SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y8c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 7 LEU A  56
SER A  25
ASP A  26
PHE A  39
 None
 1.25A 1ismB-1y8cA:
undetectable		 1ismB-1y8cA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 11 PHE A  27
ILE A 140
ASP A  44
LEU A  52
ALA A  46
 None
 1.43A 1ju6D-1y8cA:
undetectable		 1ju6D-1y8cA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI3_B_PE2B2_1
(THYMIDINE KINASE)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 HIS A 199
ILE A 182
ILE A  15
TYR A  11
GLU A 197
 None
 1.41A 1ki3B-1y8cA:
0.0		 1ki3B-1y8cA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 GLY A  48
THR A  49
SER A  69
MET A  72
SER A 112
 None
 0.78A 1nbiC-1y8cA:
22.5		 1nbiC-1y8cA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 GLY A  48
THR A  49
SER A  69
MET A  72
SER A 112
 None
 0.77A 1nbiD-1y8cA:
22.6		 1nbiD-1y8cA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 5 ASP A  67
LEU A  97
ALA A  90
LEU A  73
 None
 1.14A 1nh8A-1y8cA:
undetectable		 1nh8A-1y8cA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 10 LEU A  56
ASP A  40
ASP A  41
GLY A 137
THR A 107
 None
 1.01A 1t7iA-1y8cA:
undetectable		 1t7iA-1y8cA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		3 / 3 LYS A  31
ASP A 225
ASN A 229
 None
 1.14A 2bm9A-1y8cA:
10.8		 2bm9A-1y8cA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 7 GLY A  48
TYR A  21
ASP A  67
ASP A  93
 None
 1.08A 2g72B-1y8cA:
15.7		 2g72B-1y8cA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 7 ASP A 225
THR A 240
ILE A 143
ASN A 114
 None
 1.04A 2jc9A-1y8cA:
2.1		 2jc9A-1y8cA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KI5_A_AC2A1_1
(PROTEIN (THYMIDINE
KINASE))		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 HIS A 199
ILE A 182
ILE A  15
TYR A  11
GLU A 197
 None
 1.43A 2ki5A-1y8cA:
0.0		 2ki5A-1y8cA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 7 ALA A  46
GLY A  48
ASP A  67
ASP A  93
 None
 0.56A 2uyqA-1y8cA:
11.6		 2uyqA-1y8cA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 6 ASP A  93
LEU A  97
ASP A  67
LEU A  73
 None
 1.25A 3bj8C-1y8cA:
undetectable
3bj8D-1y8cA:
undetectable		 3bj8C-1y8cA:
20.54
3bj8D-1y8cA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		7 / 12 ALA A  46
GLY A  48
LEU A  68
SER A  69
MET A  72
SER A 112
TYR A 115
 None
 0.50A 3bxoA-1y8cA:
26.4		 3bxoA-1y8cA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		7 / 12 ALA A  46
GLY A  48
LEU A  68
SER A  69
MET A  72
SER A 112
TYR A 115
 None
 0.55A 3bxoB-1y8cA:
26.2		 3bxoB-1y8cA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		3 / 3 CYH A 108
PHE A 141
PHE A 139
 None
 0.75A 3cr5X-1y8cA:
undetectable		 3cr5X-1y8cA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		6 / 12 ALA A  46
GLY A  48
LEU A  52
LEU A  68
SER A  69
SER A 112
 None
 0.71A 3g2oA-1y8cA:
19.4		 3g2oA-1y8cA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		6 / 12 ALA A  46
GLY A  48
LEU A  52
LEU A  68
ASP A  93
SER A 112
 None
 0.69A 3g2oB-1y8cA:
20.2		 3g2oB-1y8cA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 9 LEU A  56
ASP A  40
ASP A  41
GLY A 137
THR A 107
 None
 1.03A 3gguB-1y8cA:
undetectable		 3gguB-1y8cA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_D_ACTD229_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 4 ASP A 104
GLY A 136
LYS A 134
GLU A 135
 None
 1.41A 3hznD-1y8cA:
undetectable		 3hznD-1y8cA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_D_ACTD229_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 4 ASP A 104
GLY A 137
LYS A 134
GLU A 135
 None
 1.42A 3hznD-1y8cA:
undetectable		 3hznD-1y8cA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 ALA A  46
GLY A  48
SER A  69
MET A  72
ASP A  93
 None
 0.64A 3ou6A-1y8cA:
18.2		 3ou6A-1y8cA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 ALA A  46
GLY A  48
SER A  69
MET A  72
ASP A  93
 None
 0.62A 3ou7A-1y8cA:
18.2		 3ou7A-1y8cA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		3 / 3 GLY A  48
ASP A  67
ASP A  93
 None
 0.24A 3ou7C-1y8cA:
18.3		 3ou7C-1y8cA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 ALA A  46
GLY A  48
SER A  69
MET A  72
ASP A  93
 None
 0.61A 3ou7D-1y8cA:
18.3		 3ou7D-1y8cA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		7 / 12 ALA A  46
GLY A  48
LEU A  68
SER A  69
MET A  72
ASP A  93
SER A 112
 None
 0.58A 3pfgA-1y8cA:
26.2		 3pfgA-1y8cA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 LEU A  56
ASP A  40
ASP A  41
GLY A 137
THR A 107
 None
 1.05A 3spkB-1y8cA:
undetectable		 3spkB-1y8cA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 GLY A  48
VAL A  66
LEU A  68
SER A 112
TYR A 115
 None
 1.03A 4f84A-1y8cA:
16.6		 4f84A-1y8cA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 8 ASP A  67
ASP A  44
ASP A  12
ARG A  16
 None
 1.14A 4gkhF-1y8cA:
2.2		 4gkhF-1y8cA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 TYR A  21
ASP A  67
LEU A  68
SER A  69
ILE A  94
 None
 0.86A 5dpdB-1y8cA:
18.1		 5dpdB-1y8cA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 4 ASP A  44
GLY A  48
ASP A  67
ASP A  93
 None
 0.65A 5e72A-1y8cA:
16.8		 5e72A-1y8cA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		3 / 3 THR A  49
ALA A   8
ASN A  51
 None
 0.61A 5ersA-1y8cA:
undetectable		 5ersA-1y8cA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 ALA A  46
GLY A  48
SER A  69
MET A  72
SER A 112
 None
 0.43A 5gwxA-1y8cA:
21.6		 5gwxA-1y8cA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 GLY A  48
SER A  69
MET A  72
ASP A  93
SER A 112
 None
 0.93A 5hikA-1y8cA:
21.5		 5hikA-1y8cA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 11 PHE A  27
ILE A 140
ASP A  44
LEU A  52
ALA A  46
 None
 1.28A 6r2eF-1y8cA:
undetectable		 6r2eF-1y8cA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 PHE A  27
ILE A 140
ASP A  44
LEU A  52
ALA A  46
 None
 1.29A 6r2eH-1y8cA:
0.0		 6r2eH-1y8cA:
18.95