SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y7n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 1y7n AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY A MEMBER 1
(Homo
sapiens) 		5 / 12 ILE A  56
ALA A  65
GLN A  61
LEU A  75
ILE A  55
 None
 0.92A 1df7A-1y7nA:
undetectable		 1df7A-1y7nA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1y7n AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY A MEMBER 1
(Homo
sapiens) 		4 / 8 GLY A  27
GLN A  25
ILE A  35
VAL A  49
 None
 0.63A 3fi0Q-1y7nA:
undetectable		 3fi0Q-1y7nA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 1y7n AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY A MEMBER 1
(Homo
sapiens) 		5 / 12 LEU A  75
HIS A  53
ARG A  19
GLY A  48
LEU A  26
 None
 1.30A 3okxA-1y7nA:
undetectable		 3okxA-1y7nA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1y7n AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY A MEMBER 1
(Homo
sapiens) 		4 / 6 ILE A  43
PHE A  28
HIS A  83
VAL A  12
 None
 1.19A 4a97I-1y7nA:
undetectable		 4a97I-1y7nA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 1y7n AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY A MEMBER 1
(Homo
sapiens) 		4 / 7 LEU A  16
ILE A  56
ILE A  55
VAL A  63
 None
 0.47A 4ojbA-1y7nA:
undetectable		 4ojbA-1y7nA:
15.60