SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yaa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 1yaa ASPARTATE
AMINOTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 10 LEU A  79
VAL A 103
ILE A 114
GLY A 110
PRO A 298
 None
 1.24A 1d4sA-1yaaA:
undetectable		 1d4sA-1yaaA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1yaa ASPARTATE
AMINOTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 8 SER A 105
HIS A 269
ILE A  87
VAL A 306
 None
 1.16A 1kb9A-1yaaA:
0.8
1kb9C-1yaaA:
0.0
1kb9D-1yaaA:
0.0
1kb9E-1yaaA:
0.0		 1kb9A-1yaaA:
22.25
1kb9C-1yaaA:
22.10
1kb9D-1yaaA:
21.53
1kb9E-1yaaA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1yaa ASPARTATE
AMINOTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 122
LEU A 270
PHE A 123
SER A 115
 None
 0.92A 1wrlC-1yaaA:
undetectable
1wrlD-1yaaA:
undetectable		 1wrlC-1yaaA:
12.35
1wrlD-1yaaA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 1yaa ASPARTATE
AMINOTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 8 ILE A  86
ILE A  87
VAL A 252
ALA A 269
 None
 0.63A 2nniA-1yaaA:
undetectable		 2nniA-1yaaA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 1yaa ASPARTATE
AMINOTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 307
PHE A 256
GLY A 268
SER A  81
ALA A  83
 None
 1.35A 2vh3A-1yaaA:
0.0		 2vh3A-1yaaA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 1yaa ASPARTATE
AMINOTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 337
VAL A 379
LEU A 381
VAL A  33
 None
 0.85A 2zujA-1yaaA:
undetectable		 2zujA-1yaaA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 1yaa ASPARTATE
AMINOTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 8 THR A 363
VAL A 379
LEU A 381
VAL A  33
 None
 0.77A 2zujA-1yaaA:
undetectable		 2zujA-1yaaA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 1yaa ASPARTATE
AMINOTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 174
GLY A 172
LEU A 170
ILE A 208
LEU A 188
 None
 0.95A 3gwvA-1yaaA:
undetectable		 3gwvA-1yaaA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1yaa ASPARTATE
AMINOTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  83
LEU A 233
SER A  78
GLY A 227
ILE A  87
 None
 1.21A 3lbdA-1yaaA:
undetectable		 3lbdA-1yaaA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEE_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 1yaa ASPARTATE
AMINOTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 PRO A 200
LEU A 170
TYR A 160
TYR A 158
LEU A 174
 None
 1.43A 3meeA-1yaaA:
1.5		 3meeA-1yaaA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEG_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 1yaa ASPARTATE
AMINOTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 PRO A 200
LEU A 170
TYR A 160
TYR A 158
LEU A 174
 None
 1.40A 3megA-1yaaA:
1.5		 3megA-1yaaA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEG_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 1yaa ASPARTATE
AMINOTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 PRO A 200
LEU A 170
TYR A 160
TYR A 158
PHE A 186
 None
 1.45A 3megA-1yaaA:
1.5		 3megA-1yaaA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1yaa ASPARTATE
AMINOTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 8 ILE A  86
LEU A 310
VAL A 267
GLY A 268
 None
 0.90A 3w1wA-1yaaA:
2.3		 3w1wA-1yaaA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1yaa ASPARTATE
AMINOTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 103
ILE A 101
GLU A 294
ILE A 146
VAL A 283
 None
 1.00A 4a97B-1yaaA:
undetectable
4a97C-1yaaA:
undetectable		 4a97B-1yaaA:
22.17
4a97C-1yaaA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 1yaa ASPARTATE
AMINOTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 208
TYR A 158
TYR A 160
PHE A 173
 None
 1.21A 4g10A-1yaaA:
undetectable		 4g10A-1yaaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1yaa ASPARTATE
AMINOTRANSFERASE
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 315
LEU A 233
ASN A  82
 None
 0.69A 4otwA-1yaaA:
undetectable		 4otwA-1yaaA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1yaa ASPARTATE
AMINOTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 7 LEU A 392
LEU A 337
ALA A 401
ALA A 403
LEU A  35
 None
 1.30A 4z90F-1yaaA:
undetectable
4z90G-1yaaA:
undetectable
4z90H-1yaaA:
undetectable
4z90J-1yaaA:
undetectable		 4z90F-1yaaA:
23.08
4z90G-1yaaA:
23.08
4z90H-1yaaA:
23.08
4z90J-1yaaA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 1yaa ASPARTATE
AMINOTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 379
LEU A 337
ILE A 404
ALA A 403
 None
 0.55A 4zf8A-1yaaA:
undetectable		 4zf8A-1yaaA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1yaa ASPARTATE
AMINOTRANSFERASE
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 147
ILE A 185
ASP A 130
 None
 0.58A 5cswA-1yaaA:
undetectable		 5cswA-1yaaA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1yaa ASPARTATE
AMINOTRANSFERASE
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 147
ILE A 185
ASP A 130
 None
 0.62A 5cswB-1yaaA:
undetectable		 5cswB-1yaaA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 1yaa ASPARTATE
AMINOTRANSFERASE
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 172
ASP A 169
ASN A 163
 None
 0.39A 5jglA-1yaaA:
undetectable		 5jglA-1yaaA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1yaa ASPARTATE
AMINOTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 8 ALA A 403
LEU A 392
LEU A  35
LEU A 341
LEU A 337
 None
 1.47A 5jqbA-1yaaA:
undetectable
5jqbB-1yaaA:
0.0		 5jqbA-1yaaA:
23.13
5jqbB-1yaaA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 1yaa ASPARTATE
AMINOTRANSFERASE
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 194
TYR A 225
CYH A 357
 MAE  A 901 ( 3.4A)
PLP  A 905 (-4.2A)
None
 1.01A 5lsuB-1yaaA:
undetectable		 5lsuB-1yaaA:
19.76