SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yb3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FDU_B_ESTB354_1 (17-BETA-HYDROXYSTERO ID DEHYDROGENASE)	1yb3	HYPOTHETICAL PROTEIN (Pyrococcus furiosus)	4 / 8	SER A 37 VAL A 36 PRO A 58 VAL A 150	None	1.06A	1fduB-1yb3A: undetectable	1fduB-1yb3A: 18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MJQ_B_SAMB200_0 (METHIONINE REPRESSOR)	1yb3	HYPOTHETICAL PROTEIN (Pyrococcus furiosus)	5 / 11	GLU A 134 PHE A 139 GLY A 105 LEU A 166 GLU A 85	None	1.43A	1mjqA-1yb3A: undetectable 1mjqB-1yb3A: undetectable	1mjqA-1yb3A: 20.22 1mjqB-1yb3A: 20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MB5_A_SAMA301_1 (SAM-DEPENDENT METHYLTRANSFERASE)	1yb3	HYPOTHETICAL PROTEIN (Pyrococcus furiosus)	4 / 4	GLY A 48 GLU A 117 ASP A 112 ASP A 47	None	1.33A	3mb5A-1yb3A: undetectable	3mb5A-1yb3A: 23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PD9_A_ADNA501_1 (NUPC FAMILY PROTEIN)	1yb3	HYPOTHETICAL PROTEIN (Pyrococcus furiosus)	5 / 12	GLY A 69 ALA A 59 VAL A 39 GLU A 38 ILE A 13	None	1.23A	4pd9A-1yb3A: undetectable	4pd9A-1yb3A: 17.34

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1FDU_B_ESTB354_1","17-BETA-HYDROXYSTEROID DEHYDROGENASE","1yb3","HYPOTHETICAL PROTEIN","Pyrococcus furiosus",4,"SER A  37;VAL A  36;PRO A  58;VAL A 150","None","1.06A","1fduB-1yb3A:undetectable","1fduB-1yb3A:18.40"],["1MJQ_B_SAMB200_0","METHIONINE REPRESSOR","1yb3","HYPOTHETICAL PROTEIN","Pyrococcus furiosus",5,"GLU A 134;PHE A 139;GLY A 105;LEU A 166;GLU A  85","None","1.43A","1mjqA-1yb3A:undetectable;1mjqB-1yb3A:undetectable","1mjqA-1yb3A:20.22;1mjqB-1yb3A:20.22"],["3MB5_A_SAMA301_1","SAM-DEPENDENT METHYLTRANSFERASE","1yb3","HYPOTHETICAL PROTEIN","Pyrococcus furiosus",4,"GLY A  48;GLU A 117;ASP A 112;ASP A  47","None","1.33A","3mb5A-1yb3A:undetectable","3mb5A-1yb3A:23.77"],["4PD9_A_ADNA501_1","NUPC FAMILY PROTEIN","1yb3","HYPOTHETICAL PROTEIN","Pyrococcus furiosus",5,"GLY A  69;ALA A  59;VAL A  39;GLU A  38;ILE A  13","None","1.23A","4pd9A-1yb3A:undetectable","4pd9A-1yb3A:17.34"]]