SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y6z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 1y6z HEAT SHOCK PROTEIN,
PUTATIVE
(Plasmodium
falciparum) 		5 / 9 TYR A 155
ILE A 158
PHE A  64
ILE A 236
GLU A 234
 None
 1.31A 1mrgA-1y6zA:
undetectable		 1mrgA-1y6zA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 1y6z HEAT SHOCK PROTEIN,
PUTATIVE
(Plasmodium
falciparum) 		4 / 5 SER A 232
ASP A 237
PRO A 235
SER A 206
 None
 1.37A 2hdnA-1y6zA:
undetectable
2hdnB-1y6zA:
undetectable
2hdnD-1y6zA:
undetectable		 2hdnA-1y6zA:
9.24
2hdnB-1y6zA:
22.35
2hdnD-1y6zA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 1y6z HEAT SHOCK PROTEIN,
PUTATIVE
(Plasmodium
falciparum) 		4 / 5 SER A 206
SER A 232
ASP A 237
PRO A 235
 None
 1.39A 2hdnB-1y6zA:
undetectable
2hdnC-1y6zA:
undetectable
2hdnD-1y6zA:
undetectable		 2hdnB-1y6zA:
22.35
2hdnC-1y6zA:
9.24
2hdnD-1y6zA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1y6z HEAT SHOCK PROTEIN,
PUTATIVE
(Plasmodium
falciparum) 		4 / 8 ASN A  46
SER A  47
PHE A  45
PHE A  84
 None
 1.03A 2wekA-1y6zA:
undetectable		 2wekA-1y6zA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1y6z HEAT SHOCK PROTEIN,
PUTATIVE
(Plasmodium
falciparum) 		4 / 8 ASN A  46
SER A  47
PHE A  45
PHE A  84
 None
 1.03A 2wekB-1y6zA:
undetectable		 2wekB-1y6zA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 1y6z HEAT SHOCK PROTEIN,
PUTATIVE
(Plasmodium
falciparum) 		3 / 3 MET A 134
VAL A 174
GLU A 169
 None
 0.87A 3c6gA-1y6zA:
undetectable		 3c6gA-1y6zA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1y6z HEAT SHOCK PROTEIN,
PUTATIVE
(Plasmodium
falciparum) 		5 / 12 SER A  87
PHE A  84
SER A 120
VAL A  39
PHE A  37
 None
 1.44A 3u9fB-1y6zA:
undetectable
3u9fC-1y6zA:
undetectable		 3u9fB-1y6zA:
18.55
3u9fC-1y6zA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 1y6z HEAT SHOCK PROTEIN,
PUTATIVE
(Plasmodium
falciparum) 		3 / 3 ASP A 100
ARG A  77
TYR A  74
 None
 1.00A 5a7mA-1y6zA:
undetectable		 5a7mA-1y6zA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 1y6z HEAT SHOCK PROTEIN,
PUTATIVE
(Plasmodium
falciparum) 		3 / 3 ASP A 100
ARG A  77
TYR A  74
 None
 1.00A 5a7mB-1y6zA:
undetectable		 5a7mB-1y6zA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1y6z HEAT SHOCK PROTEIN,
PUTATIVE
(Plasmodium
falciparum) 		4 / 5 LEU A 244
TYR A 252
LYS A 250
LEU A 188
 None
 1.02A 5weaA-1y6zA:
undetectable		 5weaA-1y6zA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 1y6z HEAT SHOCK PROTEIN,
PUTATIVE
(Plasmodium
falciparum) 		5 / 11 VAL A 160
ALA A 171
SER A 243
LEU A 244
ASN A 247
 None
 1.15A 5x6yA-1y6zA:
undetectable		 5x6yA-1y6zA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 1y6z HEAT SHOCK PROTEIN,
PUTATIVE
(Plasmodium
falciparum) 		5 / 11 VAL A 160
ALA A 171
SER A 243
LEU A 244
ASN A 247
 None
 1.19A 5x6yC-1y6zA:
undetectable		 5x6yC-1y6zA:
16.58