SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ya0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 1ya0 SMG-7 TRANSCRIPT
VARIANT 2
(Homo
sapiens) 		3 / 3 ASP A 160
ARG A 163
ILE A 194
 None
SO4  A 498 (-3.1A)
None
 0.81A 1a4gB-1ya0A:
undetectable		 1a4gB-1ya0A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 1ya0 SMG-7 TRANSCRIPT
VARIANT 2
(Homo
sapiens) 		3 / 3 PHE A 303
LEU A 226
LEU A 230
 None
 0.63A 1mx1E-1ya0A:
undetectable		 1mx1E-1ya0A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 1ya0 SMG-7 TRANSCRIPT
VARIANT 2
(Homo
sapiens) 		3 / 3 ARG A 455
VAL A 299
GLY A 423
 None
 0.45A 2avvE-1ya0A:
undetectable		 2avvE-1ya0A:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 1ya0 SMG-7 TRANSCRIPT
VARIANT 2
(Homo
sapiens) 		4 / 6 ALA A 381
ASP A 384
GLU A 380
ARG A 309
 None
 1.43A 2ouzA-1ya0A:
1.8		 2ouzA-1ya0A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1ya0 SMG-7 TRANSCRIPT
VARIANT 2
(Homo
sapiens) 		4 / 7 TYR A 102
TRP A  61
GLN A  41
TYR A  40
 None
 1.33A 2ph9A-1ya0A:
undetectable
2ph9B-1ya0A:
undetectable		 2ph9A-1ya0A:
20.26
2ph9B-1ya0A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 1ya0 SMG-7 TRANSCRIPT
VARIANT 2
(Homo
sapiens) 		4 / 8 ILE A 466
GLY A 463
LEU A 397
LEU A 396
 None
 0.67A 2vctA-1ya0A:
4.0		 2vctA-1ya0A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 1ya0 SMG-7 TRANSCRIPT
VARIANT 2
(Homo
sapiens) 		4 / 8 ILE A 466
GLY A 463
LEU A 397
LEU A 396
 None
 0.63A 2vctB-1ya0A:
3.9		 2vctB-1ya0A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 1ya0 SMG-7 TRANSCRIPT
VARIANT 2
(Homo
sapiens) 		4 / 8 ILE A 466
GLY A 463
LEU A 397
LEU A 396
 None
 0.62A 2vctC-1ya0A:
4.1		 2vctC-1ya0A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1ya0 SMG-7 TRANSCRIPT
VARIANT 2
(Homo
sapiens) 		4 / 7 TYR A 102
PHE A  65
LEU A  36
ALA A  64
 None
 1.15A 2vcvA-1ya0A:
undetectable		 2vcvA-1ya0A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 1ya0 SMG-7 TRANSCRIPT
VARIANT 2
(Homo
sapiens) 		5 / 12 LEU A 302
SER A 430
VAL A 295
HIS A 296
LEU A 203
 None
 1.16A 2zlcA-1ya0A:
undetectable		 2zlcA-1ya0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ya0 SMG-7 TRANSCRIPT
VARIANT 2
(Homo
sapiens) 		5 / 12 LEU A 203
PHE A 256
HIS A 257
LEU A 331
LEU A 302
 None
 1.23A 3adsA-1ya0A:
0.0		 3adsA-1ya0A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 1ya0 SMG-7 TRANSCRIPT
VARIANT 2
(Homo
sapiens) 		4 / 5 PRO A 490
ILE A 489
PRO A 391
TYR A 388
 None
 1.11A 3d9lA-1ya0A:
3.1
3d9lY-1ya0A:
undetectable		 3d9lA-1ya0A:
13.69
3d9lY-1ya0A:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ya0 SMG-7 TRANSCRIPT
VARIANT 2
(Homo
sapiens) 		5 / 6 VAL A 297
LEU A 459
ILE A 389
ALA A 363
LEU A 294
 None
 1.43A 3kk6B-1ya0A:
undetectable		 3kk6B-1ya0A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 1ya0 SMG-7 TRANSCRIPT
VARIANT 2
(Homo
sapiens) 		4 / 7 TYR A 261
LEU A 203
LEU A 226
PHE A 303
 None
 1.25A 3nk2X-1ya0A:
undetectable		 3nk2X-1ya0A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 1ya0 SMG-7 TRANSCRIPT
VARIANT 2
(Homo
sapiens) 		5 / 12 THR A 298
GLY A 340
ALA A 358
ASN A 357
GLN A 456
 None
 1.16A 3v3oA-1ya0A:
undetectable		 3v3oA-1ya0A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1ya0 SMG-7 TRANSCRIPT
VARIANT 2
(Homo
sapiens) 		4 / 8 GLU A 172
GLN A 292
ILE A 250
VAL A 246
 None
 0.97A 4dx7B-1ya0A:
3.4		 4dx7B-1ya0A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 1ya0 SMG-7 TRANSCRIPT
VARIANT 2
(Homo
sapiens) 		3 / 3 GLU A 420
THR A 204
HIS A 296
 None
 0.60A 4q15A-1ya0A:
undetectable		 4q15A-1ya0A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 1ya0 SMG-7 TRANSCRIPT
VARIANT 2
(Homo
sapiens) 		3 / 3 GLU A 420
THR A 204
HIS A 296
 None
 0.62A 4q15B-1ya0A:
undetectable		 4q15B-1ya0A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 1ya0 SMG-7 TRANSCRIPT
VARIANT 2
(Homo
sapiens) 		5 / 12 GLY A 186
ASN A 190
PRO A 220
ALA A 221
PHE A 217
 None
 1.13A 4rvgA-1ya0A:
undetectable		 4rvgA-1ya0A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 1ya0 SMG-7 TRANSCRIPT
VARIANT 2
(Homo
sapiens) 		4 / 6 LEU A 272
LEU A 334
ILE A 254
PHE A 253
 None
 0.97A 4y4dA-1ya0A:
undetectable		 4y4dA-1ya0A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 1ya0 SMG-7 TRANSCRIPT
VARIANT 2
(Homo
sapiens) 		3 / 3 GLU A 420
THR A 204
HIS A 296
 None
 0.61A 4ydqB-1ya0A:
undetectable		 4ydqB-1ya0A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 1ya0 SMG-7 TRANSCRIPT
VARIANT 2
(Homo
sapiens) 		3 / 3 TYR A  40
HIS A  63
MET A  19
 None
 1.10A 6af6A-1ya0A:
undetectable		 6af6A-1ya0A:
22.72