SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y63'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 1y63 LMAJ004144AAA
PROTEIN
(Leishmania
major) 		4 / 4 SER A  92
VAL A 106
PHE A  96
VAL A  42
 None
 1.36A 1o86A-1y63A:
undetectable		 1o86A-1y63A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1y63 LMAJ004144AAA
PROTEIN
(Leishmania
major) 		5 / 12 ILE A  15
LEU A  14
HIS A  86
ALA A  27
LEU A  72
 None
None
MN  A 354 (-3.5A)
None
None
 1.19A 2a58A-1y63A:
4.2
2a58B-1y63A:
4.2		 2a58A-1y63A:
20.41
2a58B-1y63A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1y63 LMAJ004144AAA
PROTEIN
(Leishmania
major) 		5 / 12 ILE A  15
LEU A  14
HIS A  86
ALA A  27
LEU A  72
 None
None
MN  A 354 (-3.5A)
None
None
 1.17A 2a58B-1y63A:
4.2
2a58C-1y63A:
4.3		 2a58B-1y63A:
20.41
2a58C-1y63A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1y63 LMAJ004144AAA
PROTEIN
(Leishmania
major) 		5 / 12 ILE A  15
LEU A  14
HIS A  86
ALA A  27
LEU A  72
 None
None
MN  A 354 (-3.5A)
None
None
 1.18A 2a58D-1y63A:
4.2
2a58E-1y63A:
4.2		 2a58D-1y63A:
20.41
2a58E-1y63A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 1y63 LMAJ004144AAA
PROTEIN
(Leishmania
major) 		4 / 8 MET A 103
LEU A  14
LEU A 107
VAL A  87
 None
 0.99A 2bdmA-1y63A:
undetectable		 2bdmA-1y63A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1y63 LMAJ004144AAA
PROTEIN
(Leishmania
major) 		3 / 3 ILE A  13
PHE A 101
HIS A  39
 None
None
MN  A 311 (-3.3A)
 0.68A 3h0aA-1y63A:
undetectable		 3h0aA-1y63A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1y63 LMAJ004144AAA
PROTEIN
(Leishmania
major) 		4 / 7 GLU A  69
ILE A  64
TYR A  90
VAL A 104
 None
None
MN  A 356 ( 4.7A)
None
 0.95A 4a97H-1y63A:
undetectable		 4a97H-1y63A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1y63 LMAJ004144AAA
PROTEIN
(Leishmania
major) 		4 / 6 GLU A  69
ILE A  64
TYR A  90
VAL A 104
 None
None
MN  A 356 ( 4.7A)
None
 1.00A 4a97I-1y63A:
undetectable		 4a97I-1y63A:
21.20