SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y88'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1y88 HYPOTHETICAL PROTEIN
AF1548
(Archaeoglobus
fulgidus) 		3 / 3 SER A  93
GLU A  94
GLU A  95
 SO4  A 301 (-2.5A)
None
None
 0.51A 1eqbD-1y88A:
undetectable		 1eqbD-1y88A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1y88 HYPOTHETICAL PROTEIN
AF1548
(Archaeoglobus
fulgidus) 		3 / 3 SER A  93
GLU A  94
GLU A  95
 SO4  A 301 (-2.5A)
None
None
 0.51A 1eqbB-1y88A:
undetectable		 1eqbB-1y88A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1y88 HYPOTHETICAL PROTEIN
AF1548
(Archaeoglobus
fulgidus) 		4 / 6 ASP A 153
LEU A 148
GLY A 147
ARG A  13
 None
 0.84A 1mt1G-1y88A:
undetectable
1mt1J-1y88A:
undetectable		 1mt1G-1y88A:
15.58
1mt1J-1y88A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1y88 HYPOTHETICAL PROTEIN
AF1548
(Archaeoglobus
fulgidus) 		4 / 7 ARG A  13
ASP A 153
LEU A 148
GLY A 147
 None
 0.87A 1mt1H-1y88A:
undetectable
1mt1K-1y88A:
undetectable		 1mt1H-1y88A:
19.49
1mt1K-1y88A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1y88 HYPOTHETICAL PROTEIN
AF1548
(Archaeoglobus
fulgidus) 		4 / 7 ARG A  13
ASP A 153
LEU A 148
GLY A 147
 None
 0.88A 1n13D-1y88A:
undetectable
1n13E-1y88A:
undetectable		 1n13D-1y88A:
19.49
1n13E-1y88A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1y88 HYPOTHETICAL PROTEIN
AF1548
(Archaeoglobus
fulgidus) 		4 / 8 ASP A 153
LEU A 148
GLY A 147
ARG A  13
 None
 0.87A 1n13A-1y88A:
undetectable
1n13F-1y88A:
undetectable		 1n13A-1y88A:
15.58
1n13F-1y88A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1y88 HYPOTHETICAL PROTEIN
AF1548
(Archaeoglobus
fulgidus) 		4 / 6 ARG A  13
ASP A 153
LEU A 148
GLY A 147
 None
 0.89A 1n13H-1y88A:
undetectable
1n13K-1y88A:
undetectable		 1n13H-1y88A:
19.49
1n13K-1y88A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1y88 HYPOTHETICAL PROTEIN
AF1548
(Archaeoglobus
fulgidus) 		4 / 7 ASP A 153
LEU A 148
GLY A 147
ARG A  13
 None
 0.88A 1n13G-1y88A:
undetectable
1n13J-1y88A:
undetectable		 1n13G-1y88A:
15.58
1n13J-1y88A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1y88 HYPOTHETICAL PROTEIN
AF1548
(Archaeoglobus
fulgidus) 		4 / 8 ARG A  13
ASP A 153
LEU A 148
GLY A 147
 None
 0.90A 2qqcH-1y88A:
undetectable
2qqcK-1y88A:
undetectable		 2qqcH-1y88A:
20.30
2qqcK-1y88A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_2
(DIHYDROFOLATE
REDUCTASE)		 1y88 HYPOTHETICAL PROTEIN
AF1548
(Archaeoglobus
fulgidus) 		4 / 4 PHE A  54
LYS A   3
ILE A 118
THR A  61
 None
 1.37A 3ia4B-1y88A:
undetectable		 3ia4B-1y88A:
18.72