SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y9a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		5 / 9 LEU A 189
ILE A 164
ARG A 301
VAL A 240
GLY A 263
 None
 1.24A 1e7aB-1y9aA:
undetectable		 1e7aB-1y9aA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		5 / 12 GLY A 244
GLY A 243
VAL A 178
LEU A 268
HIS A  42
 OHS  A 245 ( 2.4A)
None
None
None
None
 1.05A 1mx1F-1y9aA:
undetectable		 1mx1F-1y9aA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 7 ASN A 264
HIS A  42
TYR A 267
GLY A 243
 None
 1.34A 1mxgA-1y9aA:
undetectable		 1mxgA-1y9aA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		3 / 3 VAL A 253
ALA A 250
HIS A 247
 None
None
OHS  A 245 ( 3.7A)
 0.74A 1q23C-1y9aA:
undetectable		 1q23C-1y9aA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		3 / 3 VAL A 253
ALA A 250
HIS A 247
 None
None
OHS  A 245 ( 3.7A)
 0.74A 1q23H-1y9aA:
undetectable		 1q23H-1y9aA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		3 / 3 VAL A 253
ALA A 250
HIS A 247
 None
None
OHS  A 245 ( 3.7A)
 0.77A 1q23L-1y9aA:
undetectable		 1q23L-1y9aA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		3 / 3 VAL A 253
ALA A 250
HIS A 247
 None
None
OHS  A 245 ( 3.7A)
 0.75A 1q23J-1y9aA:
undetectable		 1q23J-1y9aA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		5 / 12 ILE A 216
ILE A 256
VAL A 236
ILE A 173
ILE A 262
 None
 1.26A 1r5lA-1y9aA:
undetectable		 1r5lA-1y9aA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		6 / 12 ALA A 196
GLY A 211
SER A 182
LEU A 180
MET A 181
LEU A 314
 None
 1.38A 1ya4A-1y9aA:
undetectable		 1ya4A-1y9aA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 6 PHE A 124
TYR A 353
ARG A 350
GLY A  63
 None
 1.42A 2i30A-1y9aA:
0.0		 2i30A-1y9aA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 5 LEU A 344
LEU A 319
CYH A  37
THR A  41
 None
None
ZN  A1000 ( 2.3A)
None
 1.17A 2oaxD-1y9aA:
undetectable		 2oaxD-1y9aA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		6 / 12 GLY A 155
ASN A 264
ILE A 241
GLY A 174
ILE A 175
VAL A 170
 None
 1.18A 2q64B-1y9aA:
undetectable		 2q64B-1y9aA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		5 / 9 LEU A 180
ILE A 175
GLY A 174
GLY A 243
CYH A 203
 None
 0.98A 2qmmA-1y9aA:
2.1		 2qmmA-1y9aA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		5 / 11 LEU A 180
ILE A 175
GLY A 174
GLY A 243
CYH A 203
 None
 0.98A 2qmmA-1y9aA:
2.1
2qmmB-1y9aA:
undetectable		 2qmmA-1y9aA:
20.66
2qmmB-1y9aA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		5 / 12 LEU A 327
LEU A  32
GLY A  63
GLN A  64
VAL A 126
 None
 1.37A 2w8yA-1y9aA:
undetectable		 2w8yA-1y9aA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		5 / 7 VAL A 178
ASN A 264
GLY A 263
VAL A 172
ASP A 261
 None
 1.38A 2y05A-1y9aA:
25.1
2y05B-1y9aA:
25.2		 2y05A-1y9aA:
25.59
2y05B-1y9aA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		5 / 12 GLY A 155
ILE A 241
GLY A 174
ILE A 175
VAL A 170
 None
 1.05A 3d1zA-1y9aA:
undetectable		 3d1zA-1y9aA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 8 GLY A 263
ILE A 164
VAL A 170
VAL A 172
 None
 0.80A 3fi0I-1y9aA:
undetectable		 3fi0I-1y9aA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		5 / 10 GLY A 155
ASN A 264
GLY A 174
ILE A 175
VAL A 170
 None
 0.83A 3lzvA-1y9aA:
undetectable		 3lzvA-1y9aA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 4 GLY A 286
TRP A 281
VAL A 253
SER A 260
 None
 1.40A 3n62A-1y9aA:
0.0		 3n62A-1y9aA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 4 GLY A 286
TRP A 281
VAL A 253
SER A 260
 None
 1.37A 3n65A-1y9aA:
0.0		 3n65A-1y9aA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 4 GLY A 286
TRP A 281
VAL A 253
SER A 260
 None
 1.38A 3n66A-1y9aA:
0.2		 3n66A-1y9aA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 7 ILE A 351
LYS A  17
PHE A 124
GLY A 118
 None
 1.24A 3sj0X-1y9aA:
undetectable		 3sj0X-1y9aA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 6 GLY A 158
VAL A 178
SER A 182
THR A 154
 None
None
None
CAC  A1001 (-3.3A)
 0.96A 3tj7A-1y9aA:
undetectable
3tj7B-1y9aA:
undetectable		 3tj7A-1y9aA:
19.10
3tj7B-1y9aA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 6 GLY A 158
VAL A 178
SER A 182
THR A 154
 None
None
None
CAC  A1001 (-3.3A)
 0.96A 3tj7C-1y9aA:
undetectable
3tj7D-1y9aA:
undetectable		 3tj7C-1y9aA:
19.10
3tj7D-1y9aA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		5 / 11 GLY A 155
ASN A 264
GLY A 243
GLY A 174
ILE A 175
 None
 0.88A 3ufnA-1y9aA:
undetectable		 3ufnA-1y9aA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 4 GLY A 286
TRP A 281
VAL A 253
SER A 260
 None
 1.30A 4d39A-1y9aA:
0.0		 4d39A-1y9aA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 6 ILE A 173
GLN A 251
ILE A 274
ASP A 275
 None
 1.18A 4w5qA-1y9aA:
undetectable		 4w5qA-1y9aA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 6 ILE A 173
GLN A 251
ILE A 274
ASP A 275
 None
 1.18A 4z4cA-1y9aA:
2.8		 4z4cA-1y9aA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 6 ILE A 173
GLN A 251
ILE A 274
ASP A 275
 None
 1.14A 4z4dA-1y9aA:
3.5		 4z4dA-1y9aA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		5 / 8 ILE A 140
VAL A 183
ILE A 206
ILE A 175
ILE A 345
 None
 1.46A 5hi2A-1y9aA:
undetectable		 5hi2A-1y9aA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		3 / 3 GLY A  23
ASP A  26
ASN A 132
 ACT  A1004 ( 4.2A)
None
None
 0.40A 5jglA-1y9aA:
8.0		 5jglA-1y9aA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 6 PHE A 112
VAL A  83
ALA A  85
THR A 153
 None
None
CAC  A1001 ( 4.0A)
None
 1.16A 5t7bA-1y9aA:
undetectable		 5t7bA-1y9aA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		3 / 3 GLY A 263
LEU A 161
HIS A 291
 None
 0.65A 5u63A-1y9aA:
3.5		 5u63A-1y9aA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		3 / 3 GLY A 263
LEU A 161
HIS A 291
 None
 0.63A 5u63B-1y9aA:
undetectable		 5u63B-1y9aA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		5 / 12 PHE A 120
ASP A  40
ILE A 345
ALA A  33
GLU A  60
 None
None
None
None
ZN  A1000 ( 4.6A)
 1.22A 5vcgA-1y9aA:
undetectable		 5vcgA-1y9aA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 5 GLY A 286
TRP A 281
VAL A 253
SER A 260
 None
 1.38A 5vunA-1y9aA:
undetectable		 5vunA-1y9aA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 4 HIS A 188
VAL A 152
LEU A 314
ALA A 184
 None
 1.39A 6d8pB-1y9aA:
undetectable		 6d8pB-1y9aA:
19.68