SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y7e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 1y7e PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Borreliella
burgdorferi) 		4 / 8 ILE A 221
PRO A 107
ILE A 117
ILE A 194
 None
 0.70A 1hshD-1y7eA:
undetectable		 1hshD-1y7eA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1y7e PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Borreliella
burgdorferi) 		4 / 7 LEU A  10
TYR A 446
LEU A  19
GLN A  17
 None
 0.96A 1kt3A-1y7eA:
undetectable		 1kt3A-1y7eA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 1y7e PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Borreliella
burgdorferi) 		3 / 3 ALA A 448
THR A 262
PHE A 443
 None
 0.76A 2c6nB-1y7eA:
undetectable		 2c6nB-1y7eA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1y7e PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Borreliella
burgdorferi) 		4 / 6 ALA A 251
TYR A  25
ILE A 439
ILE A 249
 None
 1.25A 2dcfA-1y7eA:
undetectable		 2dcfA-1y7eA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 1y7e PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Borreliella
burgdorferi) 		4 / 4 PRO A  99
ASP A  97
ASP A 297
ASP A 335
 None
 1.48A 2nyuA-1y7eA:
undetectable		 2nyuA-1y7eA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1y7e PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Borreliella
burgdorferi) 		4 / 7 PHE A 268
LEU A  43
ALA A  46
PHE A  51
 None
 0.83A 2vcvL-1y7eA:
undetectable		 2vcvL-1y7eA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1y7e PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Borreliella
burgdorferi) 		5 / 9 ALA A 251
TYR A  25
ILE A 439
GLY A 250
ILE A 249
 None
 1.28A 2zm9A-1y7eA:
0.0		 2zm9A-1y7eA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 1y7e PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Borreliella
burgdorferi) 		5 / 9 ILE A 221
ILE A 215
VAL A 141
ILE A 137
ILE A 231
 None
 1.21A 3p4wB-1y7eA:
undetectable		 3p4wB-1y7eA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 1y7e PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Borreliella
burgdorferi) 		5 / 10 ILE A 221
ILE A 215
VAL A 141
ILE A 137
ILE A 231
 None
 1.22A 3p4wD-1y7eA:
undetectable		 3p4wD-1y7eA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 1y7e PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Borreliella
burgdorferi) 		5 / 10 ILE A 221
ILE A 215
VAL A 141
ILE A 137
ILE A 231
 None
 1.21A 3p4wE-1y7eA:
undetectable		 3p4wE-1y7eA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 1y7e PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Borreliella
burgdorferi) 		6 / 9 ALA A 103
ASP A 102
ILE A 233
GLY A 139
ILE A 194
ILE A 117
 None
 1.35A 3s45A-1y7eA:
undetectable		 3s45A-1y7eA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1y7e PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Borreliella
burgdorferi) 		5 / 8 HIS A  95
ASP A  97
LYS A 285
TYR A 122
ASP A 255
 None
 1.25A 4k0bB-1y7eA:
undetectable		 4k0bB-1y7eA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1y7e PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Borreliella
burgdorferi) 		5 / 8 HIS A  95
ASP A  97
LYS A 285
TYR A 122
ASP A 255
 None
 1.27A 4l7iB-1y7eA:
undetectable		 4l7iB-1y7eA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 1y7e PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Borreliella
burgdorferi) 		4 / 4 LEU A 135
SER A 132
LEU A 193
LEU A 101
 None
 1.04A 4n09A-1y7eA:
2.2		 4n09A-1y7eA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 1y7e PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Borreliella
burgdorferi) 		5 / 12 ASN A  90
ILE A  92
ASP A 256
ALA A 334
ILE A 332
 None
 1.17A 4uroC-1y7eA:
undetectable		 4uroC-1y7eA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1y7e PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Borreliella
burgdorferi) 		4 / 9 ILE A  29
PHE A  28
THR A 440
ILE A 258
 None
 0.94A 5lg3I-1y7eA:
undetectable		 5lg3I-1y7eA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1y7e PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Borreliella
burgdorferi) 		5 / 12 ILE A  85
PHE A 310
ALA A 325
MET A  89
VAL A 305
 None
 1.11A 5n0rA-1y7eA:
undetectable		 5n0rA-1y7eA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1y7e PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Borreliella
burgdorferi) 		5 / 12 ILE A  85
PHE A 310
ALA A 325
MET A  89
VAL A 305
 None
 1.08A 5n0sA-1y7eA:
undetectable		 5n0sA-1y7eA:
20.20