SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y75'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 1y75 PHOSPHOLIPASE A2
ISOFORM 6
(Naja
sagittifera) 		4 / 4 HIS B  48
ASP B  42
SER B  36
ASP B  49
 None
 1.48A 1n2xA-1y75B:
undetectable		 1n2xA-1y75B:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 1y75 PHOSPHOLIPASE A2
ISOFORM 5
(Naja
sagittifera) 		4 / 4 VAL A  13
ALA A 102
LEU A  41
PHE A 101
 None
 1.24A 1q97B-1y75A:
undetectable		 1q97B-1y75A:
12.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TD7_A_NFLA2001_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 1y75 PHOSPHOLIPASE A2
ISOFORM 5
(Naja
sagittifera) 		5 / 9 ILE A   9
TRP A  19
PHE A  22
GLY A  30
PHE A 101
 None
NAG  A 301 (-4.7A)
None
NAG  A 301 (-4.0A)
None
 0.37A 1td7A-1y75A:
22.8		 1td7A-1y75A:
86.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TH6_A_OINA401_1
(PHOSPHOLIPASE A2)		 1y75 PHOSPHOLIPASE A2
ISOFORM 6
(Naja
sagittifera) 		5 / 7 GLY B  30
HIS B  48
ASP B  49
TYR B  52
PRO B  63
 None
 0.73A 1th6A-1y75B:
17.9		 1th6A-1y75B:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ARM_A_OINA401_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1y75 PHOSPHOLIPASE A2
ISOFORM 6
(Naja
sagittifera) 		5 / 7 GLY B  30
HIS B  48
ASP B  49
TYR B  52
PRO B  63
 None
 0.74A 2armA-1y75B:
17.9		 2armA-1y75B:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 1y75 PHOSPHOLIPASE A2
ISOFORM 5
(Naja
sagittifera) 		5 / 11 ILE A   9
TYR A  25
GLY A  30
LEU A  41
PHE A 101
 None
None
NAG  A 301 (-4.0A)
None
None
 0.41A 2azyA-1y75A:
18.6		 2azyA-1y75A:
51.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 1y75 PHOSPHOLIPASE A2
ISOFORM 6
(Naja
sagittifera) 		6 / 11 ILE B   9
TYR B  25
GLY B  30
LEU B  41
PHE B 101
TYR B 106
 None
 0.60A 2azyA-1y75B:
18.7		 2azyA-1y75B:
47.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1y75 PHOSPHOLIPASE A2
ISOFORM 5
(Naja
sagittifera) 		4 / 6 ALA A  23
HIS A  48
TYR A  52
LYS A  64
 None
NAG  A 301 (-3.9A)
None
NAG  A 301 (-2.8A)
 0.98A 2dpzA-1y75A:
17.6		 2dpzA-1y75A:
37.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1y75 PHOSPHOLIPASE A2
ISOFORM 6
(Naja
sagittifera) 		4 / 6 ALA B  23
HIS B  48
TYR B  52
LYS B  64
 None
 0.91A 2dpzA-1y75B:
18.1		 2dpzA-1y75B:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1y75 PHOSPHOLIPASE A2
ISOFORM 6
(Naja
sagittifera) 		4 / 6 HIS B  48
ASP B  49
TYR B  52
LYS B  64
 None
 0.46A 2dpzA-1y75B:
18.1		 2dpzA-1y75B:
36.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 1y75 PHOSPHOLIPASE A2
ISOFORM 6
(Naja
sagittifera) 		4 / 4 VAL B  90
THR B  89
VAL B  58
GLY B  56
 None
 1.16A 2p2fB-1y75B:
undetectable		 2p2fB-1y75B:
10.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FO7_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1y75 PHOSPHOLIPASE A2
ISOFORM 6
(Naja
sagittifera) 		4 / 5 HIS B  48
ASP B  49
TYR B  52
PRO B  63
 None
 0.49A 3fo7A-1y75B:
18.0		 3fo7A-1y75B:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H1X_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1y75 PHOSPHOLIPASE A2
ISOFORM 5
(Naja
sagittifera) 		4 / 5 HIS A  48
TYR A  52
PRO A  63
LYS A  64
 NAG  A 301 (-3.9A)
None
None
NAG  A 301 (-2.8A)
 0.91A 3h1xA-1y75A:
17.7		 3h1xA-1y75A:
37.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H1X_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1y75 PHOSPHOLIPASE A2
ISOFORM 6
(Naja
sagittifera) 		5 / 5 HIS B  48
ASP B  49
TYR B  52
PRO B  63
LYS B  64
 None
 0.70A 3h1xA-1y75B:
17.9		 3h1xA-1y75B:
36.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 1y75 PHOSPHOLIPASE A2
ISOFORM 6
(Naja
sagittifera) 		3 / 3 ASP B  49
ASN B  50
SER B  31
 None
 0.85A 3lslA-1y75B:
undetectable
3lslD-1y75B:
undetectable		 3lslA-1y75B:
16.67
3lslD-1y75B:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 1y75 PHOSPHOLIPASE A2
ISOFORM 6
(Naja
sagittifera) 		3 / 3 SER B  31
ASP B  49
ASN B  50
 None
 0.79A 3lslA-1y75B:
undetectable
3lslD-1y75B:
undetectable		 3lslA-1y75B:
16.67
3lslD-1y75B:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OSH_A_OINA5811_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 1y75 PHOSPHOLIPASE A2
ISOFORM 5
(Naja
sagittifera) 		6 / 9 PHE A   5
ILE A   9
TRP A  19
PHE A  22
GLY A  30
HIS A  48
 NAG  A 301 (-4.2A)
None
NAG  A 301 (-4.7A)
None
NAG  A 301 (-4.0A)
NAG  A 301 (-3.9A)
 0.36A 3oshA-1y75A:
23.1		 3oshA-1y75A:
85.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OSH_A_OINA5811_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 1y75 PHOSPHOLIPASE A2
ISOFORM 6
(Naja
sagittifera) 		6 / 9 PHE B   5
ILE B   9
TRP B  19
PHE B  22
GLY B  30
HIS B  48
 None
 0.82A 3oshA-1y75B:
22.4		 3oshA-1y75B:
77.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 1y75 PHOSPHOLIPASE A2
ISOFORM 5
PHOSPHOLIPASE A2
ISOFORM 6
(Naja
sagittifera;
Naja
sagittifera) 		3 / 3 TYR A 106
ASP B 114
ASP A  21
 None
 0.76A 3r24A-1y75A:
undetectable		 3r24A-1y75A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 1y75 PHOSPHOLIPASE A2
ISOFORM 5
PHOSPHOLIPASE A2
ISOFORM 6
(Naja
sagittifera;
Naja
sagittifera) 		3 / 3 TYR B 106
ASP A 114
ASP B  21
 None
 0.75A 3r24A-1y75B:
undetectable		 3r24A-1y75B:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 1y75 PHOSPHOLIPASE A2
ISOFORM 5
PHOSPHOLIPASE A2
ISOFORM 6
(Naja
sagittifera) 		3 / 3 ASP A  24
ASP B  24
ASN B 110
 ZN  A 401 (-2.1A)
ZN  A 401 (-2.1A)
None
 0.56A 4q5mA-1y75A:
undetectable		 4q5mA-1y75A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 1y75 PHOSPHOLIPASE A2
ISOFORM 5
PHOSPHOLIPASE A2
ISOFORM 6
(Naja
sagittifera) 		3 / 3 ASP B  24
ASP A  24
ASN A 110
 ZN  A 401 (-2.1A)
ZN  A 401 (-2.1A)
None
 0.60A 4q5mA-1y75B:
undetectable		 4q5mA-1y75B:
16.59