SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y8t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 183
GLY A 182
LEU A 180
GLY A 170
SER A  18
 None
 0.82A 1fduC-1y8tA:
undetectable		 1fduC-1y8tA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 180
ALA A 207
ILE A 208
GLY A 170
 None
 0.82A 1sv9A-1y8tA:
undetectable		 1sv9A-1y8tA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 217
LEU A  38
ILE A  37
ILE A  44
LEU A 105
 None
 1.24A 1xdkB-1y8tA:
undetectable		 1xdkB-1y8tA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		5 / 11 ILE A 216
VAL A  91
GLY A  82
LEU A  45
SER A 185
 None
 1.38A 2bxeA-1y8tA:
undetectable		 2bxeA-1y8tA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 158
GLY A 182
LEU A 180
LEU A 105
 None
 0.81A 2vctA-1y8tA:
undetectable		 2vctA-1y8tA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 158
GLY A 182
LEU A 180
LEU A 105
 None
 0.83A 2vctC-1y8tA:
undetectable		 2vctC-1y8tA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  90
ILE A  51
LEU A  22
VAL A  20
ILE A  37
 None
 0.80A 3adsB-1y8tA:
undetectable		 3adsB-1y8tA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  90
ILE A  51
LEU A  22
VAL A  20
ILE A  37
 None
 0.82A 3adxB-1y8tA:
undetectable		 3adxB-1y8tA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		5 / 12 HIS A  49
ASP A  88
GLY A 167
SER A 169
ALA A 186
 None
 0.81A 3keeB-1y8tA:
14.4		 3keeB-1y8tA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		5 / 12 HIS A  49
ASP A  88
GLY A 167
SER A 169
ALA A 186
 None
 0.81A 3keeC-1y8tA:
13.6		 3keeC-1y8tA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		5 / 12 HIS A  49
ASP A  88
GLY A 167
SER A 169
ALA A 186
 None
 0.82A 3keeD-1y8tA:
13.9		 3keeD-1y8tA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 182
GLY A  35
GLY A 170
VAL A  68
ILE A  44
 None
 0.89A 3p97A-1y8tA:
undetectable		 3p97A-1y8tA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		5 / 12 HIS A  49
ASP A  88
GLY A 167
SER A 169
ALA A 186
 None
 0.83A 3sueA-1y8tA:
12.7		 3sueA-1y8tA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		5 / 12 HIS A  49
ASP A  88
GLY A 167
SER A 169
ALA A 186
 None
 0.83A 3sueC-1y8tA:
6.6		 3sueC-1y8tA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		5 / 11 HIS A  49
ASP A  88
GLY A 167
SER A 169
ALA A 186
 None
 0.85A 3sufC-1y8tA:
12.4		 3sufC-1y8tA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_1
(POL POLYPROTEIN)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 295
GLY A 259
ALA A 258
GLY A 252
VAL A 309
 None
 0.93A 3u7sA-1y8tA:
undetectable		 3u7sA-1y8tA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		5 / 8 GLY A  33
GLY A 167
SER A  34
GLY A 171
VAL A  19
 None
 1.21A 3v1nA-1y8tA:
undetectable		 3v1nA-1y8tA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 216
VAL A  19
ILE A  51
LEU A  22
VAL A  20
 None
 0.98A 3w68B-1y8tA:
undetectable		 3w68B-1y8tA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 216
VAL A  19
ILE A  51
LEU A  22
VAL A  20
 None
 1.08A 3w68C-1y8tA:
undetectable		 3w68C-1y8tA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 182
GLY A  35
GLY A 170
VAL A  68
ILE A  44
 None
 0.89A 4ctkA-1y8tA:
undetectable		 4ctkA-1y8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		6 / 11 ALA A 163
GLY A 167
GLY A 121
ILE A 164
GLU A  23
ASN A 165
 None
 1.11A 4dcmA-1y8tA:
undetectable		 4dcmA-1y8tA:
26.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 119
SER A 108
GLY A 182
ALA A 207
VAL A 135
 None
 1.23A 4r1zA-1y8tA:
undetectable		 4r1zA-1y8tA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RUJ_A_VDXA501_1
(VITAMIN D3 RECEPTOR
A)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 183
SER A 185
ILE A 208
SER A  87
VAL A  91
 None
 1.47A 4rujA-1y8tA:
0.1		 4rujA-1y8tA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 182
GLY A  35
GLY A 170
VAL A  68
ILE A  44
 None
 0.88A 5e9qA-1y8tA:
undetectable		 5e9qA-1y8tA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 182
GLY A  35
GLY A 170
VAL A  68
ILE A  44
 None
 0.86A 5ec8A-1y8tA:
undetectable		 5ec8A-1y8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 182
GLY A  35
GLY A 170
VAL A  68
ILE A  44
 None
 0.87A 5ehgA-1y8tA:
undetectable		 5ehgA-1y8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		5 / 8 VAL A  15
ILE A 120
ALA A 119
VAL A   8
VAL A  11
 None
 1.16A 5l94A-1y8tA:
undetectable		 5l94A-1y8tA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 182
GLY A  35
GLY A 170
VAL A  68
ILE A  44
 None
 0.86A 5njvC-1y8tA:
undetectable		 5njvC-1y8tA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 182
GLY A  35
GLY A 170
VAL A  68
ILE A  44
 None
 0.92A 5vimB-1y8tA:
undetectable		 5vimB-1y8tA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 182
GLY A  35
GLY A 170
VAL A  68
ILE A  44
 None
 0.91A 5wz2A-1y8tA:
undetectable		 5wz2A-1y8tA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 182
GLY A  35
GLY A 170
VAL A  68
ILE A  44
 None
 0.88A 5wz2B-1y8tA:
undetectable		 5wz2B-1y8tA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 182
GLY A  35
GLY A 170
VAL A  68
ILE A  44
 None
 0.90A 5wz2C-1y8tA:
undetectable		 5wz2C-1y8tA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		4 / 5 HIS A  49
ALA A 186
SER A 169
GLY A 170
 None
 1.08A 5yodB-1y8tA:
6.1		 5yodB-1y8tA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 1y8t HYPOTHETICAL PROTEIN
RV0983
(Mycobacterium
tuberculosis) 		5 / 12 HIS A  49
ASP A  88
GLY A 167
SER A 169
ALA A 186
 None
 0.79A 6c2mC-1y8tA:
12.6		 6c2mC-1y8tA:
14.10