SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y9u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1y9u PUTATIVE IRON
BINDING PROTEIN
(Bordetella
pertussis) 		4 / 4 THR A 160
LEU A 164
VAL A 167
LEU A 171
 None
 0.68A 1fbmD-1y9uA:
undetectable		 1fbmD-1y9uA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1y9u PUTATIVE IRON
BINDING PROTEIN
(Bordetella
pertussis) 		4 / 5 THR A 160
LEU A 164
VAL A 167
LEU A 171
 None
 0.72A 1fbmE-1y9uA:
undetectable		 1fbmE-1y9uA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 1y9u PUTATIVE IRON
BINDING PROTEIN
(Bordetella
pertussis) 		5 / 10 LEU A 261
VAL A  34
VAL A  58
LEU A  22
TYR A 260
 None
 1.11A 1fkoA-1y9uA:
undetectable		 1fkoA-1y9uA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 1y9u PUTATIVE IRON
BINDING PROTEIN
(Bordetella
pertussis) 		5 / 10 ALA A 153
HIS A 154
LEU A 300
PRO A 301
ALA A 150
 None
 1.21A 1mjqG-1y9uA:
undetectable
1mjqH-1y9uA:
undetectable		 1mjqG-1y9uA:
16.86
1mjqH-1y9uA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1y9u PUTATIVE IRON
BINDING PROTEIN
(Bordetella
pertussis) 		4 / 4 THR A 160
LEU A 164
VAL A 167
LEU A 171
 None
 0.86A 1mz9D-1y9uA:
undetectable		 1mz9D-1y9uA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1y9u PUTATIVE IRON
BINDING PROTEIN
(Bordetella
pertussis) 		3 / 3 THR A 160
LEU A 164
VAL A 167
 None
 0.62A 1mz9E-1y9uA:
undetectable		 1mz9E-1y9uA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1y9u PUTATIVE IRON
BINDING PROTEIN
(Bordetella
pertussis) 		4 / 6 LEU A 125
ASN A 170
LEU A 171
PHE A 321
 None
 1.07A 1ru9H-1y9uA:
undetectable
1ru9L-1y9uA:
undetectable		 1ru9H-1y9uA:
20.68
1ru9L-1y9uA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1y9u PUTATIVE IRON
BINDING PROTEIN
(Bordetella
pertussis) 		4 / 6 LEU A 125
ASN A 170
LEU A 171
PHE A 321
 None
 1.11A 1rukH-1y9uA:
undetectable
1rukL-1y9uA:
undetectable		 1rukH-1y9uA:
20.68
1rukL-1y9uA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1y9u PUTATIVE IRON
BINDING PROTEIN
(Bordetella
pertussis) 		4 / 7 GLY A 178
TYR A 143
ASP A 181
ASP A 212
 None
 1.08A 2g72B-1y9uA:
undetectable		 2g72B-1y9uA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 1y9u PUTATIVE IRON
BINDING PROTEIN
(Bordetella
pertussis) 		4 / 7 VAL A 167
VAL A 316
ASP A 322
VAL A 319
 None
 0.84A 2qbnA-1y9uA:
undetectable		 2qbnA-1y9uA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 1y9u PUTATIVE IRON
BINDING PROTEIN
(Bordetella
pertussis) 		5 / 12 LEU A  59
ALA A 242
LEU A 257
LEU A 258
LEU A  10
 None
 1.10A 3erdA-1y9uA:
undetectable		 3erdA-1y9uA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 1y9u PUTATIVE IRON
BINDING PROTEIN
(Bordetella
pertussis) 		5 / 12 LEU A  59
ALA A 242
LEU A 257
LEU A 258
LEU A  10
 None
 1.09A 3hm1A-1y9uA:
undetectable		 3hm1A-1y9uA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 1y9u PUTATIVE IRON
BINDING PROTEIN
(Bordetella
pertussis) 		5 / 9 ARG A 121
GLY A 194
ILE A 193
PRO A 225
THR A 226
 None
 1.34A 3spkA-1y9uA:
undetectable		 3spkA-1y9uA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1y9u PUTATIVE IRON
BINDING PROTEIN
(Bordetella
pertussis) 		4 / 7 ALA A 183
ILE A 186
ARG A 173
GLY A 194
 None
 0.94A 3v4tH-1y9uA:
undetectable		 3v4tH-1y9uA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1y9u PUTATIVE IRON
BINDING PROTEIN
(Bordetella
pertussis) 		3 / 3 TYR A 200
HIS A 141
ARG A 137
 None
 1.15A 4htfA-1y9uA:
undetectable		 4htfA-1y9uA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 1y9u PUTATIVE IRON
BINDING PROTEIN
(Bordetella
pertussis) 		4 / 6 LEU A  44
LEU A  67
THR A  13
VAL A  39
 None
 1.11A 4udaA-1y9uA:
undetectable		 4udaA-1y9uA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 1y9u PUTATIVE IRON
BINDING PROTEIN
(Bordetella
pertussis) 		5 / 11 LEU A  59
ALA A 242
LEU A 257
LEU A 258
LEU A  10
 None
 1.11A 4zn7B-1y9uA:
undetectable		 4zn7B-1y9uA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1y9u PUTATIVE IRON
BINDING PROTEIN
(Bordetella
pertussis) 		5 / 12 LEU A 261
VAL A  34
VAL A  58
LEU A  22
TYR A 260
 None
 1.14A 5cymA-1y9uA:
0.0		 5cymA-1y9uA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1y9u PUTATIVE IRON
BINDING PROTEIN
(Bordetella
pertussis) 		5 / 12 LEU A 261
VAL A  34
VAL A  58
LEU A  22
TYR A 260
 None
 1.15A 5cyqA-1y9uA:
undetectable		 5cyqA-1y9uA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 1y9u PUTATIVE IRON
BINDING PROTEIN
(Bordetella
pertussis) 		5 / 12 SER A 103
LEU A 102
GLY A 241
VAL A  62
LEU A 261
 None
 1.37A 5jo9A-1y9uA:
undetectable		 5jo9A-1y9uA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1y9u PUTATIVE IRON
BINDING PROTEIN
(Bordetella
pertussis) 		4 / 6 LEU A 171
VAL A 167
LEU A 125
ARG A 107
 None
 0.91A 5x7zA-1y9uA:
undetectable		 5x7zA-1y9uA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 1y9u PUTATIVE IRON
BINDING PROTEIN
(Bordetella
pertussis) 		3 / 3 ARG A 180
ARG A 105
ARG A 137
 None
 0.89A 6bplA-1y9uA:
undetectable
6bplB-1y9uA:
undetectable		 6bplA-1y9uA:
21.47
6bplB-1y9uA:
21.47