SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yax'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EUP_A_ASDA452_1 (CYTOCHROME P450ERYF)	1yax	VIRULENCE SENSOR PROTEIN PHOQ, SENSOR DOMAIN (Salmonella enterica)	4 / 8	SER A 108 ILE A 109 LEU A 105 LEU A 95	None	0.81A	1eupA-1yaxA: undetectable	1eupA-1yaxA: 17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4X20_D_LOCD502_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	1yax	VIRULENCE SENSOR PROTEIN PHOQ, SENSOR DOMAIN (Salmonella enterica)	3 / 3	SER A 158 ALA A 160 VAL A 161	None	0.65A	4x20C-1yaxA: undetectable	4x20C-1yaxA: 13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TIW_A_OAQA302_0 (SULFOTRANSFERASE)	1yax	VIRULENCE SENSOR PROTEIN PHOQ, SENSOR DOMAIN (Salmonella enterica)	5 / 12	LEU A 74 ILE A 70 LEU A 87 PHE A 59 LEU A 95	None	1.28A	5tiwA-1yaxA: undetectable	5tiwA-1yaxA: 22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NMF_W_CHDW101_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	1yax	VIRULENCE SENSOR PROTEIN PHOQ, SENSOR DOMAIN (Salmonella enterica)	4 / 6	ILE A 88 LEU A 96 MET A 170 THR A 167	None	1.10A	6nmfN-1yaxA: undetectable 6nmfW-1yaxA: undetectable	6nmfN-1yaxA: 14.62 6nmfW-1yaxA: 14.19

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1EUP_A_ASDA452_1","CYTOCHROME P450ERYF","1yax","VIRULENCE SENSOR PROTEIN PHOQ, SENSOR DOMAIN","Salmonella enterica",4,"SER A 108;ILE A 109;LEU A 105;LEU A  95","None","0.81A","1eupA-1yaxA:undetectable","1eupA-1yaxA:17.38"],["4X20_D_LOCD502_1","TUBULIN ALPHA CHAIN;TUBULIN BETA CHAIN","1yax","VIRULENCE SENSOR PROTEIN PHOQ, SENSOR DOMAIN","Salmonella enterica",3,"SER A 158;ALA A 160;VAL A 161","None","0.65A","4x20C-1yaxA:undetectable","4x20C-1yaxA:13.69"],["5TIW_A_OAQA302_0","SULFOTRANSFERASE","1yax","VIRULENCE SENSOR PROTEIN PHOQ, SENSOR DOMAIN","Salmonella enterica",5,"LEU A  74;ILE A  70;LEU A  87;PHE A  59;LEU A  95","None","1.28A","5tiwA-1yaxA:undetectable","5tiwA-1yaxA:22.84"],["6NMF_W_CHDW101_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","1yax","VIRULENCE SENSOR PROTEIN PHOQ, SENSOR DOMAIN","Salmonella enterica",4,"ILE A  88;LEU A  96;MET A 170;THR A 167","None","1.10A","6nmfN-1yaxA:undetectable;6nmfW-1yaxA:undetectable","6nmfN-1yaxA:14.62;6nmfW-1yaxA:14.19"]]