SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y8x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1y8x UBIQUITIN-CONJUGATIN
G ENZYME E2 M
(Homo
sapiens) 		3 / 3 ILE A 114
LEU A 115
VAL A 110
 None
 0.24A 1mz9B-1y8xA:
undetectable		 1mz9B-1y8xA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1y8x UBIQUITIN-CONJUGATIN
G ENZYME E2 M
(Homo
sapiens) 		4 / 7 GLU A 142
LYS A 147
PRO A 141
ALA A 150
 None
 1.09A 2ejgA-1y8xA:
0.2		 2ejgA-1y8xA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1y8x UBIQUITIN-CONJUGATIN
G ENZYME E2 M
(Homo
sapiens) 		4 / 7 GLU A 142
LYS A 147
PRO A 141
ALA A 150
 None
 1.18A 2ejgB-1y8xA:
undetectable		 2ejgB-1y8xA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1y8x UBIQUITIN-CONJUGATIN
G ENZYME E2 M
(Homo
sapiens) 		3 / 3 PRO A 144
ASP A 143
GLU A 142
 None
 0.84A 3v4tC-1y8xA:
undetectable		 3v4tC-1y8xA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1y8x UBIQUITIN-CONJUGATIN
G ENZYME E2 M
(Homo
sapiens) 		5 / 12 TYR A  86
ILE A  34
ILE A 129
LEU A 132
VAL A 110
 None
 1.08A 3w68B-1y8xA:
undetectable		 3w68B-1y8xA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 1y8x UBIQUITIN-CONJUGATIN
G ENZYME E2 M
(Homo
sapiens) 		4 / 6 PRO A 139
GLY A  69
PHE A 160
ARG A 157
 None
 0.93A 5jcnB-1y8xA:
undetectable		 5jcnB-1y8xA:
15.84