SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y8p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3
(Homo
sapiens) 		4 / 7 LEU A 281
THR A 272
LEU A 276
VAL A 220
 None
 0.42A 1ictD-1y8pA:
undetectable		 1ictD-1y8pA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3
(Homo
sapiens) 		4 / 8 LEU A 281
THR A 272
LEU A 276
VAL A 220
 None
 0.68A 1sn5C-1y8pA:
0.6		 1sn5C-1y8pA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3
(Homo
sapiens) 		4 / 7 PHE A 150
LEU A  72
VAL A  77
GLY A  78
 None
 0.78A 1t88A-1y8pA:
undetectable		 1t88A-1y8pA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3
(Homo
sapiens) 		4 / 7 LEU A 281
THR A 272
LEU A 276
VAL A 220
 None
 0.51A 1tyrB-1y8pA:
undetectable		 1tyrB-1y8pA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3
(Homo
sapiens) 		3 / 3 ARG A 336
ARG A 368
ILE A 159
 None
 0.81A 1uobA-1y8pA:
undetectable		 1uobA-1y8pA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1y8p DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
COMPONENT OF
PYRUVATE
DEHYDROGENASE
COMPLEX
(Homo
sapiens) 		5 / 12 LEU B 140
THR B 171
LEU B 200
GLY B 201
PHE B 178
 None
 1.43A 1v8bB-1y8pB:
undetectable		 1v8bB-1y8pB:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3
DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
COMPONENT OF
PYRUVATE
DEHYDROGENASE
COMPLEX
(Homo
sapiens;
Homo
sapiens) 		3 / 3 GLY B 177
GLU B 168
ASN A 373
 None
 0.68A 1zq9A-1y8pB:
undetectable		 1zq9A-1y8pB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3
(Homo
sapiens) 		4 / 8 PHE A 150
LEU A  72
VAL A  77
GLY A  78
 None
 0.83A 2a1oA-1y8pA:
undetectable		 2a1oA-1y8pA:
23.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3
(Homo
sapiens) 		4 / 8 LEU A  57
TYR A  84
HIS A 119
ILE A 165
 None
 0.73A 2bu8A-1y8pA:
47.7		 2bu8A-1y8pA:
64.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 1y8p DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
COMPONENT OF
PYRUVATE
DEHYDROGENASE
COMPLEX
(Homo
sapiens) 		4 / 5 LEU B 200
LEU B 137
LEU B 166
MET B 144
 None
 0.90A 2oaxF-1y8pB:
undetectable		 2oaxF-1y8pB:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3
(Homo
sapiens) 		3 / 3 MET A  47
VAL A 104
GLU A  95
 None
 0.69A 3c6gA-1y8pA:
undetectable		 3c6gA-1y8pA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3
(Homo
sapiens) 		5 / 12 VAL A 292
GLY A 291
GLY A 349
THR A 352
LEU A 344
 ATP  A 504 (-4.9A)
ATP  A 504 ( 4.7A)
None
ATP  A 504 (-4.1A)
None
 1.31A 3dh0A-1y8pA:
undetectable		 3dh0A-1y8pA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1y8p DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
COMPONENT OF
PYRUVATE
DEHYDROGENASE
COMPLEX
(Homo
sapiens) 		4 / 6 GLY B 147
THR B 202
GLU B 170
GLU B 153
 None
 1.08A 3fpjA-1y8pB:
undetectable		 3fpjA-1y8pB:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3
DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
COMPONENT OF
PYRUVATE
DEHYDROGENASE
COMPLEX
(Homo
sapiens;
Homo
sapiens) 		4 / 5 ASN A 157
GLU B 168
THR B 175
SER A 160
 None
 1.38A 3p2kC-1y8pA:
undetectable		 3p2kC-1y8pA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3
(Homo
sapiens) 		4 / 7 LEU A 281
LEU A 276
PRO A 231
ILE A 232
 None
 0.89A 3s56B-1y8pA:
undetectable		 3s56B-1y8pA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3
(Homo
sapiens) 		5 / 12 LYS A 250
ASN A 251
THR A 352
ALA A 354
ILE A 356
 ATP  A 504 (-3.4A)
ATP  A 504 ( 2.7A)
ATP  A 504 (-4.1A)
None
None
 1.18A 3ut5B-1y8pA:
undetectable		 3ut5B-1y8pA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3
(Homo
sapiens) 		4 / 7 GLU A 258
TYR A 260
ARG A 263
GLY A 290
 None
 0.82A 4fgzA-1y8pA:
undetectable		 4fgzA-1y8pA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3
(Homo
sapiens) 		4 / 7 GLU A 261
TYR A 260
ARG A 263
GLY A 290
 None
 1.05A 4fgzA-1y8pA:
undetectable		 4fgzA-1y8pA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3
(Homo
sapiens) 		4 / 8 GLU A 258
TYR A 260
ARG A 263
GLY A 290
 None
 1.00A 4fgzA-1y8pA:
undetectable
4fgzB-1y8pA:
undetectable		 4fgzA-1y8pA:
20.48
4fgzB-1y8pA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3
(Homo
sapiens) 		4 / 8 GLU A 261
TYR A 260
ARG A 263
GLY A 290
 None
 1.06A 4fgzA-1y8pA:
undetectable
4fgzB-1y8pA:
undetectable		 4fgzA-1y8pA:
20.48
4fgzB-1y8pA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3
(Homo
sapiens) 		4 / 8 LEU A 281
THR A 272
LEU A 276
VAL A 220
 None
 0.81A 4iizB-1y8pA:
undetectable		 4iizB-1y8pA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3
(Homo
sapiens) 		4 / 8 LEU A 281
THR A 272
LEU A 276
VAL A 220
 None
 0.64A 4ik7B-1y8pA:
undetectable		 4ik7B-1y8pA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3
(Homo
sapiens) 		4 / 7 ASN A 166
LEU A 109
LEU A  49
ILE A 113
 None
 1.05A 4okwA-1y8pA:
undetectable		 4okwA-1y8pA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3
DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
COMPONENT OF
PYRUVATE
DEHYDROGENASE
COMPLEX
(Homo
sapiens;
Homo
sapiens) 		3 / 3 SER A 160
GLU A  63
GLU B 179
 None
 0.63A 4ymgB-1y8pA:
undetectable		 4ymgB-1y8pA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3
(Homo
sapiens) 		3 / 3 LYS A 182
LEU A 171
ILE A 187
 None
 0.75A 5kc0A-1y8pA:
1.9		 5kc0A-1y8pA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3
(Homo
sapiens) 		4 / 8 LEU A  72
LEU A  66
THR A  60
MET A 126
 None
 1.02A 5ljbA-1y8pA:
undetectable		 5ljbA-1y8pA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHG_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3
(Homo
sapiens) 		4 / 4 ARG A  56
GLN A 167
PHE A 161
LEU A 170
 None
 1.48A 5uhgC-1y8pA:
0.0		 5uhgC-1y8pA:
15.81