SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y7x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 1y7x MAJOR VAULT PROTEIN
(Homo
sapiens) 		5 / 12 LEU A  66
LEU A  36
ILE A  59
GLY A  94
ALA A  95
 None
 0.89A 1cqeA-1y7xA:
undetectable		 1cqeA-1y7xA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 1y7x MAJOR VAULT PROTEIN
(Homo
sapiens) 		5 / 12 LEU A  66
LEU A  36
ILE A  59
GLY A  94
ALA A  95
 None
 0.90A 1cqeB-1y7xA:
undetectable		 1cqeB-1y7xA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1y7x MAJOR VAULT PROTEIN
(Homo
sapiens) 		5 / 12 LEU A  66
LEU A  36
ILE A  59
GLY A  94
ALA A  95
 None
 0.93A 2aylB-1y7xA:
undetectable		 2aylB-1y7xA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1y7x MAJOR VAULT PROTEIN
(Homo
sapiens) 		5 / 12 LEU A  66
LEU A  36
ILE A  59
GLY A  94
ALA A  95
 None
 1.05A 3kk6A-1y7xA:
undetectable		 3kk6A-1y7xA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1y7x MAJOR VAULT PROTEIN
(Homo
sapiens) 		5 / 12 VAL A  90
LEU A  66
ILE A  59
GLY A  94
ALA A  95
 None
 1.13A 3kk6A-1y7xA:
undetectable		 3kk6A-1y7xA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1y7x MAJOR VAULT PROTEIN
(Homo
sapiens) 		5 / 12 LEU A  66
LEU A  36
ILE A  59
GLY A  94
ALA A  95
 None
 1.03A 3n8xB-1y7xA:
undetectable		 3n8xB-1y7xA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 1y7x MAJOR VAULT PROTEIN
(Homo
sapiens) 		4 / 7 ALA A  57
THR A  11
ALA A  12
THR A  92
 None
 1.02A 4qw0K-1y7xA:
undetectable		 4qw0K-1y7xA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 1y7x MAJOR VAULT PROTEIN
(Homo
sapiens) 		4 / 7 ALA A  57
THR A  11
ALA A  12
THR A  92
 None
 1.01A 4qw0Y-1y7xA:
undetectable		 4qw0Y-1y7xA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1y7x MAJOR VAULT PROTEIN
(Homo
sapiens) 		3 / 3 PHE A 101
ASP A  76
LEU A  89
 None
 0.76A 5uhbC-1y7xA:
undetectable		 5uhbC-1y7xA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1y7x MAJOR VAULT PROTEIN
(Homo
sapiens) 		3 / 3 PHE A 101
ASP A  76
LEU A  89
 None
 0.77A 5uhcC-1y7xA:
undetectable		 5uhcC-1y7xA:
7.75