SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y74'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ROX_A_TEPA266_1 (APOLIPOPROTEIN A-I-BINDING PROTEIN)	1y74	LIN 7 HOMOLOG B (Mus musculus)	4 / 8	ALA A 26 VAL A 23 ASP A 22 LEU A 19	None	0.80A	3roxA-1y74A: undetectable	3roxA-1y74A: 11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K50_A_ACTA502_0 (RNA POLYMERASE 3D-POL)	1y74	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK (Mus musculus)	3 / 3	ARG B 108 LYS B 104 LYS B 107	None	1.22A	4k50A-1y74B: undetectable	4k50A-1y74B: 8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K50_E_ACTE502_0 (RNA POLYMERASE 3D-POL)	1y74	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK (Mus musculus)	3 / 3	ARG B 108 LYS B 104 LYS B 107	None	1.05A	4k50E-1y74B: undetectable	4k50E-1y74B: 8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K50_I_ACTI506_0 (RNA POLYMERASE 3D-POL)	1y74	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK (Mus musculus)	3 / 3	ARG B 108 LYS B 104 LYS B 107	None	1.14A	4k50I-1y74B: undetectable	4k50I-1y74B: 8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L3G_F_ACTF401_0 (METHYLAMINE DEHYDROGENASE HEAVY CHAIN)	1y74	LIN 7 HOMOLOG B (Mus musculus)	3 / 3	ARG A 25 LEU A 29 GLU A 28	None	0.71A	4l3gF-1y74A: undetectable	4l3gF-1y74A: 12.08

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3ROX_A_TEPA266_1","APOLIPOPROTEIN A-I-BINDING PROTEIN","1y74","LIN 7 HOMOLOG B","Mus musculus",4,"ALA A  26;VAL A  23;ASP A  22;LEU A  19","None","0.80A","3roxA-1y74A:undetectable","3roxA-1y74A:11.88"],["4K50_A_ACTA502_0","RNA POLYMERASE 3D-POL","1y74","PERIPHERAL PLASMA MEMBRANE PROTEIN CASK","Mus musculus",3,"ARG B 108;LYS B 104;LYS B 107","None","1.22A","4k50A-1y74B:undetectable","4k50A-1y74B:8.35"],["4K50_E_ACTE502_0","RNA POLYMERASE 3D-POL","1y74","PERIPHERAL PLASMA MEMBRANE PROTEIN CASK","Mus musculus",3,"ARG B 108;LYS B 104;LYS B 107","None","1.05A","4k50E-1y74B:undetectable","4k50E-1y74B:8.35"],["4K50_I_ACTI506_0","RNA POLYMERASE 3D-POL","1y74","PERIPHERAL PLASMA MEMBRANE PROTEIN CASK","Mus musculus",3,"ARG B 108;LYS B 104;LYS B 107","None","1.14A","4k50I-1y74B:undetectable","4k50I-1y74B:8.35"],["4L3G_F_ACTF401_0","METHYLAMINE DEHYDROGENASE HEAVY CHAIN","1y74","LIN 7 HOMOLOG B","Mus musculus",3,"ARG A  25;LEU A  29;GLU A  28","None","0.71A","4l3gF-1y74A:undetectable","4l3gF-1y74A:12.08"]]