SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ybd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1ybd URIDYLATE KINASE
(Neisseria
meningitidis) 		4 / 7 GLY A  23
ALA A 221
THR A  37
THR A  33
 None
 0.89A 1c9sT-1ybdA:
undetectable
1c9sU-1ybdA:
undetectable		 1c9sT-1ybdA:
16.53
1c9sU-1ybdA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 1ybd URIDYLATE KINASE
(Neisseria
meningitidis) 		5 / 9 LEU A  21
ILE A  34
LEU A  14
GLY A  39
ALA A  94
 None
 1.17A 1e7aA-1ybdA:
undetectable		 1e7aA-1ybdA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1ybd URIDYLATE KINASE
(Neisseria
meningitidis) 		4 / 7 GLY A  23
ALA A 221
THR A  37
THR A  33
 None
 0.90A 1gtfL-1ybdA:
undetectable
1gtfM-1ybdA:
undetectable		 1gtfL-1ybdA:
16.53
1gtfM-1ybdA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1ybd URIDYLATE KINASE
(Neisseria
meningitidis) 		4 / 8 GLY A  23
ALA A 221
THR A  37
THR A  33
 None
 0.89A 1gtfN-1ybdA:
undetectable
1gtfO-1ybdA:
undetectable		 1gtfN-1ybdA:
16.53
1gtfO-1ybdA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 1ybd URIDYLATE KINASE
(Neisseria
meningitidis) 		3 / 3 ARG A 103
TYR A 125
LYS A 121
 None
 0.92A 1uujB-1ybdA:
undetectable		 1uujB-1ybdA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ybd URIDYLATE KINASE
(Neisseria
meningitidis) 		4 / 8 LEU A  21
LEU A 226
VAL A  51
GLY A  52
 None
 0.96A 2po5B-1ybdA:
3.1		 2po5B-1ybdA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 1ybd URIDYLATE KINASE
(Neisseria
meningitidis) 		5 / 12 LEU A  13
ASP A 146
MET A 156
THR A 138
GLY A 137
 None
GOL  A 250 ( 4.4A)
None
None
None
 1.18A 2uvnA-1ybdA:
undetectable		 2uvnA-1ybdA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1ybd URIDYLATE KINASE
(Neisseria
meningitidis) 		5 / 12 ILE A 220
PHE A  95
VAL A 104
ILE A 133
THR A  84
 None
 1.37A 3em0B-1ybdA:
undetectable		 3em0B-1ybdA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1ybd URIDYLATE KINASE
(Neisseria
meningitidis) 		5 / 12 VAL A  51
ILE A 220
SER A  20
LEU A  21
ILE A  53
 None
 1.15A 3qfxA-1ybdA:
undetectable		 3qfxA-1ybdA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1ybd URIDYLATE KINASE
(Neisseria
meningitidis) 		5 / 12 VAL A  51
ILE A 220
SER A  20
LEU A  21
ILE A  53
 None
 1.16A 3qfxB-1ybdA:
2.6		 3qfxB-1ybdA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1ybd URIDYLATE KINASE
(Neisseria
meningitidis) 		5 / 12 VAL A  55
VAL A  45
ILE A 220
LEU A 226
VAL A  44
 None
 1.22A 3w68C-1ybdA:
undetectable		 3w68C-1ybdA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 1ybd URIDYLATE KINASE
(Neisseria
meningitidis) 		4 / 7 MET A 161
LYS A 163
THR A 237
VAL A 239
 None
GOL  A 250 ( 4.2A)
None
None
 0.78A 4ik7A-1ybdA:
undetectable		 4ik7A-1ybdA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1ybd URIDYLATE KINASE
(Neisseria
meningitidis) 		4 / 8 LEU A 162
VAL A 239
LEU A 238
GLY A 232
 None
 0.89A 4r3aA-1ybdA:
undetectable		 4r3aA-1ybdA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 1ybd URIDYLATE KINASE
(Neisseria
meningitidis) 		5 / 9 SER A  65
GLY A  56
SER A  17
GLU A  19
ALA A 148
 None
GOL  A 250 ( 4.1A)
GOL  A 250 (-4.2A)
GOL  A 250 ( 3.7A)
None
 1.28A 5entC-1ybdA:
0.6		 5entC-1ybdA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1ybd URIDYLATE KINASE
(Neisseria
meningitidis) 		5 / 8 VAL A 131
ILE A 100
ALA A  42
VAL A  49
VAL A  51
 None
 1.45A 5l94A-1ybdA:
undetectable		 5l94A-1ybdA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1ybd URIDYLATE KINASE
(Neisseria
meningitidis) 		4 / 7 THR A 237
ARG A 183
PHE A 218
LEU A 162
 None
 1.17A 5uxcA-1ybdA:
undetectable		 5uxcA-1ybdA:
23.53