
TYR B 328
LEU B  24
 None
 1.22A 5iepA-1y56B:
undetectable		 5iepA-1y56B:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		5 / 12 TYR B 308
SER B 244
PHE B  89
TYR B  87
MET B 241
 FAD  B 800 ( 4.9A)
None
None
None
None
 1.40A 5igwA-1y56B:
0.0		 5igwA-1y56B:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		4 / 7 GLY B 345
VAL B 198
ILE B   8
VAL B  10
 None
 0.78A 5ik1A-1y56B:
undetectable		 5ik1A-1y56B:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1y56 HYPOTHETICAL PROTEIN
PH1363
(Pyrococcus
horikoshii) 		4 / 6 ARG A 232
ARG A 233
ALA A 236
PHE A 305
 None
 1.34A 5odqA-1y56A:
21.1		 5odqA-1y56A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		4 / 6 VAL B  33
LYS B 165
ILE B  39
LYS B 160
 None
 1.45A 5q1sA-1y56B:
undetectable		 5q1sA-1y56B:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 1y56 HYPOTHETICAL PROTEIN
PH1363
(Pyrococcus
horikoshii) 		4 / 8 LEU A 165
LEU A 123
PRO A 116
MET A 144
 None
None
ATP  A 801 (-3.3A)
None
 1.01A 5u4sB-1y56A:
3.2		 5u4sB-1y56A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		4 / 8 ILE B 318
ASN B 199
PRO B 312
THR B 311
 None
 1.12A 5x23A-1y56B:
undetectable		 5x23A-1y56B:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 1y56 HYPOTHETICAL PROTEIN
PH1363
(Pyrococcus
horikoshii) 		4 / 6 LEU A 129
LYS A 364
GLU A 124
LEU A 371
 None
 1.18A 5xooA-1y56A:
undetectable		 5xooA-1y56A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJS_A_SALA603_0
(VICILIN-LIKE
ANTIMICROBIAL
PEPTIDES 2-2)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		5 / 11 GLY B  13
ASN B 199
VAL B  16
PHE B 333
GLY B  17
 None
None
FAD  B 800 (-3.8A)
FAD  B 800 ( 4.9A)
None
 1.31A 5yjsA-1y56B:
0.0		 5yjsA-1y56B:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1y56 HYPOTHETICAL PROTEIN
PH1363
(Pyrococcus
horikoshii) 		5 / 10 MET A   1
ILE A 270
ALA A 246
LEU A   4
ALA A  37
 None
 1.25A 5zjiB-1y56A:
undetectable		 5zjiB-1y56A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 1y56 HYPOTHETICAL PROTEIN
PH1363
(Pyrococcus
horikoshii) 		4 / 8 GLU A 362
THR A 213
ILE A 316
PRO A 332
 None
ATP  A 801 (-4.3A)
None
None
 1.11A 6a4iA-1y56A:
0.0		 6a4iA-1y56A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		3 / 3 TYR B  87
ALA B 137
LEU B  90
 None
 0.68A 6ag0C-1y56B:
undetectable		 6ag0C-1y56B:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		5 / 10 GLY B  12
GLY B  14
GLU B  35
THR B 201
ILE B 208
 FAD  B 800 (-3.3A)
FAD  B 800 (-3.3A)
FAD  B 800 (-2.7A)
FAD  B 800 (-4.2A)
None
 0.57A 6exiA-1y56B:
2.5		 6exiA-1y56B:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		5 / 10 GLY B  12
GLY B  14
GLU B  35
THR B 201
ILE B 208
 FAD  B 800 (-3.3A)
FAD  B 800 (-3.3A)
FAD  B 800 (-2.7A)
FAD  B 800 (-4.2A)
None
 0.54A 6exiB-1y56B:
undetectable		 6exiB-1y56B:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		5 / 12 GLY B  12
GLY B  14
GLU B  35
THR B 201
ILE B 208
 FAD  B 800 (-3.3A)
FAD  B 800 (-3.3A)
FAD  B 800 (-2.7A)
FAD  B 800 (-4.2A)
None
 0.57A 6exiC-1y56B:
undetectable
6exiD-1y56B:
undetectable		 6exiC-1y56B:
12.20
6exiD-1y56B:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1y56 SARCOSINE OXIDASE
(Pyrococcus
horikoshii) 		5 / 12 GLY B  12
GLY B  14
GLU B  35
THR B 201
ILE B 208
 FAD  B 800 (-3.3A)
FAD  B 800 (-3.3A)
FAD  B 800 (-2.7A)
FAD  B 800 (-4.2A)
None
 0.55A 6exiC-1y56B:
undetectable
6exiD-1y56B:
undetectable		 6exiC-1y56B:
12.20
6exiD-1y56B:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_B_PQNB2002_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1y56 HYPOTHETICAL PROTEIN
PH1363
(Pyrococcus
horikoshii) 		5 / 9 MET A   1
ILE A 270
ALA A 246
LEU A   4
ALA A  37
 None
 1.25A 6hqbB-1y56A:
undetectable		 6hqbB-1y56A:
9.92