SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y8a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 1y8a HYPOTHETICAL PROTEIN
AF1437
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 114
HIS A 124
LEU A 123
THR A   4
PHE A   2
 None
 1.05A 1bzfA-1y8aA:
2.2		 1bzfA-1y8aA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 1y8a HYPOTHETICAL PROTEIN
AF1437
(Archaeoglobus
fulgidus) 		3 / 3 TRP A   6
ARG A  74
THR A  13
 None
 1.01A 1df7A-1y8aA:
undetectable		 1df7A-1y8aA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1y8a HYPOTHETICAL PROTEIN
AF1437
(Archaeoglobus
fulgidus) 		4 / 7 PHE A   2
GLN A  94
VAL A 119
TRP A   6
 None
 1.37A 1jqdA-1y8aA:
1.7		 1jqdA-1y8aA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 1y8a HYPOTHETICAL PROTEIN
AF1437
(Archaeoglobus
fulgidus) 		4 / 6 TYR A  53
TYR A  49
GLU A 185
VAL A 178
 None
 1.25A 1q13A-1y8aA:
undetectable		 1q13A-1y8aA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 1y8a HYPOTHETICAL PROTEIN
AF1437
(Archaeoglobus
fulgidus) 		4 / 8 SER A 293
VAL A 289
VAL A 241
LEU A 290
 None
 0.84A 2ddwA-1y8aA:
undetectable		 2ddwA-1y8aA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPW_A_OTCA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1y8a HYPOTHETICAL PROTEIN
AF1437
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  93
PRO A   9
VAL A 205
ILE A 242
SER A 249
 None
 1.47A 2xpwA-1y8aA:
undetectable		 2xpwA-1y8aA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 1y8a HYPOTHETICAL PROTEIN
AF1437
(Archaeoglobus
fulgidus) 		4 / 6 ILE A 226
GLU A 250
ILE A 254
ASP A   5
 None
None
None
MG  A 501 (-2.7A)
 0.97A 3a7eA-1y8aA:
3.3		 3a7eA-1y8aA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1y8a HYPOTHETICAL PROTEIN
AF1437
(Archaeoglobus
fulgidus) 		4 / 7 GLY A 182
GLU A 185
GLU A  47
ALA A  41
 None
 0.85A 3fpjB-1y8aA:
2.1		 3fpjB-1y8aA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HTH_B_PRLB201_0
(EBRA REPRESSOR)		 1y8a HYPOTHETICAL PROTEIN
AF1437
(Archaeoglobus
fulgidus) 		5 / 9 VAL A 171
LEU A 162
TYR A  49
LEU A  33
ASP A  37
 None
 1.03A 3hthB-1y8aA:
0.0		 3hthB-1y8aA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 1y8a HYPOTHETICAL PROTEIN
AF1437
(Archaeoglobus
fulgidus) 		5 / 12 SER A 208
ARG A 301
GLY A 182
ALA A  51
GLY A 309
 MG  A 501 ( 4.1A)
MG  A 501 ( 4.7A)
None
None
None
 1.09A 3tegA-1y8aA:
undetectable		 3tegA-1y8aA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 1y8a HYPOTHETICAL PROTEIN
AF1437
(Archaeoglobus
fulgidus) 		5 / 10 ASP A  71
VAL A  23
GLY A  66
ALA A  65
ALA A  64
 None
 1.08A 3ucjA-1y8aA:
undetectable		 3ucjA-1y8aA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 1y8a HYPOTHETICAL PROTEIN
AF1437
(Archaeoglobus
fulgidus) 		5 / 10 ASP A  71
VAL A  23
GLY A  66
ALA A  65
ALA A  64
 None
 1.05A 3ucjB-1y8aA:
undetectable		 3ucjB-1y8aA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 1y8a HYPOTHETICAL PROTEIN
AF1437
(Archaeoglobus
fulgidus) 		4 / 6 ASP A   5
ASP A 211
TYR A 233
ASP A 207
 MG  A 501 (-2.7A)
MG  A 501 ( 4.6A)
None
MG  A 501 (-2.6A)
 1.09A 4mdaA-1y8aA:
undetectable		 4mdaA-1y8aA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 1y8a HYPOTHETICAL PROTEIN
AF1437
(Archaeoglobus
fulgidus) 		4 / 6 ASP A   5
ASP A 211
TYR A 233
ASP A 207
 MG  A 501 (-2.7A)
MG  A 501 ( 4.6A)
None
MG  A 501 (-2.6A)
 1.11A 4mdbA-1y8aA:
undetectable		 4mdbA-1y8aA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1y8a HYPOTHETICAL PROTEIN
AF1437
(Archaeoglobus
fulgidus) 		5 / 12 TYR A 193
GLY A 121
MET A   1
HIS A 124
LEU A 110
 None
 1.02A 4mwzA-1y8aA:
undetectable		 4mwzA-1y8aA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1y8a HYPOTHETICAL PROTEIN
AF1437
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  58
ASP A  37
THR A 126
TYR A 106
ASP A  14
 None
 1.11A 4ng6A-1y8aA:
undetectable		 4ng6A-1y8aA:
27.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 1y8a HYPOTHETICAL PROTEIN
AF1437
(Archaeoglobus
fulgidus) 		5 / 11 ASN A 231
ILE A 209
SER A 210
GLY A  52
ASP A  38
 None
 1.21A 4xt7A-1y8aA:
1.1		 4xt7A-1y8aA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 1y8a HYPOTHETICAL PROTEIN
AF1437
(Archaeoglobus
fulgidus) 		5 / 12 ASN A 231
ILE A 209
SER A 210
GLY A  52
ARG A 301
 None
None
None
None
MG  A 501 ( 4.7A)
 1.27A 4xt8A-1y8aA:
2.1		 4xt8A-1y8aA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 1y8a HYPOTHETICAL PROTEIN
AF1437
(Archaeoglobus
fulgidus) 		5 / 12 ASN A 231
ILE A 209
SER A 210
GLY A  52
ASP A  38
 None
 1.23A 4xt8A-1y8aA:
2.1		 4xt8A-1y8aA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1y8a HYPOTHETICAL PROTEIN
AF1437
(Archaeoglobus
fulgidus) 		4 / 7 ASP A 239
ARG A 219
GLY A 220
GLU A 216
 None
 1.07A 5btfA-1y8aA:
undetectable
5btfC-1y8aA:
undetectable
5btfD-1y8aA:
undetectable		 5btfA-1y8aA:
24.44
5btfC-1y8aA:
24.44
5btfD-1y8aA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1y8a HYPOTHETICAL PROTEIN
AF1437
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  58
ASP A  37
THR A 126
TYR A 106
ASP A  14
 None
 1.22A 5cg5A-1y8aA:
undetectable		 5cg5A-1y8aA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		 1y8a HYPOTHETICAL PROTEIN
AF1437
(Archaeoglobus
fulgidus) 		4 / 5 GLY A   8
ASP A 207
ARG A 297
MET A  21
 MG  A 501 ( 4.4A)
MG  A 501 (-2.6A)
None
None
 1.39A 5gwkA-1y8aA:
undetectable		 5gwkA-1y8aA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1y8a HYPOTHETICAL PROTEIN
AF1437
(Archaeoglobus
fulgidus) 		4 / 6 THR A   4
LEU A  12
LEU A  17
GLU A 306
 None
 0.95A 5tudD-1y8aA:
undetectable		 5tudD-1y8aA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1y8a HYPOTHETICAL PROTEIN
AF1437
(Archaeoglobus
fulgidus) 		4 / 6 ASP A 207
ASP A   5
ARG A 301
LYS A 186
 MG  A 501 (-2.6A)
MG  A 501 (-2.7A)
MG  A 501 ( 4.7A)
None
 1.35A 6g31L-1y8aA:
undetectable		 6g31L-1y8aA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 1y8a HYPOTHETICAL PROTEIN
AF1437
(Archaeoglobus
fulgidus) 		3 / 3 ASP A 163
ASP A  37
ASN A 231
 None
 0.79A 6gngB-1y8aA:
2.1		 6gngB-1y8aA:
22.08