SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y6l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1y6l UBIQUITIN-CONJUGATIN
G ENZYME E2E2
(Homo
sapiens) 		5 / 12 ILE A  54
ILE A  88
LEU A  89
VAL A  67
ILE A 106
 None
 1.05A 1oipA-1y6lA:
undetectable		 1oipA-1y6lA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 1y6l UBIQUITIN-CONJUGATIN
G ENZYME E2E2
(Homo
sapiens) 		4 / 4 LEU A 110
THR A 111
ILE A 123
HIS A 134
 None
 1.36A 2jfaB-1y6lA:
undetectable		 2jfaB-1y6lA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 1y6l UBIQUITIN-CONJUGATIN
G ENZYME E2E2
(Homo
sapiens) 		5 / 11 ILE A 106
ILE A  99
ILE A  37
ALA A  23
VAL A  67
 None
 0.86A 4h1nA-1y6lA:
undetectable		 4h1nA-1y6lA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1y6l UBIQUITIN-CONJUGATIN
G ENZYME E2E2
(Homo
sapiens) 		4 / 6 LYS A 101
LEU A 104
PRO A  18
ARG A   5
 None
 1.40A 4yv5B-1y6lA:
undetectable		 4yv5B-1y6lA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1y6l UBIQUITIN-CONJUGATIN
G ENZYME E2E2
(Homo
sapiens) 		4 / 6 LYS A 101
LEU A 104
PRO A  18
ARG A   5
 None
 1.44A 4yv5A-1y6lA:
undetectable		 4yv5A-1y6lA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 1y6l UBIQUITIN-CONJUGATIN
G ENZYME E2E2
(Homo
sapiens) 		4 / 5 LEU A  52
LEU A  89
PHE A  69
LEU A 109
 None
 0.99A 5gtrA-1y6lA:
undetectable		 5gtrA-1y6lA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1y6l UBIQUITIN-CONJUGATIN
G ENZYME E2E2
(Homo
sapiens) 		5 / 12 ILE A  54
ILE A  88
LEU A  89
VAL A  67
ILE A 106
 None
 1.03A 5mugA-1y6lA:
undetectable		 5mugA-1y6lA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1y6l UBIQUITIN-CONJUGATIN
G ENZYME E2E2
(Homo
sapiens) 		3 / 3 ILE A  84
VAL A  67
PRO A  65
 None
 0.69A 5uunA-1y6lA:
undetectable		 5uunA-1y6lA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1y6l UBIQUITIN-CONJUGATIN
G ENZYME E2E2
(Homo
sapiens) 		5 / 10 SER A  35
GLY A  24
ILE A  54
ILE A 106
ILE A  37
 None
 1.10A 6ebpD-1y6lA:
undetectable		 6ebpD-1y6lA:
16.78