SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y8q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B
(Homo
sapiens) 		4 / 8 ILE B 365
PHE B 366
THR B 268
LEU B 267
 None
 0.92A 1v55N-1y8qB:
2.8
1v55W-1y8qB:
undetectable		 1v55N-1y8qB:
21.77
1v55W-1y8qB:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B
(Homo
sapiens) 		5 / 10 ARG B 122
ASP B  48
GLY B  29
GLY B  26
ILE B  96
 None
ATP  B 802 (-2.9A)
None
ATP  B 802 (-3.5A)
ATP  B 802 (-4.2A)
 1.00A 1x7pA-1y8qB:
3.2
1x7pB-1y8qB:
3.9		 1x7pA-1y8qB:
18.60
1x7pB-1y8qB:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B
(Homo
sapiens) 		4 / 8 ALA B 319
PHE B 322
ALA B 358
ARG B 362
 None
 0.85A 2bxmA-1y8qB:
undetectable		 2bxmA-1y8qB:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B
(Homo
sapiens) 		4 / 8 LEU B 111
ILE B  44
GLY B  29
ILE B  28
 None
 0.71A 2o4nB-1y8qB:
undetectable		 2o4nB-1y8qB:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B
(Homo
sapiens) 		5 / 12 LEU B 517
ASP B 520
THR B 488
GLY B 487
GLY B 485
 None
 1.21A 2uvnA-1y8qB:
undetectable		 2uvnA-1y8qB:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B
(Homo
sapiens) 		4 / 7 LEU B 192
LEU B 196
PHE B 354
PRO B 251
 None
 1.00A 2vq5B-1y8qB:
undetectable		 2vq5B-1y8qB:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B
(Homo
sapiens) 		5 / 10 VAL B  20
ILE B  44
LEU B  33
GLY B  29
ALA B 115
 None
 1.17A 2xf3A-1y8qB:
undetectable		 2xf3A-1y8qB:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B
(Homo
sapiens) 		4 / 8 GLN B 524
GLN B 465
ASP B 479
SER B 493
 None
 1.25A 2xz5C-1y8qB:
undetectable
2xz5D-1y8qB:
undetectable		 2xz5C-1y8qB:
15.16
2xz5D-1y8qB:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B
(Homo
sapiens) 		4 / 8 ILE B 365
PHE B 366
THR B 268
LEU B 267
 None
 0.92A 3abkA-1y8qB:
2.9
3abkJ-1y8qB:
undetectable		 3abkA-1y8qB:
21.77
3abkJ-1y8qB:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B
(Homo
sapiens) 		4 / 8 ILE B 365
PHE B 366
THR B 268
LEU B 267
 None
 0.90A 3abmN-1y8qB:
3.2
3abmW-1y8qB:
undetectable		 3abmN-1y8qB:
21.77
3abmW-1y8qB:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B
(Homo
sapiens) 		5 / 12 LEU B  38
GLY B  40
VAL B  15
LEU B  32
ILE B  44
 None
 1.43A 3h52A-1y8qB:
undetectable		 3h52A-1y8qB:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B
(Homo
sapiens) 		4 / 7 TYR B 265
GLU B 218
LEU B 266
ASN B 177
 None
 1.34A 3k8mA-1y8qB:
3.0		 3k8mA-1y8qB:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B
(Homo
sapiens) 		4 / 7 TYR B 265
GLU B 218
LEU B 266
ASN B 177
 None
 1.20A 3k8mB-1y8qB:
undetectable		 3k8mB-1y8qB:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B
(Homo
sapiens) 		5 / 8 LEU B 506
VAL B 469
ILE B 491
VAL B 480
LEU B 517
 None
 1.23A 3kp6A-1y8qB:
undetectable
3kp6B-1y8qB:
undetectable		 3kp6A-1y8qB:
14.01
3kp6B-1y8qB:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B
(Homo
sapiens) 		4 / 7 GLU B 214
ASP B 212
THR B 174
ALA B 173
 None
 1.09A 3mbgA-1y8qB:
undetectable
3mbgB-1y8qB:
2.2		 3mbgA-1y8qB:
11.88
3mbgB-1y8qB:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B
(Homo
sapiens) 		5 / 10 ILE B 326
ASN B 360
ALA B 358
LEU B 196
LEU B 192
 None
 1.12A 3o02A-1y8qB:
undetectable
3o02B-1y8qB:
undetectable		 3o02A-1y8qB:
19.01
3o02B-1y8qB:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B
(Homo
sapiens) 		5 / 12 LEU B 111
ILE B  44
GLY B  29
ILE B  28
VAL B  20
 None
 0.86A 3ucbB-1y8qB:
undetectable		 3ucbB-1y8qB:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B
(Homo
sapiens) 		4 / 6 MET B 269
LEU B 272
PRO B 179
PRO B 279
 None
 1.13A 3vkxA-1y8qB:
undetectable		 3vkxA-1y8qB:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B
(Homo
sapiens) 		6 / 12 ILE B 398
LEU B  21
LEU B  32
ALA B 115
ILE B 405
LEU B 136
 None
 1.40A 3vrmA-1y8qB:
undetectable		 3vrmA-1y8qB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B
(Homo
sapiens) 		4 / 7 ILE B 326
LEU B 329
PHE B 193
GLY B 198
 None
 1.06A 4hbfA-1y8qB:
undetectable		 4hbfA-1y8qB:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B
(Homo
sapiens) 		5 / 11 SER B 323
ALA B 358
GLU B 327
THR B 247
GLY B 248
 None
 1.28A 4zjoD-1y8qB:
2.5		 4zjoD-1y8qB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B
(Homo
sapiens) 		4 / 7 ILE B 365
PHE B 366
THR B 268
LEU B 267
 None
 0.90A 5b1bN-1y8qB:
2.9
5b1bW-1y8qB:
undetectable		 5b1bN-1y8qB:
21.77
5b1bW-1y8qB:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B
(Homo
sapiens) 		5 / 12 GLY B  24
ASP B  48
ILE B  96
LEU B  32
LEU B 116
 ATP  B 802 ( 3.9A)
ATP  B 802 (-2.9A)
ATP  B 802 (-4.2A)
None
ATP  B 802 (-4.5A)
 0.98A 5bw4A-1y8qB:
5.5		 5bw4A-1y8qB:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B
(Homo
sapiens) 		5 / 12 GLY B  24
ASP B  48
LEU B  49
SER B  95
ILE B  96
 ATP  B 802 ( 3.9A)
ATP  B 802 (-2.9A)
ATP  B 802 (-4.3A)
ATP  B 802 (-3.2A)
ATP  B 802 (-4.2A)
 0.96A 5dpdB-1y8qB:
6.9		 5dpdB-1y8qB:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B
(Homo
sapiens) 		4 / 6 ARG B  59
ASP B 347
ASP B  53
LYS B 346
 ATP  B 802 (-4.1A)
ATP  B 802 ( 4.3A)
None
ATP  B 802 (-2.9A)
 1.22A 5hp1C-1y8qB:
0.8		 5hp1C-1y8qB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B
(Homo
sapiens) 		4 / 8 ILE B 365
PHE B 366
THR B 268
LEU B 267
 None
 0.90A 5zcpN-1y8qB:
2.3
5zcpW-1y8qB:
undetectable		 5zcpN-1y8qB:
21.77
5zcpW-1y8qB:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B
(Homo
sapiens) 		4 / 8 LEU B 506
VAL B 480
LEU B 490
ILE B 491
 None
 0.90A 6cb4A-1y8qB:
undetectable		 6cb4A-1y8qB:
22.27