SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y79'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 8 GLU 1 130
LEU 1 134
GLU 1  62
LEU 1 435
 None
 1.07A 1cmaA-1y791:
undetectable
1cmaB-1y791:
undetectable		 1cmaA-1y791:
9.01
1cmaB-1y791:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 5 LEU 1 551
GLU 1 583
ALA 1 554
LEU 1 550
 None
None
None
ASP  1 704 ( 4.7A)
 1.21A 1eta1-1y791:
undetectable		 1eta1-1y791:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 7 LEU 1 221
THR 1 223
GLY 1 245
LEU 1 241
 None
 0.78A 1gtiB-1y791:
2.3		 1gtiB-1y791:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		8 / 12 THR 1 466
HIS 1 469
GLU 1 470
HIS 1 473
GLU 1 498
HIS 1 601
TYR 1 611
TYR 1 614
 GLY  1 703 ( 4.6A)
ZN  1 700 (-3.2A)
TRP  1 702 ( 2.6A)
ZN  1 700 ( 3.3A)
ZN  1 700 ( 2.2A)
TRP  1 702 ( 3.8A)
ASP  1 704 (-4.7A)
ASP  1 704 (-3.5A)
 0.41A 1j36A-1y791:
19.7		 1j36A-1y791:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		8 / 12 THR 1 466
HIS 1 469
GLU 1 470
HIS 1 473
GLU 1 498
HIS 1 601
TYR 1 611
TYR 1 614
 GLY  1 703 ( 4.6A)
ZN  1 700 (-3.2A)
TRP  1 702 ( 2.6A)
ZN  1 700 ( 3.3A)
ZN  1 700 ( 2.2A)
TRP  1 702 ( 3.8A)
ASP  1 704 (-4.7A)
ASP  1 704 (-3.5A)
 0.41A 1j36B-1y791:
19.8		 1j36B-1y791:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		7 / 11 HIS 1 469
GLU 1 470
HIS 1 473
GLU 1 498
HIS 1 601
TYR 1 611
TYR 1 614
 ZN  1 700 (-3.2A)
TRP  1 702 ( 2.6A)
ZN  1 700 ( 3.3A)
ZN  1 700 ( 2.2A)
TRP  1 702 ( 3.8A)
ASP  1 704 (-4.7A)
ASP  1 704 (-3.5A)
 0.45A 1j37A-1y791:
19.7		 1j37A-1y791:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		7 / 11 HIS 1 469
GLU 1 470
HIS 1 473
GLU 1 498
HIS 1 601
TYR 1 611
TYR 1 614
 ZN  1 700 (-3.2A)
TRP  1 702 ( 2.6A)
ZN  1 700 ( 3.3A)
ZN  1 700 ( 2.2A)
TRP  1 702 ( 3.8A)
ASP  1 704 (-4.7A)
ASP  1 704 (-3.5A)
 0.44A 1j37B-1y791:
19.7		 1j37B-1y791:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1866_0
(FPRA)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 4 ARG 1 141
LEU 1 487
ASN 1 491
VAL 1 137
 None
 1.44A 1lqtA-1y791:
2.4		 1lqtA-1y791:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1875_0
(FPRA)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 4 ARG 1 141
LEU 1 487
ASN 1 491
VAL 1 137
 None
 1.41A 1lqtB-1y791:
2.9		 1lqtB-1y791:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1423_0
(FPRA)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 4 ARG 1 141
LEU 1 487
ASN 1 491
VAL 1 137
 None
 1.43A 1lquA-1y791:
2.5		 1lquA-1y791:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1432_0
(FPRA)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 4 ARG 1 141
LEU 1 487
ASN 1 491
VAL 1 137
 None
 1.40A 1lquB-1y791:
2.2		 1lquB-1y791:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		3 / 3 ARG 1 248
ILE 1 243
TRP 1 246
 None
 1.16A 1nodB-1y791:
undetectable		 1nodB-1y791:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		7 / 12 HIS 1 469
GLU 1 470
HIS 1 473
GLU 1 498
HIS 1 601
TYR 1 611
TYR 1 614
 ZN  1 700 (-3.2A)
TRP  1 702 ( 2.6A)
ZN  1 700 ( 3.3A)
ZN  1 700 ( 2.2A)
TRP  1 702 ( 3.8A)
ASP  1 704 (-4.7A)
ASP  1 704 (-3.5A)
 0.32A 1o86A-1y791:
20.5		 1o86A-1y791:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		3 / 3 ARG 1 268
TYR 1 280
LYS 1 284
 None
 0.81A 1uujB-1y791:
1.0		 1uujB-1y791:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 8 GLU 1 498
HIS 1 469
HIS 1 473
GLU 1 470
 ZN  1 700 ( 2.2A)
ZN  1 700 (-3.2A)
ZN  1 700 ( 3.3A)
TRP  1 702 ( 2.6A)
 0.89A 1v7zA-1y791:
undetectable		 1v7zA-1y791:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 8 GLU 1 498
HIS 1 469
HIS 1 473
GLU 1 470
 ZN  1 700 ( 2.2A)
ZN  1 700 (-3.2A)
ZN  1 700 ( 3.3A)
TRP  1 702 ( 2.6A)
 0.90A 1v7zB-1y791:
undetectable		 1v7zB-1y791:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 8 GLU 1 498
HIS 1 469
HIS 1 473
GLU 1 470
 ZN  1 700 ( 2.2A)
ZN  1 700 (-3.2A)
ZN  1 700 ( 3.3A)
TRP  1 702 ( 2.6A)
 0.90A 1v7zC-1y791:
undetectable		 1v7zC-1y791:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 8 GLU 1 498
HIS 1 469
HIS 1 473
GLU 1 470
 ZN  1 700 ( 2.2A)
ZN  1 700 (-3.2A)
ZN  1 700 ( 3.3A)
TRP  1 702 ( 2.6A)
 0.92A 1v7zD-1y791:
undetectable		 1v7zD-1y791:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 8 GLU 1 498
HIS 1 469
HIS 1 473
GLU 1 470
 ZN  1 700 ( 2.2A)
ZN  1 700 (-3.2A)
ZN  1 700 ( 3.3A)
TRP  1 702 ( 2.6A)
 0.92A 1v7zE-1y791:
undetectable		 1v7zE-1y791:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 8 GLU 1 498
HIS 1 469
HIS 1 473
GLU 1 470
 ZN  1 700 ( 2.2A)
ZN  1 700 (-3.2A)
ZN  1 700 ( 3.3A)
TRP  1 702 ( 2.6A)
 0.90A 1v7zF-1y791:
undetectable		 1v7zF-1y791:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		8 / 12 ALA 1 424
HIS 1 469
GLU 1 470
HIS 1 473
GLU 1 498
HIS 1 601
TYR 1 611
TYR 1 614
 GLY  1 703 (-4.8A)
ZN  1 700 (-3.2A)
TRP  1 702 ( 2.6A)
ZN  1 700 ( 3.3A)
ZN  1 700 ( 2.2A)
TRP  1 702 ( 3.8A)
ASP  1 704 (-4.7A)
ASP  1 704 (-3.5A)
 0.38A 2c6nA-1y791:
19.8		 2c6nA-1y791:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		7 / 12 HIS 1 469
GLU 1 470
HIS 1 473
GLU 1 498
HIS 1 601
TYR 1 611
TYR 1 614
 ZN  1 700 (-3.2A)
TRP  1 702 ( 2.6A)
ZN  1 700 ( 3.3A)
ZN  1 700 ( 2.2A)
TRP  1 702 ( 3.8A)
ASP  1 704 (-4.7A)
ASP  1 704 (-3.5A)
 0.38A 2c6nB-1y791:
19.8		 2c6nB-1y791:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 8 THR 1 466
HIS 1 469
GLU 1 470
HIS 1 473
 GLY  1 703 ( 4.6A)
ZN  1 700 (-3.2A)
TRP  1 702 ( 2.6A)
ZN  1 700 ( 3.3A)
 0.24A 2jihB-1y791:
undetectable		 2jihB-1y791:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		3 / 3 ARG 1 248
ILE 1 243
TRP 1 246
 None
 1.15A 2nodB-1y791:
undetectable		 2nodB-1y791:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R6V_A_NCAA174_0
(UNCHARACTERIZED
PROTEIN PH0856)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 6 TYR 1 659
ASP 1 623
ARG 1 676
HIS 1 506
 None
 1.31A 2r6vA-1y791:
0.0		 2r6vA-1y791:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 7 LEU 1 221
ASN 1 222
LEU 1 176
TYR 1 448
 None
 1.27A 2w8yA-1y791:
undetectable		 2w8yA-1y791:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		7 / 11 HIS 1 469
GLU 1 470
HIS 1 473
GLU 1 498
HIS 1 601
TYR 1 611
TYR 1 614
 ZN  1 700 (-3.2A)
TRP  1 702 ( 2.6A)
ZN  1 700 ( 3.3A)
ZN  1 700 ( 2.2A)
TRP  1 702 ( 3.8A)
ASP  1 704 (-4.7A)
ASP  1 704 (-3.5A)
 0.32A 2x8zA-1y791:
19.7		 2x8zA-1y791:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		7 / 12 HIS 1 469
GLU 1 470
HIS 1 473
GLU 1 498
HIS 1 601
TYR 1 611
TYR 1 614
 ZN  1 700 (-3.2A)
TRP  1 702 ( 2.6A)
ZN  1 700 ( 3.3A)
ZN  1 700 ( 2.2A)
TRP  1 702 ( 3.8A)
ASP  1 704 (-4.7A)
ASP  1 704 (-3.5A)
 0.30A 2x91A-1y791:
19.9		 2x91A-1y791:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1305_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 5 SER 1 597
ARG 1 248
GLY 1 245
TRP 1 246
 None
 1.36A 2y7kB-1y791:
0.0		 2y7kB-1y791:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 8 GLU 1 498
HIS 1 469
HIS 1 473
GLU 1 470
 ZN  1 700 ( 2.2A)
ZN  1 700 (-3.2A)
ZN  1 700 ( 3.3A)
TRP  1 702 ( 2.6A)
 0.89A 3a6jA-1y791:
undetectable		 3a6jA-1y791:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 7 GLU 1 498
HIS 1 469
HIS 1 473
GLU 1 470
 ZN  1 700 ( 2.2A)
ZN  1 700 (-3.2A)
ZN  1 700 ( 3.3A)
TRP  1 702 ( 2.6A)
 0.86A 3a6jB-1y791:
undetectable		 3a6jB-1y791:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 8 GLU 1 498
HIS 1 469
HIS 1 473
GLU 1 470
 ZN  1 700 ( 2.2A)
ZN  1 700 (-3.2A)
ZN  1 700 ( 3.3A)
TRP  1 702 ( 2.6A)
 0.87A 3a6jC-1y791:
undetectable		 3a6jC-1y791:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 8 GLU 1 498
HIS 1 469
HIS 1 473
GLU 1 470
 ZN  1 700 ( 2.2A)
ZN  1 700 (-3.2A)
ZN  1 700 ( 3.3A)
TRP  1 702 ( 2.6A)
 0.90A 3a6jE-1y791:
undetectable		 3a6jE-1y791:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 8 GLU 1 498
HIS 1 469
HIS 1 473
GLU 1 470
 ZN  1 700 ( 2.2A)
ZN  1 700 (-3.2A)
ZN  1 700 ( 3.3A)
TRP  1 702 ( 2.6A)
 0.86A 3a6jF-1y791:
undetectable		 3a6jF-1y791:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		3 / 3 ARG 1 248
ILE 1 243
TRP 1 246
 None
 1.10A 3e7iB-1y791:
undetectable		 3e7iB-1y791:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		3 / 3 ARG 1 248
GLU 1 576
ASP 1 586
 None
 0.74A 3g2oA-1y791:
undetectable		 3g2oA-1y791:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		3 / 3 HIS 1 469
GLU 1 470
HIS 1 473
 ZN  1 700 (-3.2A)
TRP  1 702 ( 2.6A)
ZN  1 700 ( 3.3A)
 0.16A 3kecB-1y791:
4.6		 3kecB-1y791:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 7 GLU 1 549
TYR 1 598
TYR 1 594
TYR 1 611
 None
None
ASP  1 704 (-4.1A)
ASP  1 704 (-4.7A)
 1.27A 3ku9B-1y791:
undetectable		 3ku9B-1y791:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		3 / 3 ARG 1 248
ILE 1 243
TRP 1 246
 None
 1.12A 3nw2B-1y791:
undetectable		 3nw2B-1y791:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 8 GLN 1  63
TYR 1 484
GLN 1 432
GLU 1 431
 None
 0.98A 3oyaA-1y791:
undetectable		 3oyaA-1y791:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		5 / 12 GLY 1 477
HIS 1 473
ARG 1 649
SER 1 488
GLN 1 482
 None
ZN  1 700 ( 3.3A)
None
None
None
 1.33A 3tkaA-1y791:
undetectable		 3tkaA-1y791:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 7 ASN 1   4
ALA 1  30
PRO 1  29
TYR 1  27
 None
 0.80A 3twpA-1y791:
2.7		 3twpA-1y791:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 7 ASN 1   4
ALA 1  30
PRO 1  29
TYR 1  27
 None
 0.81A 3twpB-1y791:
2.6		 3twpB-1y791:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 7 ASN 1   4
ALA 1  30
PRO 1  29
TYR 1  27
 None
 0.81A 3twpC-1y791:
2.1		 3twpC-1y791:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 5 ASN 1   4
ALA 1  30
PRO 1  29
TYR 1  27
 None
 0.80A 3twpD-1y791:
undetectable		 3twpD-1y791:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 7 TYR 1 659
ASP 1 623
ARG 1 676
HIS 1 506
 None
 1.30A 3zodA-1y791:
undetectable		 3zodA-1y791:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		7 / 11 HIS 1 469
GLU 1 470
HIS 1 473
GLU 1 498
HIS 1 601
TYR 1 611
TYR 1 614
 ZN  1 700 (-3.2A)
TRP  1 702 ( 2.6A)
ZN  1 700 ( 3.3A)
ZN  1 700 ( 2.2A)
TRP  1 702 ( 3.8A)
ASP  1 704 (-4.7A)
ASP  1 704 (-3.5A)
 0.49A 4c2pA-1y791:
4.4		 4c2pA-1y791:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 6 LEU 1 550
HIS 1 469
TYR 1 607
GLU 1 498
 ASP  1 704 ( 4.7A)
ZN  1 700 (-3.2A)
LYS  1 701 (-4.1A)
ZN  1 700 ( 2.2A)
 1.03A 4pahA-1y791:
undetectable		 4pahA-1y791:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		5 / 12 THR 1 490
GLY 1 650
SER 1 501
HIS 1 473
ASN 1 491
 None
None
ZN  1 700 (-3.6A)
ZN  1 700 ( 3.3A)
None
 1.36A 4pooB-1y791:
undetectable		 4pooB-1y791:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		5 / 12 HIS 1 469
GLU 1 470
HIS 1 473
GLU 1 498
TYR 1 614
 ZN  1 700 (-3.2A)
TRP  1 702 ( 2.6A)
ZN  1 700 ( 3.3A)
ZN  1 700 ( 2.2A)
ASP  1 704 (-3.5A)
 0.51A 4r7lA-1y791:
6.9		 4r7lA-1y791:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 7 PRO 1 671
TRP 1 461
ASP 1 462
THR 1 466
 None
None
None
GLY  1 703 ( 4.6A)
 1.18A 4uacA-1y791:
undetectable		 4uacA-1y791:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		5 / 10 LEU 1 478
LEU 1 407
SER 1 648
ALA 1 373
ILE 1 399
 None
 1.03A 4xj7C-1y791:
undetectable
4xj7D-1y791:
undetectable		 4xj7C-1y791:
17.67
4xj7D-1y791:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		3 / 3 VAL 1  71
TYR 1  27
ALA 1  30
 None
 0.41A 4ybnA-1y791:
0.0		 4ybnA-1y791:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_B_QELB503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		5 / 11 TYR 1 280
LEU 1 275
PRO 1 293
ALA 1 286
ILE 1 285
 None
 1.08A 5ewjA-1y791:
2.5
5ewjB-1y791:
undetectable		 5ewjA-1y791:
21.14
5ewjB-1y791:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 7 ASP 1 495
TYR 1 612
GLY 1 610
TYR 1 280
 None
 1.00A 5hwaA-1y791:
undetectable		 5hwaA-1y791:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 7 LEU 1  90
PHE 1  94
SER 1 169
GLU 1  97
 None
 1.06A 5n5dA-1y791:
undetectable		 5n5dA-1y791:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		5 / 12 ASP 1 104
GLU 1 100
LEU 1  67
PHE 1  31
LEU 1  98
 None
 1.33A 5nd2B-1y791:
undetectable		 5nd2B-1y791:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		3 / 3 THR 1 247
PRO 1 592
ARG 1 593
 None
None
ASP  1 704 (-3.9A)
 0.74A 5nd7B-1y791:
undetectable		 5nd7B-1y791:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 6 LEU 1 647
SER 1 648
PHE 1 479
HIS 1 402
 None
 0.82A 5om3A-1y791:
undetectable
5om3B-1y791:
undetectable		 5om3A-1y791:
8.55
5om3B-1y791:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 8 PRO 1 591
THR 1 223
THR 1 224
ALA 1 337
 None
 1.04A 5x2tI-1y791:
undetectable
5x2tJ-1y791:
undetectable
5x2tK-1y791:
undetectable
5x2tL-1y791:
undetectable		 5x2tI-1y791:
11.60
5x2tJ-1y791:
12.72
5x2tK-1y791:
11.60
5x2tL-1y791:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		5 / 12 SER 1  64
LYS 1  38
ILE 1 138
LEU 1 134
LEU 1 435
 None
 1.41A 5zwrB-1y791:
undetectable		 5zwrB-1y791:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_0
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		5 / 12 GLN 1  88
THR 1  79
THR 1  72
LEU 1  98
SER 1 169
 None
 1.46A 6ak3A-1y791:
1.7		 6ak3A-1y791:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_0
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		5 / 12 GLN 1  88
THR 1  79
THR 1  72
LEU 1  98
SER 1 169
 None
 1.45A 6ak3B-1y791:
0.0		 6ak3B-1y791:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 6 PHE 1 479
ARG 1 481
ARG 1 649
LEU 1 647
 None
 0.94A 6b89B-1y791:
undetectable		 6b89B-1y791:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		5 / 12 VAL 1 369
VAL 1 389
PHE 1 370
PHE 1 471
ILE 1 387
 None
 1.11A 6becA-1y791:
0.0
6becB-1y791:
0.0
6becC-1y791:
0.0		 6becA-1y791:
19.67
6becB-1y791:
19.67
6becC-1y791:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 1y79 PEPTIDYL-DIPEPTIDASE
DCP
(Escherichia
coli) 		4 / 6 LEU 1 550
HIS 1 469
TYR 1 607
GLU 1 498
 ASP  1 704 ( 4.7A)
ZN  1 700 (-3.2A)
LYS  1 701 (-4.1A)
ZN  1 700 ( 2.2A)
 1.06A 6pahA-1y791:
undetectable		 6pahA-1y791:
18.17