SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y7i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum)
3 / 4 LYS A  93
ALA A  90
MET A  63
None
1.01A 1hk3A-1y7iA:
undetectable
1hk3A-1y7iA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum)
4 / 4 GLY A  12
VAL A  10
TRP A  18
GLY A  17
SAL  A 501 ( 3.9A)
None
None
None
0.84A 1ng8A-1y7iA:
undetectable
1ng8A-1y7iA:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum)
4 / 4 GLY A  12
VAL A  10
TRP A  18
GLY A  17
SAL  A 501 ( 3.9A)
None
None
None
0.84A 1ng8B-1y7iA:
undetectable
1ng8B-1y7iA:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum)
5 / 10 ASP A 185
LEU A 186
SER A 115
THR A  54
THR A  59
None
1.30A 1rqpA-1y7iA:
3.2
1rqpA-1y7iA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum)
5 / 10 ASP A 185
LEU A 186
SER A 115
THR A  54
THR A  59
None
1.31A 1rqpB-1y7iA:
0.9
1rqpB-1y7iA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum)
5 / 10 ASP A 185
LEU A 186
SER A 115
THR A  54
THR A  59
None
1.26A 1rqpC-1y7iA:
3.2
1rqpC-1y7iA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum)
4 / 5 LEU A 160
PHE A 136
MET A 149
SER A 179
None
None
SAL  A 501 ( 4.6A)
None
1.22A 1wrlC-1y7iA:
undetectable
1wrlC-1y7iA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum)
5 / 12 MET A 149
PHE A 151
LEU A  89
GLY A  83
SER A  81
SAL  A 501 ( 4.6A)
SAL  A 501 (-4.8A)
None
None
SAL  A 501 (-3.0A)
1.15A 2ogyA-1y7iA:
undetectable
2ogyA-1y7iA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum)
5 / 9 ASP A 185
LEU A 186
SER A 115
THR A  54
THR A  59
None
1.31A 2v7uC-1y7iA:
3.1
2v7uC-1y7iA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum)
5 / 9 ASP A 185
LEU A 186
SER A 115
THR A  54
THR A  59
None
1.34A 2v7uA-1y7iA:
3.2
2v7uA-1y7iA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1300_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum)
5 / 9 ASP A 185
LEU A 186
SER A 115
THR A  54
THR A  59
None
1.32A 2v7uB-1y7iA:
2.9
2v7uB-1y7iA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum)
4 / 8 LEU A 248
LEU A 253
ALA A 256
PHE A   7
None
0.87A 2vcvF-1y7iA:
undetectable
2vcvF-1y7iA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum)
5 / 6 HIS A  80
GLN A 162
ALA A 240
ALA A 236
THR A 208
None
1.49A 2xfhA-1y7iA:
undetectable
2xfhA-1y7iA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum)
3 / 3 HIS A 238
HIS A  80
MET A 239
SAL  A 501 (-3.9A)
None
None
0.85A 3mihA-1y7iA:
undetectable
3mihA-1y7iA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum)
5 / 12 LEU A  82
ALA A 106
LEU A 119
GLY A  88
LEU A  87
SAL  A 501 (-3.9A)
None
None
None
None
1.12A 3olsA-1y7iA:
undetectable
3olsA-1y7iA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum)
5 / 11 LEU A  82
ALA A 106
LEU A 119
GLY A  88
LEU A  87
SAL  A 501 (-3.9A)
None
None
None
None
1.13A 3uudA-1y7iA:
undetectable
3uudA-1y7iA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_A_LYAA304_1
(FOLATE RECEPTOR BETA)
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum)
5 / 12 ASP A 237
TYR A 161
SER A  42
HIS A  80
GLY A  84
None
1.10A 4kn2A-1y7iA:
0.0
4kn2A-1y7iA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_A_LYAA304_1
(FOLATE RECEPTOR BETA)
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum)
5 / 12 ASP A 237
TYR A 161
SER A 179
HIS A  80
GLY A  84
None
1.49A 4kn2A-1y7iA:
0.0
4kn2A-1y7iA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_1
(FOLATE RECEPTOR BETA)
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum)
5 / 12 ASP A 237
TYR A 161
SER A  42
HIS A  80
GLY A  84
None
1.17A 4kn2C-1y7iA:
0.0
4kn2C-1y7iA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_1
(FOLATE RECEPTOR BETA)
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum)
5 / 12 ASP A 237
TYR A 161
SER A 179
HIS A  80
GLY A  84
None
1.41A 4kn2C-1y7iA:
0.0
4kn2C-1y7iA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum)
5 / 11 MET A 239
LEU A 248
LEU A   9
GLY A  16
HIS A  15
None
1.18A 4pxmB-1y7iA:
undetectable
4pxmB-1y7iA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum)
5 / 12 ILE A  49
VAL A  10
SER A  42
LEU A  89
LEU A  55
None
1.40A 4qztA-1y7iA:
undetectable
4qztA-1y7iA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum)
5 / 10 MET A 239
LEU A 248
LEU A   9
GLY A  16
HIS A  15
None
1.15A 5dx3A-1y7iA:
undetectable
5dx3A-1y7iA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum)
5 / 11 MET A 239
LEU A 248
LEU A   9
GLY A  16
HIS A  15
None
1.15A 5dxgB-1y7iA:
undetectable
5dxgB-1y7iA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum)
5 / 11 ASP A 223
VAL A 206
SER A 251
ALA A 250
VAL A 203
None
1.45A 6hu9A-1y7iA:
undetectable
6hu9E-1y7iA:
undetectable
6hu9I-1y7iA:
undetectable
6hu9A-1y7iA:
20.14
6hu9E-1y7iA:
19.78
6hu9I-1y7iA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum)
5 / 10 ASP A 223
VAL A 206
SER A 251
ALA A 250
VAL A 203
None
1.41A 6hu9L-1y7iA:
undetectable
6hu9P-1y7iA:
undetectable
6hu9T-1y7iA:
undetectable
6hu9L-1y7iA:
20.14
6hu9P-1y7iA:
19.78
6hu9T-1y7iA:
12.60