SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y9q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 1y9q TRANSCRIPTIONAL
REGULATOR, HTH_3
FAMILY
(Vibrio
cholerae) 		5 / 12 LEU A  19
LEU A  16
ILE A  12
SER A  49
LEU A  63
 None
 1.04A 1xdkB-1y9qA:
undetectable		 1xdkB-1y9qA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 1y9q TRANSCRIPTIONAL
REGULATOR, HTH_3
FAMILY
(Vibrio
cholerae) 		3 / 3 GLN A  32
LYS A  38
VAL A  36
 None
 0.93A 2jfaB-1y9qA:
undetectable		 2jfaB-1y9qA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 1y9q TRANSCRIPTIONAL
REGULATOR, HTH_3
FAMILY
(Vibrio
cholerae) 		4 / 5 ILE A 109
HIS A 162
GLU A 128
HIS A 122
 None
ZN  A 202 ( 3.4A)
ZN  A 202 ( 2.5A)
ZN  A 202 ( 3.3A)
 0.95A 3ljgA-1y9qA:
undetectable		 3ljgA-1y9qA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1y9q TRANSCRIPTIONAL
REGULATOR, HTH_3
FAMILY
(Vibrio
cholerae) 		4 / 6 GLU A 128
TYR A 164
HIS A 115
VAL A 167
 ZN  A 202 ( 2.5A)
MED  A 201 ( 4.6A)
None
None
 1.13A 4a97E-1y9qA:
undetectable		 4a97E-1y9qA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1y9q TRANSCRIPTIONAL
REGULATOR, HTH_3
FAMILY
(Vibrio
cholerae) 		4 / 7 GLU A 105
LEU A  63
PHE A  70
TYR A 179
 None
 1.17A 4twdF-1y9qA:
1.8
4twdJ-1y9qA:
undetectable		 4twdF-1y9qA:
22.54
4twdJ-1y9qA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1y9q TRANSCRIPTIONAL
REGULATOR, HTH_3
FAMILY
(Vibrio
cholerae) 		5 / 12 SER A 120
PHE A   8
PHE A  70
LEU A  63
GLY A  35
 None
 1.41A 4zjlA-1y9qA:
undetectable		 4zjlA-1y9qA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1y9q TRANSCRIPTIONAL
REGULATOR, HTH_3
FAMILY
(Vibrio
cholerae) 		4 / 8 PHE A 156
GLY A 163
LEU A 111
MET A 137
 None
 0.93A 5esjA-1y9qA:
undetectable		 5esjA-1y9qA:
17.96