SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yad'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1D4S_A_TPVA201_2 (PROTEIN (HIV-1 PROTEASE))	1yad	REGULATORY PROTEIN TENI (Bacillus subtilis)	4 / 8	ARG A 190 ALA A 5 ILE A 19 VAL A 27	None	0.78A	1d4sB-1yadA: undetectable	1d4sB-1yadA: 19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DDW_A_PXLA1003_1 (PYRIDOXINE KINASE)	1yad	REGULATORY PROTEIN TENI (Bacillus subtilis)	4 / 8	VAL A 76 VAL A 65 PRO A 79 ASP A 66	None None 144 A 300 ( 3.3A) None	0.89A	2ddwA-1yadA: undetectable	2ddwA-1yadA: 21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DU8_B_BEZB1352_0 (D-AMINO-ACID OXIDASE)	1yad	REGULATORY PROTEIN TENI (Bacillus subtilis)	4 / 6	LEU A 3 TYR A 192 ILE A 179 GLY A 155	None None None SO4 A 291 ( 4.0A)	0.95A	2du8B-1yadA: undetectable	2du8B-1yadA: 20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IV6_D_SAMD301_0 (PUTATIVE ZN-DEPENDENT ALCOHOL DEHYDROGENASE)	1yad	REGULATORY PROTEIN TENI (Bacillus subtilis)	5 / 12	ILE A 32 ASP A 55 ARG A 57 LEU A 59 ARG A 75	None	1.27A	3iv6D-1yadA: undetectable	3iv6D-1yadA: 21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DTA_A_ADNA401_1 (APH(2'')-ID)	1yad	REGULATORY PROTEIN TENI (Bacillus subtilis)	5 / 10	PRO A 85 ILE A 88 HIS A 96 LEU A 95 ASP A 116	None	1.26A	4dtaA-1yadA: undetectable	4dtaA-1yadA: 21.36

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1D4S_A_TPVA201_2","PROTEIN (HIV-1 PROTEASE);PROTEIN (HIV-1 PROTEASE)","1yad","REGULATORY PROTEIN TENI","Bacillus subtilis",4,"ARG A 190;ALA A   5;ILE A  19;VAL A  27","None","0.78A","1d4sB-1yadA:undetectable","1d4sB-1yadA:19.52"],["2DDW_A_PXLA1003_1","PYRIDOXINE KINASE","1yad","REGULATORY PROTEIN TENI","Bacillus subtilis",4,"VAL A  76;VAL A  65;PRO A  79;ASP A  66","None;None;144 A 300 ( 3.3A);None","0.89A","2ddwA-1yadA:undetectable","2ddwA-1yadA:21.65"],["2DU8_B_BEZB1352_0","D-AMINO-ACID OXIDASE","1yad","REGULATORY PROTEIN TENI","Bacillus subtilis",4,"LEU A   3;TYR A 192;ILE A 179;GLY A 155","None;None;None;SO4 A 291 ( 4.0A)","0.95A","2du8B-1yadA:undetectable","2du8B-1yadA:20.39"],["3IV6_D_SAMD301_0","PUTATIVE ZN-DEPENDENT ALCOHOL DEHYDROGENASE","1yad","REGULATORY PROTEIN TENI","Bacillus subtilis",5,"ILE A  32;ASP A  55;ARG A  57;LEU A  59;ARG A  75","None","1.27A","3iv6D-1yadA:undetectable","3iv6D-1yadA:21.99"],["4DTA_A_ADNA401_1","APH(2'')-ID","1yad","REGULATORY PROTEIN TENI","Bacillus subtilis",5,"PRO A  85;ILE A  88;HIS A  96;LEU A  95;ASP A 116","None","1.26A","4dtaA-1yadA:undetectable","4dtaA-1yadA:21.36"]]