SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y80'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 1y80 PREDICTED COBALAMIN
BINDING PROTEIN
(Moorella
thermoacetica) 		4 / 8 HIS A 101
GLY A 178
LEU A 149
ASP A  99
 B1M  A 301 (-3.6A)
B1M  A 301 (-3.2A)
B1M  A 301 (-4.3A)
B1M  A 301 (-4.2A)
 0.85A 1aegA-1y80A:
undetectable		 1aegA-1y80A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 1y80 PREDICTED COBALAMIN
BINDING PROTEIN
(Moorella
thermoacetica) 		5 / 10 THR A 159
VAL A 132
VAL A 135
VAL A 174
ILE A 160
 None
 1.25A 2qboA-1y80A:
undetectable		 2qboA-1y80A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1y80 PREDICTED COBALAMIN
BINDING PROTEIN
(Moorella
thermoacetica) 		4 / 7 ILE A 164
LEU A 163
VAL A 174
GLY A 190
 None
 0.70A 2wd9A-1y80A:
7.1		 2wd9A-1y80A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1y80 PREDICTED COBALAMIN
BINDING PROTEIN
(Moorella
thermoacetica) 		4 / 8 ILE A 164
LEU A 163
VAL A 174
GLY A 190
 None
 0.70A 2wd9B-1y80A:
6.9		 2wd9B-1y80A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1y80 PREDICTED COBALAMIN
BINDING PROTEIN
(Moorella
thermoacetica) 		5 / 12 MET A 156
ILE A 160
GLY A 177
LEU A 204
ILE A 142
 None
None
B1M  A 301 (-3.5A)
None
None
 1.10A 5m24A-1y80A:
undetectable		 5m24A-1y80A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1y80 PREDICTED COBALAMIN
BINDING PROTEIN
(Moorella
thermoacetica) 		5 / 12 LEU A 163
VAL A 174
ALA A 186
ALA A 191
GLY A 193
 None
 1.17A 5tzoB-1y80A:
undetectable		 5tzoB-1y80A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 1y80 PREDICTED COBALAMIN
BINDING PROTEIN
(Moorella
thermoacetica) 		5 / 10 SER A  87
TYR A 120
VAL A  92
GLY A 144
ALA A 186
 None
None
None
B1M  A 301 (-3.5A)
None
 1.37A 6hu9L-1y80A:
undetectable
6hu9P-1y80A:
undetectable
6hu9T-1y80A:
undetectable		 6hu9L-1y80A:
20.05
6hu9P-1y80A:
25.60
6hu9T-1y80A:
16.67