SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yac'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 1yac YCAC GENE PRODUCT
(Escherichia
coli) 		5 / 12 ALA A  13
ILE A  82
THR A  57
LEU A  56
LEU A  43
 None
 1.41A 1eiiA-1yacA:
undetectable		 1eiiA-1yacA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 1yac YCAC GENE PRODUCT
(Escherichia
coli) 		4 / 6 GLN A  21
CYH A 118
ASP A  19
VAL A 114
 None
 1.50A 1ekjG-1yacA:
2.1
1ekjH-1yacA:
2.9		 1ekjG-1yacA:
19.75
1ekjH-1yacA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 1yac YCAC GENE PRODUCT
(Escherichia
coli) 		4 / 6 GLN A  75
ASP A  45
VAL A  40
HIS A 190
 None
 1.11A 1ekjG-1yacA:
2.1
1ekjH-1yacA:
2.9		 1ekjG-1yacA:
19.75
1ekjH-1yacA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 1yac YCAC GENE PRODUCT
(Escherichia
coli) 		4 / 7 PHE A  50
ALA A  42
LEU A  43
VAL A 136
 None
 0.94A 1hk2A-1yacA:
undetectable		 1hk2A-1yacA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1yac YCAC GENE PRODUCT
(Escherichia
coli) 		4 / 6 LEU A  24
ASP A  19
ILE A  88
ARG A  84
 None
 1.04A 1mt1A-1yacA:
undetectable
1mt1F-1yacA:
undetectable		 1mt1A-1yacA:
17.33
1mt1F-1yacA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1yac YCAC GENE PRODUCT
(Escherichia
coli) 		4 / 6 ILE A  88
ARG A  84
LEU A  24
ASP A  19
 None
 1.01A 1mt1B-1yacA:
undetectable
1mt1C-1yacA:
undetectable		 1mt1B-1yacA:
18.18
1mt1C-1yacA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1yac YCAC GENE PRODUCT
(Escherichia
coli) 		4 / 7 ILE A  88
ARG A  84
LEU A  24
ASP A  19
 None
 1.01A 2qqcB-1yacA:
undetectable
2qqcC-1yacA:
undetectable		 2qqcB-1yacA:
18.18
2qqcC-1yacA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1yac YCAC GENE PRODUCT
(Escherichia
coli) 		4 / 7 LEU A  24
ASP A  19
ILE A  88
ARG A  84
 None
 1.01A 2qqcA-1yacA:
undetectable
2qqcF-1yacA:
undetectable		 2qqcA-1yacA:
16.67
2qqcF-1yacA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1yac YCAC GENE PRODUCT
(Escherichia
coli) 		4 / 7 LEU A  24
ASP A  19
ILE A  88
ARG A  84
 None
 1.02A 2qqcG-1yacA:
undetectable
2qqcJ-1yacA:
undetectable		 2qqcG-1yacA:
16.67
2qqcJ-1yacA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1yac YCAC GENE PRODUCT
(Escherichia
coli) 		4 / 7 LEU A  24
ASP A  19
ILE A  88
ARG A  84
 None
 0.98A 2qqcI-1yacA:
undetectable
2qqcL-1yacA:
undetectable		 2qqcI-1yacA:
16.67
2qqcL-1yacA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1yac YCAC GENE PRODUCT
(Escherichia
coli) 		4 / 7 LEU A  24
ASP A  19
ILE A  88
ARG A  84
 None
 1.05A 2qqdA-1yacA:
undetectable
2qqdE-1yacA:
undetectable		 2qqdA-1yacA:
16.93
2qqdE-1yacA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1yac YCAC GENE PRODUCT
(Escherichia
coli) 		5 / 12 LEU A  17
LEU A  52
ILE A 109
ALA A  42
ALA A  47
 None
 1.00A 3mdvB-1yacA:
undetectable		 3mdvB-1yacA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 1yac YCAC GENE PRODUCT
(Escherichia
coli) 		3 / 3 THR A 137
ASN A 144
PHE A 143
 None
 0.74A 4pd9A-1yacA:
undetectable		 4pd9A-1yacA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1yac YCAC GENE PRODUCT
(Escherichia
coli) 		4 / 4 PHE A 131
VAL A 100
ALA A 126
PHE A  96
 None
 1.49A 4w5tA-1yacA:
3.4		 4w5tA-1yacA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1yac YCAC GENE PRODUCT
(Escherichia
coli) 		3 / 3 ASN A  38
VAL A 113
HIS A  20
 None
 0.85A 6a5yD-1yacA:
undetectable		 6a5yD-1yacA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 1yac YCAC GENE PRODUCT
(Escherichia
coli) 		3 / 3 LEU A 186
SER A 188
PHE A 187
 None
 0.67A 6fgcA-1yacA:
undetectable		 6fgcA-1yacA:
19.95