SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yb5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		5 / 12 ALA A 283
PHE A 279
TYR A 133
GLY A 130
ILE A 129
 None
 1.23A 1kglA-1yb5A:
undetectable		 1kglA-1yb5A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		3 / 3 ARG A  12
VAL A  73
THR A  98
 None
 0.62A 2nmzA-1yb5A:
undetectable		 2nmzA-1yb5A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		3 / 3 ARG A  12
VAL A  73
THR A  98
 None
 0.63A 2nnkA-1yb5A:
undetectable		 2nnkA-1yb5A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		5 / 12 GLY A  46
GLY A 323
GLY A 160
ILE A 188
VAL A 298
 None
None
NAP  A 801 ( 3.9A)
None
None
 0.73A 2oxtB-1yb5A:
5.0		 2oxtB-1yb5A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		5 / 12 GLY A 156
GLY A 162
ILE A 218
LEU A 177
GLY A 178
 NAP  A 801 ( 3.1A)
CL  A 816 (-3.3A)
None
None
None
 0.90A 3axzA-1yb5A:
undetectable		 3axzA-1yb5A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		3 / 3 SER A 158
GLY A 181
GLY A 320
 NAP  A 801 (-2.7A)
NAP  A 801 (-3.5A)
NAP  A 801 ( 3.3A)
 0.55A 3bogA-1yb5A:
undetectable
3bogC-1yb5A:
undetectable		 3bogA-1yb5A:
undetectable
3bogC-1yb5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		5 / 11 LEU A 140
ALA A 164
ALA A 165
VAL A 146
MET A 224
 None
None
None
None
NAP  A 801 ( 4.0A)
 1.28A 3bszE-1yb5A:
undetectable		 3bszE-1yb5A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		3 / 3 ILE A 221
SER A 235
SER A 231
 None
 0.60A 3iltH-1yb5A:
undetectable		 3iltH-1yb5A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		3 / 3 ARG A  12
VAL A  73
THR A  98
 None
 0.66A 3k4vA-1yb5A:
undetectable		 3k4vA-1yb5A:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		3 / 3 ARG A  12
VAL A  73
THR A  98
 None
 0.72A 3k4vD-1yb5A:
undetectable		 3k4vD-1yb5A:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		4 / 6 LEU A 305
GLU A 306
PRO A 304
ARG A   9
 None
 1.19A 3ltwA-1yb5A:
undetectable		 3ltwA-1yb5A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		5 / 12 GLY A 160
GLY A 323
ALA A 165
ALA A 136
SER A 301
 NAP  A 801 ( 3.9A)
None
None
None
GOL  A 820 (-2.8A)
 1.16A 3mteA-1yb5A:
4.2		 3mteA-1yb5A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		3 / 3 ARG A  12
VAL A  73
THR A  98
 None
 0.56A 3ndtA-1yb5A:
undetectable		 3ndtA-1yb5A:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		3 / 3 ARG A  12
VAL A  73
THR A  98
 None
 0.72A 3nduD-1yb5A:
undetectable		 3nduD-1yb5A:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		5 / 12 GLY A 160
GLY A 323
VAL A 189
ALA A 165
SER A 301
 NAP  A 801 ( 3.9A)
None
None
None
GOL  A 820 (-2.8A)
 1.00A 3p2kD-1yb5A:
undetectable		 3p2kD-1yb5A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		3 / 3 ARG A  12
VAL A  73
THR A  98
 None
 0.58A 3pwrA-1yb5A:
undetectable		 3pwrA-1yb5A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		3 / 3 ARG A  12
VAL A  73
THR A  98
 None
 0.66A 3tl9A-1yb5A:
undetectable		 3tl9A-1yb5A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		3 / 3 SER A  85
PHE A  87
LYS A  88
 GOL  A 815 (-4.0A)
None
None
 0.69A 3u88A-1yb5A:
undetectable		 3u88A-1yb5A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		5 / 9 GLY A 159
ALA A 165
GLY A 162
VAL A 189
CYH A 166
 CL  A 816 ( 3.1A)
None
CL  A 816 (-3.3A)
None
None
 1.46A 4c5lB-1yb5A:
4.0		 4c5lB-1yb5A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		5 / 10 GLY A 159
GLY A 162
HIS A 155
VAL A 189
CYH A 166
 CL  A 816 ( 3.1A)
CL  A 816 (-3.3A)
NAP  A 801 (-4.4A)
None
None
 1.30A 4c5nB-1yb5A:
4.5		 4c5nB-1yb5A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		5 / 10 GLY A 159
ALA A 165
GLY A 162
VAL A 189
CYH A 166
 CL  A 816 ( 3.1A)
None
CL  A 816 (-3.3A)
None
None
 1.41A 4c5nD-1yb5A:
3.9		 4c5nD-1yb5A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		5 / 12 GLU A 223
ILE A 221
LEU A 140
LEU A 177
GLY A 178
 NAP  A 801 ( 4.9A)
None
None
None
None
 1.22A 4foxG-1yb5A:
0.0		 4foxG-1yb5A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		5 / 12 GLY A 320
GLY A 318
ILE A 188
GLY A 159
LEU A 163
 NAP  A 801 ( 3.3A)
GOL  A 820 ( 3.8A)
None
CL  A 816 ( 3.1A)
None
 1.27A 4n48A-1yb5A:
6.8		 4n48A-1yb5A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		5 / 12 LEU A 163
GLY A 162
THR A 135
MET A 224
VAL A 269
 None
CL  A 816 (-3.3A)
NAP  A 801 (-3.0A)
NAP  A 801 ( 4.0A)
NAP  A 801 (-4.7A)
 1.45A 4okxA-1yb5A:
undetectable		 4okxA-1yb5A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		4 / 6 ASP A 233
LEU A 236
HIS A 155
THR A 179
 None
None
NAP  A 801 (-4.4A)
None
 1.34A 4paeA-1yb5A:
undetectable		 4paeA-1yb5A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		5 / 11 LEU A 117
PHE A  94
ASP A  72
ALA A  74
THR A 113
 None
None
None
None
CL  A 818 (-3.2A)
 1.26A 4uuuB-1yb5A:
undetectable		 4uuuB-1yb5A:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		3 / 3 GLU A 150
ILE A 244
ALA A 169
 None
 0.63A 4wnwB-1yb5A:
undetectable		 4wnwB-1yb5A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		4 / 9 SER A  97
GLU A  51
LEU A 271
ILE A 129
 CL  A 818 (-4.7A)
None
NAP  A 801 (-4.8A)
None
 0.99A 4xtaA-1yb5A:
undetectable		 4xtaA-1yb5A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		4 / 6 HIS A 155
GLY A 156
GLU A 223
ASN A 229
 NAP  A 801 (-4.4A)
NAP  A 801 ( 3.1A)
NAP  A 801 ( 4.9A)
NAP  A 801 (-3.3A)
 1.24A 4zbqA-1yb5A:
undetectable		 4zbqA-1yb5A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		4 / 8 THR A 113
THR A  95
PRO A  33
ILE A  99
 CL  A 818 (-3.2A)
None
None
CL  A 818 ( 4.9A)
 1.12A 5jhdE-1yb5A:
undetectable
5jhdG-1yb5A:
undetectable		 5jhdE-1yb5A:
24.72
5jhdG-1yb5A:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		5 / 12 GLY A 156
GLY A 162
VAL A 152
LEU A 177
GLY A 178
 NAP  A 801 ( 3.1A)
CL  A 816 (-3.3A)
None
None
None
 1.07A 5wyqA-1yb5A:
undetectable		 5wyqA-1yb5A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		5 / 12 GLY A 159
ILE A 131
VAL A  47
GLY A 160
PRO A 132
 CL  A 816 ( 3.1A)
NAP  A 801 (-4.5A)
None
NAP  A 801 ( 3.9A)
None
 0.98A 5wyqA-1yb5A:
undetectable		 5wyqA-1yb5A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		3 / 3 GLN A 302
ILE A 316
HIS A 317
 None
 0.69A 5z12B-1yb5A:
undetectable		 5z12B-1yb5A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens) 		5 / 12 GLY A 156
GLY A 162
ILE A 218
LEU A 177
GLY A 178
 NAP  A 801 ( 3.1A)
CL  A 816 (-3.3A)
None
None
None
 0.86A 5zhmB-1yb5A:
undetectable		 5zhmB-1yb5A:
27.84