SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yal'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 1yal CHYMOPAPAIN
(Carica
papaya) 		7 / 10 GLN A  19
GLY A  23
SER A  24
PHE A  28
SER A  29
ALA A 160
GLY A  65
 None
 1.23A 1stfE-1yalA:
37.9
1stfI-1yalA:
undetectable		 1stfE-1yalA:
57.47
1stfI-1yalA:
17.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 1yal CHYMOPAPAIN
(Carica
papaya) 		8 / 10 GLN A  19
GLY A  23
SER A  24
TRP A  26
PHE A  28
SER A  29
HIS A 159
ALA A 160
 None
 0.49A 1stfE-1yalA:
37.9
1stfI-1yalA:
undetectable		 1stfE-1yalA:
57.47
1stfI-1yalA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 1yal CHYMOPAPAIN
(Carica
papaya) 		4 / 5 LEU A 125
ARG A 195
ALA A 124
ILE A 175
 None
 1.05A 2qhfA-1yalA:
undetectable		 2qhfA-1yalA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 1yal CHYMOPAPAIN
(Carica
papaya) 		4 / 7 GLN A  19
GLY A  23
HIS A 159
TRP A 181
 None
 0.38A 3ai8A-1yalA:
28.6		 3ai8A-1yalA:
29.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1yal CHYMOPAPAIN
(Carica
papaya) 		4 / 8 VAL A 161
MET A 191
ILE A 177
ASN A 179
 None
 0.85A 4a97C-1yalA:
undetectable		 4a97C-1yalA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1yal CHYMOPAPAIN
(Carica
papaya) 		4 / 8 VAL A 161
MET A 191
ILE A 177
ASN A 179
 None
 0.93A 4a97D-1yalA:
undetectable		 4a97D-1yalA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1yal CHYMOPAPAIN
(Carica
papaya) 		4 / 8 VAL A 161
MET A 191
ILE A 177
ASN A 179
 None
 0.90A 4a97G-1yalA:
undetectable		 4a97G-1yalA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1yal CHYMOPAPAIN
(Carica
papaya) 		4 / 8 VAL A 161
MET A 191
ILE A 177
ASN A 179
 None
 0.91A 4a97I-1yalA:
undetectable		 4a97I-1yalA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1yal CHYMOPAPAIN
(Carica
papaya) 		3 / 3 PHE A  28
VAL A 164
ILE A 177
 None
 0.61A 4emaA-1yalA:
undetectable		 4emaA-1yalA:
19.66