SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y6n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 1y6n INTERLEUKIN-10
RECEPTOR ALPHA CHAIN
(Homo
sapiens) 		3 / 3 ARG R  78
GLU R   4
SER R  50
 None
 0.84A 2xkkA-1y6nR:
undetectable
2xkkC-1y6nR:
undetectable		 2xkkA-1y6nR:
13.55
2xkkC-1y6nR:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 1y6n INTERLEUKIN-10
RECEPTOR ALPHA CHAIN
(Homo
sapiens) 		3 / 3 GLU R  14
HIS R  20
HIS R  19
 None
 0.80A 3co4A-1y6nR:
undetectable		 3co4A-1y6nR:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1y6n INTERLEUKIN-10
RECEPTOR ALPHA CHAIN
(Homo
sapiens) 		5 / 12 TYR R  70
LEU R 104
PRO R 125
THR R 135
ILE R 139
 None
 1.16A 3g4lC-1y6nR:
undetectable		 3g4lC-1y6nR:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1y6n INTERLEUKIN-10
RECEPTOR ALPHA CHAIN
(Homo
sapiens) 		5 / 12 THR R  57
SER R  59
LEU R  62
VAL R  65
VAL R  38
 None
 1.40A 3u9fH-1y6nR:
undetectable
3u9fI-1y6nR:
undetectable		 3u9fH-1y6nR:
20.93
3u9fI-1y6nR:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1y6n INTERLEUKIN-10
RECEPTOR ALPHA CHAIN
(Homo
sapiens) 		5 / 10 THR R  57
SER R  59
LEU R  62
VAL R  65
VAL R  38
 None
 1.39A 3u9fI-1y6nR:
undetectable		 3u9fI-1y6nR:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1y6n INTERLEUKIN-10
RECEPTOR ALPHA CHAIN
(Homo
sapiens) 		5 / 10 THR R  57
SER R  59
LEU R  62
VAL R  65
VAL R  38
 None
 1.40A 3u9fK-1y6nR:
undetectable		 3u9fK-1y6nR:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_P_CLMP221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1y6n INTERLEUKIN-10
RECEPTOR ALPHA CHAIN
(Homo
sapiens) 		5 / 9 THR R  57
SER R  59
LEU R  62
VAL R  65
VAL R  38
 None
 1.46A 3u9fP-1y6nR:
undetectable		 3u9fP-1y6nR:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1y6n INTERLEUKIN-10
RECEPTOR ALPHA CHAIN
(Homo
sapiens) 		5 / 12 THR R  57
SER R  59
LEU R  62
VAL R  65
VAL R  38
 None
 1.44A 3u9fP-1y6nR:
undetectable
3u9fS-1y6nR:
undetectable		 3u9fP-1y6nR:
20.93
3u9fS-1y6nR:
20.93