SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y6j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLY A  14
ALA A  22
THR A  81
ILE A  12
 None
 0.77A 1c9sI-1y6jA:
undetectable
1c9sJ-1y6jA:
undetectable		 1c9sI-1y6jA:
15.48
1c9sJ-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLY A  14
ALA A  22
THR A  81
ILE A  12
 None
 0.77A 1c9sU-1y6jA:
undetectable
1c9sV-1y6jA:
undetectable		 1c9sU-1y6jA:
15.48
1c9sV-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLY A  14
ALA A  22
THR A  81
ILE A  12
 None
 0.79A 1gtnA-1y6jA:
undetectable
1gtnB-1y6jA:
undetectable		 1gtnA-1y6jA:
15.48
1gtnB-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 ALA A 239
GLY A  14
ALA A  22
THR A  81
ILE A  12
 None
 1.10A 1gtnB-1y6jA:
undetectable
1gtnC-1y6jA:
undetectable		 1gtnB-1y6jA:
15.48
1gtnC-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLY A  14
ALA A  22
THR A  81
ILE A  12
 None
 0.75A 1gtnE-1y6jA:
undetectable
1gtnF-1y6jA:
undetectable		 1gtnE-1y6jA:
15.48
1gtnF-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 ALA A 239
GLY A  14
ALA A  22
THR A  81
ILE A  12
 None
 1.13A 1gtnH-1y6jA:
undetectable
1gtnI-1y6jA:
undetectable		 1gtnH-1y6jA:
15.48
1gtnI-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 11 GLY A  14
ALA A  22
THR A  81
ILE A  12
ALA A 239
 None
 1.15A 1gtnM-1y6jA:
undetectable
1gtnN-1y6jA:
undetectable		 1gtnM-1y6jA:
15.48
1gtnN-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 GLY A  14
ALA A  22
THR A  81
ILE A  12
ALA A 239
 None
 1.12A 1gtnU-1y6jA:
undetectable
1gtnV-1y6jA:
undetectable		 1gtnU-1y6jA:
15.48
1gtnV-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 GLY A 148
HIS A 179
VAL A 121
ALA A 273
ILE A 274
 None
 1.07A 1likA-1y6jA:
2.7		 1likA-1y6jA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ILE A 175
ALA A 217
ILE A 197
PRO A 185
 None
 0.89A 1oniB-1y6jA:
1.0
1oniC-1y6jA:
undetectable		 1oniB-1y6jA:
19.75
1oniC-1y6jA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 LEU A  35
ALA A  49
ILE A  52
GLY A  19
 None
 0.82A 1sv9A-1y6jA:
undetectable		 1sv9A-1y6jA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLY A  14
ALA A  22
THR A  81
ILE A  12
 None
 0.79A 1utdB-1y6jA:
undetectable
1utdC-1y6jA:
undetectable		 1utdB-1y6jA:
15.48
1utdC-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLY A  14
ALA A  22
THR A  81
ILE A  12
 None
 0.77A 1utdF-1y6jA:
undetectable
1utdG-1y6jA:
undetectable		 1utdF-1y6jA:
15.48
1utdG-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLY A  14
ALA A  22
THR A  81
ILE A  12
 None
 0.75A 1utdI-1y6jA:
undetectable
1utdJ-1y6jA:
undetectable		 1utdI-1y6jA:
15.48
1utdJ-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLY A  14
ALA A  22
THR A  81
ILE A  12
 None
 0.75A 1utdJ-1y6jA:
undetectable
1utdK-1y6jA:
undetectable		 1utdJ-1y6jA:
15.48
1utdK-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_T_TRPT81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 GLY A  14
ALA A  22
THR A  81
ILE A  12
ALA A 239
 None
 1.15A 1utdT-1y6jA:
undetectable
1utdU-1y6jA:
undetectable		 1utdT-1y6jA:
15.48
1utdU-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 THR A 261
GLY A 148
THR A 149
VAL A 288
 None
 0.69A 2a1hA-1y6jA:
undetectable
2a1hB-1y6jA:
undetectable		 2a1hA-1y6jA:
20.21
2a1hB-1y6jA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 VAL A 288
THR A 261
GLY A 148
THR A 149
 None
 0.67A 2a1hA-1y6jA:
undetectable
2a1hB-1y6jA:
undetectable		 2a1hA-1y6jA:
20.21
2a1hB-1y6jA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A 227
GLY A 224
LEU A 151
GLY A 237
ALA A 223
 None
 0.95A 2fk8A-1y6jA:
4.2		 2fk8A-1y6jA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		4 / 6 SER A 182
ASP A 181
SER A 304
VAL A 308
 None
 1.13A 2hdnI-1y6jA:
undetectable
2hdnJ-1y6jA:
2.5
2hdnL-1y6jA:
2.5		 2hdnI-1y6jA:
10.07
2hdnJ-1y6jA:
23.36
2hdnL-1y6jA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 GLN A 307
LYS A 309
VAL A 311
 None
 0.56A 2jfaB-1y6jA:
undetectable		 2jfaB-1y6jA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 11 ALA A 239
MET A  26
GLY A  19
ILE A  12
VAL A  77
 None
 1.31A 2uxpB-1y6jA:
undetectable		 2uxpB-1y6jA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 SER A 147
GLY A 148
GLY A 146
VAL A 315
ASP A 127
 None
 1.00A 3gczA-1y6jA:
4.4		 3gczA-1y6jA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ASN A 198
GLY A 173
SER A 188
ILE A 192
LEU A 160
 None
 1.17A 3iv6A-1y6jA:
3.5		 3iv6A-1y6jA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 9 VAL A 122
ILE A 238
ALA A  23
THR A  25
VAL A 246
 None
 1.17A 3me6D-1y6jA:
undetectable		 3me6D-1y6jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 VAL A 106
TYR A 113
VAL A  80
ILE A  38
 None
 1.02A 4aftD-1y6jA:
undetectable
4aftE-1y6jA:
undetectable		 4aftD-1y6jA:
19.31
4aftE-1y6jA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A 146
SER A 123
ILE A 245
VAL A  77
VAL A 246
 None
 0.92A 5dpdA-1y6jA:
4.5		 5dpdA-1y6jA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A 146
SER A 123
ILE A 245
VAL A  77
VAL A 246
 None
 0.94A 5dpdB-1y6jA:
4.6		 5dpdB-1y6jA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 ALA A 239
GLY A  14
ALA A  22
THR A  81
ILE A  12
 None
 1.11A 5eeuF-1y6jA:
undetectable
5eeuG-1y6jA:
undetectable		 5eeuF-1y6jA:
15.48
5eeuG-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ALA A 239
GLY A  14
ALA A  22
THR A  81
ILE A  12
 None
 1.08A 5eeuI-1y6jA:
0.0
5eeuJ-1y6jA:
0.0		 5eeuI-1y6jA:
15.48
5eeuJ-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 GLY A  14
ALA A  22
THR A  81
ILE A  12
ALA A 239
 None
 1.15A 5eeuO-1y6jA:
undetectable
5eeuP-1y6jA:
undetectable		 5eeuO-1y6jA:
15.48
5eeuP-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 GLY A  14
ALA A  22
THR A  81
ILE A  12
ALA A 239
 None
 1.14A 5eeuQ-1y6jA:
undetectable
5eeuR-1y6jA:
undetectable		 5eeuQ-1y6jA:
15.48
5eeuR-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 ALA A 239
GLY A  14
ALA A  22
THR A  81
ILE A  12
 None
 1.11A 5eevF-1y6jA:
undetectable
5eevG-1y6jA:
undetectable		 5eevF-1y6jA:
15.48
5eevG-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ALA A 239
GLY A  14
ALA A  22
THR A  81
ILE A  12
 None
 1.09A 5eevI-1y6jA:
undetectable
5eevJ-1y6jA:
0.0		 5eevI-1y6jA:
15.48
5eevJ-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 GLY A  14
ALA A  22
THR A  81
ILE A  12
ALA A 239
 None
 1.15A 5eevO-1y6jA:
undetectable
5eevP-1y6jA:
undetectable		 5eevO-1y6jA:
15.48
5eevP-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 GLY A  14
ALA A  22
THR A  81
ILE A  12
ALA A 239
 None
 1.14A 5eevQ-1y6jA:
undetectable
5eevR-1y6jA:
undetectable		 5eevQ-1y6jA:
15.48
5eevR-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 ALA A 239
GLY A  14
ALA A  22
THR A  81
ILE A  12
 None
 1.11A 5eewF-1y6jA:
undetectable
5eewG-1y6jA:
undetectable		 5eewF-1y6jA:
15.48
5eewG-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ALA A 239
GLY A  14
ALA A  22
THR A  81
ILE A  12
 None
 1.09A 5eewI-1y6jA:
undetectable
5eewJ-1y6jA:
undetectable		 5eewI-1y6jA:
15.48
5eewJ-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 GLY A  14
ALA A  22
THR A  81
ILE A  12
ALA A 239
 None
 1.15A 5eewO-1y6jA:
undetectable
5eewP-1y6jA:
undetectable		 5eewO-1y6jA:
15.48
5eewP-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 GLY A  14
ALA A  22
THR A  81
ILE A  12
ALA A 239
 None
 1.14A 5eewQ-1y6jA:
undetectable
5eewR-1y6jA:
undetectable		 5eewQ-1y6jA:
15.48
5eewR-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 ALA A 239
GLY A  14
ALA A  22
THR A  81
ILE A  12
 None
 1.11A 5eexF-1y6jA:
undetectable
5eexG-1y6jA:
undetectable		 5eexF-1y6jA:
15.48
5eexG-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 GLY A  14
ALA A  22
THR A  81
ILE A  12
ALA A 239
 None
 1.15A 5eexO-1y6jA:
undetectable
5eexP-1y6jA:
undetectable		 5eexO-1y6jA:
15.48
5eexP-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 ALA A 239
GLY A  14
ALA A  22
THR A  81
ILE A  12
 None
 1.10A 5eeyF-1y6jA:
undetectable
5eeyG-1y6jA:
undetectable		 5eeyF-1y6jA:
15.48
5eeyG-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 GLY A  14
ALA A  22
THR A  81
ILE A  12
ALA A 239
 None
 1.15A 5eeyO-1y6jA:
undetectable
5eeyP-1y6jA:
undetectable		 5eeyO-1y6jA:
15.48
5eeyP-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 ALA A 239
GLY A  14
ALA A  22
THR A  81
ILE A  12
 None
 1.10A 5eezF-1y6jA:
undetectable
5eezG-1y6jA:
undetectable		 5eezF-1y6jA:
15.48
5eezG-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 GLY A  14
ALA A  22
THR A  81
ILE A  12
ALA A 239
 None
 1.15A 5eezO-1y6jA:
undetectable
5eezP-1y6jA:
undetectable		 5eezO-1y6jA:
15.48
5eezP-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 ALA A 239
GLY A  14
ALA A  22
THR A  81
ILE A  12
 None
 1.10A 5ef0F-1y6jA:
undetectable
5ef0G-1y6jA:
undetectable		 5ef0F-1y6jA:
15.48
5ef0G-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 GLY A  14
ALA A  22
THR A  81
ILE A  12
ALA A 239
 None
 1.15A 5ef0O-1y6jA:
undetectable
5ef0P-1y6jA:
undetectable		 5ef0O-1y6jA:
15.48
5ef0P-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 ALA A 239
GLY A  14
ALA A  22
THR A  81
ILE A  12
 None
 1.10A 5ef1F-1y6jA:
undetectable
5ef1G-1y6jA:
undetectable		 5ef1F-1y6jA:
15.48
5ef1G-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 GLY A  14
ALA A  22
THR A  81
ILE A  12
ALA A 239
 None
 1.14A 5ef1O-1y6jA:
undetectable
5ef1P-1y6jA:
undetectable		 5ef1O-1y6jA:
15.48
5ef1P-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 ALA A 239
GLY A  14
ALA A  22
THR A  81
ILE A  12
 None
 1.10A 5ef2F-1y6jA:
undetectable
5ef2G-1y6jA:
undetectable		 5ef2F-1y6jA:
15.48
5ef2G-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 GLY A  14
ALA A  22
THR A  81
ILE A  12
ALA A 239
 None
 1.15A 5ef2O-1y6jA:
undetectable
5ef2P-1y6jA:
undetectable		 5ef2O-1y6jA:
15.48
5ef2P-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 ALA A 239
GLY A  14
ALA A  22
THR A  81
ILE A  12
 None
 1.10A 5ef3F-1y6jA:
undetectable
5ef3G-1y6jA:
undetectable		 5ef3F-1y6jA:
15.48
5ef3G-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 GLY A  14
ALA A  22
THR A  81
ILE A  12
ALA A 239
 None
 1.14A 5ef3O-1y6jA:
undetectable
5ef3P-1y6jA:
undetectable		 5ef3O-1y6jA:
15.48
5ef3P-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 LYS A  73
GLN A 108
ASN A 109
 None
 1.07A 5l2tA-1y6jA:
undetectable		 5l2tA-1y6jA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 1y6j L-LACTATE
DEHYDROGENASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A  13
ILE A  78
VAL A 106
THR A 107
ILE A 110
 None
 0.93A 6hlpA-1y6jA:
6.1		 6hlpA-1y6jA:
20.23