SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yb4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE
(Salmonella
enterica) 		3 / 3 THR A 256
PRO A 254
THR A 258
 None
 0.81A 209dC-1yb4A:
undetectable		 209dC-1yb4A:
3.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE
(Salmonella
enterica) 		4 / 8 VAL A 170
ASN A 172
ALA A 177
GLN A 260
 None
 0.99A 2ij7C-1yb4A:
undetectable		 2ij7C-1yb4A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE
(Salmonella
enterica) 		4 / 8 ASP A 116
LYS A 101
SER A 245
ASP A 164
 None
 1.03A 2p02A-1yb4A:
undetectable		 2p02A-1yb4A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE
(Salmonella
enterica) 		5 / 10 ILE A  58
ALA A  56
PHE A   5
PHE A  60
LEU A 152
 None
 1.21A 2w3aB-1yb4A:
undetectable		 2w3aB-1yb4A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE
(Salmonella
enterica) 		5 / 12 VAL A  69
ILE A  95
PHE A 149
GLN A 166
PHE A  60
 None
 1.38A 3apwB-1yb4A:
undetectable		 3apwB-1yb4A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE
(Salmonella
enterica) 		4 / 4 GLY A 163
GLY A 136
GLY A 160
GLY A 165
 None
 0.57A 3bogC-1yb4A:
0.0		 3bogC-1yb4A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE
(Salmonella
enterica) 		4 / 4 GLY A 163
GLY A 136
GLY A 160
GLY A 165
 None
 0.54A 3bogD-1yb4A:
undetectable		 3bogD-1yb4A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE
(Salmonella
enterica) 		4 / 6 HIS A  24
VAL A  28
LEU A 131
LEU A   8
 None
 0.99A 3kk6A-1yb4A:
undetectable		 3kk6A-1yb4A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE
(Salmonella
enterica) 		5 / 6 VAL A  34
LEU A 152
ILE A  59
ALA A  16
LEU A  38
 None
 1.41A 3kk6B-1yb4A:
undetectable		 3kk6B-1yb4A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE
(Salmonella
enterica) 		4 / 8 PHE A  60
GLY A   4
PHE A   5
ILE A 151
 None
 0.93A 3ko0O-1yb4A:
undetectable
3ko0Q-1yb4A:
undetectable		 3ko0O-1yb4A:
18.12
3ko0Q-1yb4A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE
(Salmonella
enterica) 		5 / 11 LEU A 241
ALA A 171
ILE A 175
THR A 100
PRO A 118
 None
 1.48A 3qelA-1yb4A:
5.4
3qelB-1yb4A:
5.7		 3qelA-1yb4A:
23.04
3qelB-1yb4A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE
(Salmonella
enterica) 		5 / 10 VAL A  69
ALA A 104
ARG A 106
VAL A 107
ILE A  89
 None
 1.43A 3retA-1yb4A:
undetectable
3retB-1yb4A:
undetectable		 3retA-1yb4A:
15.33
3retB-1yb4A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_B_SALB201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE
(Salmonella
enterica) 		5 / 9 VAL A  69
ALA A 104
ARG A 106
VAL A 107
ILE A  89
 None
 1.43A 3retB-1yb4A:
undetectable		 3retB-1yb4A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE
(Salmonella
enterica) 		4 / 8 ASP A  71
GLY A  75
PRO A  67
ARG A 106
 None
 0.94A 3s3nA-1yb4A:
undetectable		 3s3nA-1yb4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE
(Salmonella
enterica) 		4 / 8 GLY A 111
ALA A 112
ASP A 113
THR A  53
 None
 0.57A 3so9A-1yb4A:
undetectable		 3so9A-1yb4A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE
(Salmonella
enterica) 		5 / 12 ASP A 238
HIS A 217
ASP A 275
HIS A 276
GLY A 229
 None
 1.33A 4bz6A-1yb4A:
undetectable
4bz6B-1yb4A:
undetectable		 4bz6A-1yb4A:
21.51
4bz6B-1yb4A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE
(Salmonella
enterica) 		4 / 7 ALA A  43
VAL A  46
ILE A  58
THR A  30
 None
 0.77A 4eyrA-1yb4A:
undetectable		 4eyrA-1yb4A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE
(Salmonella
enterica) 		4 / 8 ASP A 116
LYS A 101
SER A 245
ASP A 164
 None
 1.13A 4kttA-1yb4A:
undetectable		 4kttA-1yb4A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE
(Salmonella
enterica) 		4 / 8 ASP A 116
LYS A 101
SER A 245
ASP A 164
 None
 1.07A 4kttC-1yb4A:
undetectable		 4kttC-1yb4A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE
(Salmonella
enterica) 		4 / 8 ASP A 116
LYS A 101
SER A 245
ASP A 164
 None
 1.08A 4ndnA-1yb4A:
undetectable		 4ndnA-1yb4A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE
(Salmonella
enterica) 		4 / 7 ASP A 116
LYS A 101
SER A 245
ASP A 164
 None
 1.08A 4ndnC-1yb4A:
undetectable		 4ndnC-1yb4A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE
(Salmonella
enterica) 		4 / 7 ASP A 116
LYS A 101
SER A 245
ASP A 164
 None
 1.07A 4odjA-1yb4A:
undetectable		 4odjA-1yb4A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE
(Salmonella
enterica) 		4 / 5 ASP A 116
LEU A 115
ARG A 144
THR A 100
 None
 1.46A 4p3qA-1yb4A:
undetectable		 4p3qA-1yb4A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE
(Salmonella
enterica) 		4 / 8 ASP A 116
LYS A 101
SER A 245
ASP A 164
 None
 0.99A 5a1iA-1yb4A:
undetectable		 5a1iA-1yb4A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE
(Salmonella
enterica) 		4 / 7 ASP A 116
LYS A 101
SER A 245
ASP A 164
 None
 0.99A 5a1iA-1yb4A:
undetectable		 5a1iA-1yb4A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE
(Salmonella
enterica) 		4 / 8 ASP A 116
LYS A 101
SER A 245
ASP A 164
 None
 1.02A 6fbnB-1yb4A:
undetectable		 6fbnB-1yb4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE
(Salmonella
enterica) 		4 / 8 ASP A 116
LYS A 101
SER A 245
ASP A 164
 None
 0.97A 6fboA-1yb4A:
undetectable		 6fboA-1yb4A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE
(Salmonella
enterica) 		4 / 8 ASP A 116
LYS A 101
SER A 245
ASP A 164
 None
 1.03A 6fcbA-1yb4A:
undetectable		 6fcbA-1yb4A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE
(Salmonella
enterica) 		4 / 8 ASP A 116
SER A  96
SER A 245
ASP A 164
 None
 1.22A 6fcbA-1yb4A:
undetectable		 6fcbA-1yb4A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE
(Salmonella
enterica) 		4 / 8 ASP A 116
LYS A 101
SER A 245
ASP A 164
 None
 1.01A 6fcdA-1yb4A:
undetectable		 6fcdA-1yb4A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE
(Salmonella
enterica) 		4 / 7 ASP A 116
LYS A 101
SER A 245
ASP A 164
 None
 0.99A 6g6rA-1yb4A:
undetectable		 6g6rA-1yb4A:
22.08