SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yb1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 1yb1 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE
TYPE XI
(Homo
sapiens) 		5 / 11 SER A  56
LEU A  58
LEU A 241
VAL A  34
ILE A 245
 None
 1.13A 1ee2A-1yb1A:
8.9		 1ee2A-1yb1A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 1yb1 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE
TYPE XI
(Homo
sapiens) 		5 / 11 SER A  56
LEU A  58
LEU A 241
VAL A  34
ILE A 245
 None
 1.15A 1ee2B-1yb1A:
8.9		 1ee2B-1yb1A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 1yb1 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE
TYPE XI
(Homo
sapiens) 		5 / 11 THR A 209
VAL A  34
VAL A 113
GLU A  32
LEU A 246
 None
 1.30A 1t6zA-1yb1A:
2.4		 1t6zA-1yb1A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 1yb1 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE
TYPE XI
(Homo
sapiens) 		5 / 11 LEU A  35
LEU A 112
ALA A 149
LEU A 151
THR A 146
 None
None
None
AOI  A 602 ( 4.6A)
None
 1.20A 1tz8A-1yb1A:
undetectable
1tz8B-1yb1A:
undetectable		 1tz8A-1yb1A:
19.71
1tz8B-1yb1A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1yb1 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE
TYPE XI
(Homo
sapiens) 		5 / 12 GLY A  38
ASP A  62
ASP A  88
CYH A  89
ASN A 115
 CL  A 402 ( 3.7A)
CL  A 402 (-3.6A)
CL  A 405 ( 4.9A)
CL  A 405 (-4.6A)
SO4  A 702 ( 4.7A)
 1.14A 2bm9B-1yb1A:
4.8		 2bm9B-1yb1A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1yb1 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE
TYPE XI
(Homo
sapiens) 		6 / 12 GLY A  38
ASP A  62
ASP A  88
CYH A  89
ASN A 115
ALA A 116
 CL  A 402 ( 3.7A)
CL  A 402 (-3.6A)
CL  A 405 ( 4.9A)
CL  A 405 (-4.6A)
SO4  A 702 ( 4.7A)
CL  A 402 ( 4.1A)
 1.00A 2bm9E-1yb1A:
5.6		 2bm9E-1yb1A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1yb1 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE
TYPE XI
(Homo
sapiens) 		5 / 12 GLY A  38
ASP A  88
CYH A  89
SER A  90
ALA A 116
 CL  A 402 ( 3.7A)
CL  A 405 ( 4.9A)
CL  A 405 (-4.6A)
None
CL  A 402 ( 4.1A)
 0.91A 2br4C-1yb1A:
5.4		 2br4C-1yb1A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_1
(HYPOTHETICAL PROTEIN
LMO1582)		 1yb1 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE
TYPE XI
(Homo
sapiens) 		4 / 4 THR A  47
THR A  71
ASP A  62
ASP A  88
 None
None
CL  A 402 (-3.6A)
CL  A 405 ( 4.9A)
 1.16A 2f8lA-1yb1A:
2.9		 2f8lA-1yb1A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1yb1 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE
TYPE XI
(Homo
sapiens) 		4 / 7 SER A 256
SER A 225
THR A 226
ASN A 223
 CL  A 401 (-2.9A)
None
CL  A 401 ( 4.8A)
None
 0.89A 2i91A-1yb1A:
4.5		 2i91A-1yb1A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1yb1 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE
TYPE XI
(Homo
sapiens) 		4 / 7 SER A 256
SER A 225
THR A 226
ASN A 223
 CL  A 401 (-2.9A)
None
CL  A 401 ( 4.8A)
None
 0.89A 2i91B-1yb1A:
undetectable		 2i91B-1yb1A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 1yb1 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE
TYPE XI
(Homo
sapiens) 		4 / 8 THR A 195
VAL A 163
ASN A 114
ALA A 187
 None
 0.91A 2ij7C-1yb1A:
undetectable		 2ij7C-1yb1A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 1yb1 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE
TYPE XI
(Homo
sapiens) 		4 / 6 THR A  47
THR A  71
ASP A  62
ASP A  88
 None
None
CL  A 402 (-3.6A)
CL  A 405 ( 4.9A)
 1.24A 2okcA-1yb1A:
5.9		 2okcA-1yb1A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 1yb1 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE
TYPE XI
(Homo
sapiens) 		4 / 6 THR A  47
THR A  71
ASP A  62
ASP A  88
 None
None
CL  A 402 (-3.6A)
CL  A 405 ( 4.9A)
 1.29A 2okcB-1yb1A:
5.9		 2okcB-1yb1A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 1yb1 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE
TYPE XI
(Homo
sapiens) 		3 / 3 PHE A  51
SER A 110
LEU A 112
 None
 0.82A 2w1bA-1yb1A:
undetectable		 2w1bA-1yb1A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 1yb1 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE
TYPE XI
(Homo
sapiens) 		5 / 10 GLY A  40
ASP A  62
ILE A  63
ASN A  64
ASP A  88
 None
CL  A 402 (-3.6A)
CL  A 405 (-4.0A)
None
CL  A 405 ( 4.9A)
 0.73A 3ay0B-1yb1A:
7.3		 3ay0B-1yb1A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)		 1yb1 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE
TYPE XI
(Homo
sapiens) 		5 / 9 GLY A 117
ALA A 116
GLY A  44
ILE A  43
THR A 164
 None
CL  A 402 ( 4.1A)
None
SO4  A 702 (-3.8A)
None
 1.04A 3gguB-1yb1A:
undetectable		 3gguB-1yb1A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 1yb1 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE
TYPE XI
(Homo
sapiens) 		4 / 8 GLY A 117
ALA A 116
GLY A  44
ILE A  43
 None
CL  A 402 ( 4.1A)
None
SO4  A 702 (-3.8A)
 0.69A 3so9A-1yb1A:
undetectable		 3so9A-1yb1A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1yb1 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE
TYPE XI
(Homo
sapiens) 		6 / 12 GLY A  38
GLY A  40
ASP A  62
ILE A  63
ASP A  88
ALA A 116
 CL  A 402 ( 3.7A)
None
CL  A 402 (-3.6A)
CL  A 405 (-4.0A)
CL  A 405 ( 4.9A)
CL  A 402 ( 4.1A)
 1.03A 4iv8A-1yb1A:
6.3		 4iv8A-1yb1A:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1yb1 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE
TYPE XI
(Homo
sapiens) 		6 / 12 GLY A  38
GLY A  40
ASP A  62
ILE A  63
ASP A  88
ALA A 116
 CL  A 402 ( 3.7A)
None
CL  A 402 (-3.6A)
CL  A 405 (-4.0A)
CL  A 405 ( 4.9A)
CL  A 402 ( 4.1A)
 0.99A 4iv8B-1yb1A:
6.7		 4iv8B-1yb1A:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1yb1 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE
TYPE XI
(Homo
sapiens) 		4 / 8 GLU A  70
LEU A  58
LEU A  68
GLY A  44
 None
 0.88A 4r3aA-1yb1A:
undetectable		 4r3aA-1yb1A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 1yb1 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE
TYPE XI
(Homo
sapiens) 		6 / 12 GLY A  38
GLY A  40
ASP A  62
ILE A  63
ASN A  64
ILE A  43
 CL  A 402 ( 3.7A)
None
CL  A 402 (-3.6A)
CL  A 405 (-4.0A)
None
SO4  A 702 (-3.8A)
 0.86A 5wy0A-1yb1A:
5.2		 5wy0A-1yb1A:
22.73