SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yb2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 1yb2 HYPOTHETICAL PROTEIN
TA0852
(Thermoplasma
acidophilum) 		3 / 3 MET A 132
LEU A 135
SER A 136
 None
 0.36A 1ee2A-1yb2A:
8.3		 1ee2A-1yb2A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1yb2 HYPOTHETICAL PROTEIN
TA0852
(Thermoplasma
acidophilum) 		5 / 8 GLU A  96
GLY A  98
SER A 101
GLU A 122
ASP A 150
 None
 0.96A 1jg4A-1yb2A:
10.1		 1jg4A-1yb2A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 1yb2 HYPOTHETICAL PROTEIN
TA0852
(Thermoplasma
acidophilum) 		3 / 3 PHE A  18
LEU A  46
MET A 251
 None
 0.86A 1mx1D-1yb2A:
undetectable		 1mx1D-1yb2A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 1yb2 HYPOTHETICAL PROTEIN
TA0852
(Thermoplasma
acidophilum) 		6 / 12 GLU A  96
GLY A  98
GLY A 100
ASP A 124
ASP A 150
ILE A 151
 None
 0.90A 1qaoA-1yb2A:
11.9		 1qaoA-1yb2A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 1yb2 HYPOTHETICAL PROTEIN
TA0852
(Thermoplasma
acidophilum) 		3 / 3 GLY A  98
GLU A 122
ASP A 166
 None
 0.46A 2b25B-1yb2A:
15.9		 2b25B-1yb2A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1yb2 HYPOTHETICAL PROTEIN
TA0852
(Thermoplasma
acidophilum) 		5 / 10 GLN A 158
MET A 180
ILE A 177
VAL A  97
VAL A 121
 None
 1.26A 3fhjA-1yb2A:
2.0		 3fhjA-1yb2A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 1yb2 HYPOTHETICAL PROTEIN
TA0852
(Thermoplasma
acidophilum) 		6 / 12 VAL A  97
GLY A  98
GLY A 100
GLU A 122
ASP A 124
ASP A 150
 None
 0.73A 3fuuA-1yb2A:
11.4		 3fuuA-1yb2A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 1yb2 HYPOTHETICAL PROTEIN
TA0852
(Thermoplasma
acidophilum) 		5 / 11 GLY A  98
GLY A 100
GLU A 122
ASP A 124
ASP A 150
 None
 0.35A 3grvA-1yb2A:
13.7		 3grvA-1yb2A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 1yb2 HYPOTHETICAL PROTEIN
TA0852
(Thermoplasma
acidophilum) 		6 / 12 GLU A  96
GLY A  98
GLY A 100
GLU A 122
ASP A 124
ASP A 150
 None
 0.43A 3gryA-1yb2A:
13.8		 3gryA-1yb2A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1yb2 HYPOTHETICAL PROTEIN
TA0852
(Thermoplasma
acidophilum) 		5 / 11 GLY A  98
GLU A 122
ASP A 150
ASP A 166
ILE A 167
 None
 0.56A 3id5B-1yb2A:
15.1		 3id5B-1yb2A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1yb2 HYPOTHETICAL PROTEIN
TA0852
(Thermoplasma
acidophilum) 		5 / 11 GLY A  98
GLU A 122
ASP A 150
ASP A 166
ILE A 167
 None
 0.57A 3id5F-1yb2A:
15.0		 3id5F-1yb2A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1yb2 HYPOTHETICAL PROTEIN
TA0852
(Thermoplasma
acidophilum) 		5 / 12 GLY A  98
GLU A 122
ASP A 150
ASP A 166
ILE A 167
 None
 0.71A 3id6C-1yb2A:
15.1		 3id6C-1yb2A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1yb2 HYPOTHETICAL PROTEIN
TA0852
(Thermoplasma
acidophilum) 		4 / 4 GLY A  98
GLU A 122
ASP A 150
ASP A 166
 None
 0.57A 3mb5A-1yb2A:
19.5		 3mb5A-1yb2A:
29.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 1yb2 HYPOTHETICAL PROTEIN
TA0852
(Thermoplasma
acidophilum) 		4 / 7 ASP A  13
VAL A  48
ILE A  25
SER A  11
 None
 0.93A 3pglA-1yb2A:
3.1		 3pglA-1yb2A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 1yb2 HYPOTHETICAL PROTEIN
TA0852
(Thermoplasma
acidophilum) 		4 / 7 VAL A  66
ILE A  67
SER A  59
TYR A  62
 None
 0.97A 3pglA-1yb2A:
3.1		 3pglA-1yb2A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 1yb2 HYPOTHETICAL PROTEIN
TA0852
(Thermoplasma
acidophilum) 		4 / 6 HIS A 173
GLU A 122
ASP A 126
ASP A 150
 None
 1.25A 3vywA-1yb2A:
4.2		 3vywA-1yb2A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 1yb2 HYPOTHETICAL PROTEIN
TA0852
(Thermoplasma
acidophilum) 		3 / 3 GLU A 122
ASP A 124
ASP A 150
 None
 0.41A 4gc9A-1yb2A:
10.1		 4gc9A-1yb2A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 1yb2 HYPOTHETICAL PROTEIN
TA0852
(Thermoplasma
acidophilum) 		4 / 4 VAL A 215
THR A 214
GLU A 213
GLU A  12
 None
 1.31A 4l78A-1yb2A:
1.2		 4l78A-1yb2A:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 1yb2 HYPOTHETICAL PROTEIN
TA0852
(Thermoplasma
acidophilum) 		6 / 7 GLY A  98
GLY A 100
SER A 101
GLU A 122
ASP A 150
ASP A 166
 None
 0.81A 5ergB-1yb2A:
16.1		 5ergB-1yb2A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1yb2 HYPOTHETICAL PROTEIN
TA0852
(Thermoplasma
acidophilum) 		3 / 3 ALA A 131
ASN A 134
LEU A 135
 None
 0.47A 5i1nC-1yb2A:
undetectable		 5i1nC-1yb2A:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1yb2 HYPOTHETICAL PROTEIN
TA0852
(Thermoplasma
acidophilum) 		3 / 3 ALA A 131
ASN A 134
LEU A 135
 None
 0.49A 5i1pD-1yb2A:
undetectable		 5i1pD-1yb2A:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 1yb2 HYPOTHETICAL PROTEIN
TA0852
(Thermoplasma
acidophilum) 		3 / 3 ILE A 164
ILE A 167
MET A 104
 None
 0.67A 5i9yA-1yb2A:
undetectable		 5i9yA-1yb2A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 1yb2 HYPOTHETICAL PROTEIN
TA0852
(Thermoplasma
acidophilum) 		4 / 6 SER A 105
GLU A 122
ARG A 123
ASP A 150
 None
 0.78A 5zw4A-1yb2A:
14.3		 5zw4A-1yb2A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1yb2 HYPOTHETICAL PROTEIN
TA0852
(Thermoplasma
acidophilum) 		5 / 10 GLY A  98
GLY A 100
GLU A 122
ASP A 124
ILE A 151
 None
 1.21A 6exiA-1yb2A:
3.4		 6exiA-1yb2A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1yb2 HYPOTHETICAL PROTEIN
TA0852
(Thermoplasma
acidophilum) 		5 / 10 GLY A  98
GLY A 100
GLU A 122
ASP A 124
ILE A 151
 None
 1.20A 6exiB-1yb2A:
3.9		 6exiB-1yb2A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1yb2 HYPOTHETICAL PROTEIN
TA0852
(Thermoplasma
acidophilum) 		5 / 12 GLY A  98
GLY A 100
GLU A 122
ASP A 124
ILE A 151
 None
 1.19A 6exiC-1yb2A:
4.5
6exiD-1yb2A:
3.5		 6exiC-1yb2A:
16.17
6exiD-1yb2A:
16.17