SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y60'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 1y60 FORMALDEHYDE-ACTIVAT
ING ENZYME FAE
(Methylobacterium
extorquens) 		5 / 11 GLY A  10
ALA A 145
ILE A   4
GLY A  28
ILE A 142
 None
 0.96A 1n49B-1y60A:
undetectable		 1n49B-1y60A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 1y60 FORMALDEHYDE-ACTIVAT
ING ENZYME FAE
(Methylobacterium
extorquens) 		5 / 11 GLY A  10
ALA A 145
ILE A   4
GLY A  28
ILE A 142
 None
 0.94A 1n49C-1y60A:
undetectable		 1n49C-1y60A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 1y60 FORMALDEHYDE-ACTIVAT
ING ENZYME FAE
(Methylobacterium
extorquens) 		6 / 12 GLY A  10
ALA A 145
GLY A  28
PRO A  64
VAL A  95
ILE A 142
 None
 1.28A 2ienA-1y60A:
undetectable		 2ienA-1y60A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 1y60 FORMALDEHYDE-ACTIVAT
ING ENZYME FAE
(Methylobacterium
extorquens) 		4 / 5 ILE A  26
LEU A  42
GLY A  41
PHE A  38
 None
 0.96A 5kmdC-1y60A:
undetectable
5kmdD-1y60A:
undetectable		 5kmdC-1y60A:
21.14
5kmdD-1y60A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 1y60 FORMALDEHYDE-ACTIVAT
ING ENZYME FAE
(Methylobacterium
extorquens) 		4 / 7 PRO A  64
ILE A 142
ILE A  27
THR A  66
 None
 0.81A 5murB-1y60A:
undetectable		 5murB-1y60A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1y60 FORMALDEHYDE-ACTIVAT
ING ENZYME FAE
(Methylobacterium
extorquens) 		3 / 3 LEU A  53
ALA A  54
LEU A  42
 None
 0.55A 5uunB-1y60A:
undetectable		 5uunB-1y60A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 1y60 FORMALDEHYDE-ACTIVAT
ING ENZYME FAE
(Methylobacterium
extorquens) 		3 / 3 VAL A  99
ALA A 109
GLN A  96
 None
 0.61A 6gb9A-1y60A:
undetectable		 6gb9A-1y60A:
16.91