SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y9i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1y9i LOW TEMPERATURE
REQUIREMENT C
PROTEIN
(Listeria
monocytogenes) 		4 / 7 LEU A  80
GLN A  82
LEU A  71
PHE A 142
 None
 1.02A 2dysC-1y9iA:
undetectable
2dysJ-1y9iA:
undetectable		 2dysC-1y9iA:
22.83
2dysJ-1y9iA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 1y9i LOW TEMPERATURE
REQUIREMENT C
PROTEIN
(Listeria
monocytogenes) 		5 / 9 LEU A 158
VAL A  55
ILE A 105
GLY A 148
ILE A 120
 None
 1.12A 3ekqB-1y9iA:
undetectable		 3ekqB-1y9iA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1y9i LOW TEMPERATURE
REQUIREMENT C
PROTEIN
(Listeria
monocytogenes) 		5 / 10 ILE A 127
ILE A  28
VAL A  52
TYR A 117
LEU A 143
 None
 1.29A 3elzC-1y9iA:
undetectable		 3elzC-1y9iA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1y9i LOW TEMPERATURE
REQUIREMENT C
PROTEIN
(Listeria
monocytogenes) 		3 / 3 GLY A  22
ILE A 146
VAL A 147
 None
 0.50A 3nv6A-1y9iA:
undetectable		 3nv6A-1y9iA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 1y9i LOW TEMPERATURE
REQUIREMENT C
PROTEIN
(Listeria
monocytogenes) 		5 / 12 ILE A 105
ALA A 152
ILE A 120
LEU A 131
ILE A 146
 None
 1.11A 4km0B-1y9iA:
undetectable		 4km0B-1y9iA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 1y9i LOW TEMPERATURE
REQUIREMENT C
PROTEIN
(Listeria
monocytogenes) 		5 / 12 ILE A 105
ALA A 152
ILE A 120
LEU A 131
ILE A 146
 None
 1.14A 4km2A-1y9iA:
undetectable		 4km2A-1y9iA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 1y9i LOW TEMPERATURE
REQUIREMENT C
PROTEIN
(Listeria
monocytogenes) 		5 / 10 LEU A  56
VAL A 147
ILE A  69
LEU A 143
LEU A  10
 None
 1.15A 5ienB-1y9iA:
undetectable		 5ienB-1y9iA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 1y9i LOW TEMPERATURE
REQUIREMENT C
PROTEIN
(Listeria
monocytogenes) 		5 / 9 LEU A 158
VAL A  55
ILE A 105
GLY A 148
ILE A 120
 None
 1.11A 5kqxB-1y9iA:
undetectable		 5kqxB-1y9iA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 1y9i LOW TEMPERATURE
REQUIREMENT C
PROTEIN
(Listeria
monocytogenes) 		4 / 8 ILE A 120
PRO A 125
ILE A 127
ILE A  28
 None
 0.72A 5mvmA-1y9iA:
undetectable
5mvmB-1y9iA:
undetectable		 5mvmA-1y9iA:
19.30
5mvmB-1y9iA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 1y9i LOW TEMPERATURE
REQUIREMENT C
PROTEIN
(Listeria
monocytogenes) 		5 / 12 GLY A  42
TYR A  39
TYR A 162
GLN A  36
LEU A 158
 None
 1.42A 5v21A-1y9iA:
undetectable		 5v21A-1y9iA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 1y9i LOW TEMPERATURE
REQUIREMENT C
PROTEIN
(Listeria
monocytogenes) 		3 / 3 TYR A 119
ALA A 151
LEU A  31
 None
 0.68A 6ag0C-1y9iA:
undetectable		 6ag0C-1y9iA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1y9i LOW TEMPERATURE
REQUIREMENT C
PROTEIN
(Listeria
monocytogenes) 		5 / 11 VAL A  52
ALA A 154
LEU A  18
ALA A 151
LEU A  31
 None
 1.47A 6dk1B-1y9iA:
undetectable		 6dk1B-1y9iA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 1y9i LOW TEMPERATURE
REQUIREMENT C
PROTEIN
(Listeria
monocytogenes) 		3 / 3 VAL A  23
GLU A  24
ILE A 127
 None
 0.59A 6f7lB-1y9iA:
undetectable		 6f7lB-1y9iA:
17.12