SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ybe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Agrobacterium
tumefaciens) 		6 / 12 PRO A 150
THR A 374
GLY A 370
ASN A 375
ILE A 393
LEU A  58
 None
 1.50A 1r30A-1ybeA:
2.9		 1r30A-1ybeA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Agrobacterium
tumefaciens) 		6 / 12 PRO A 150
THR A 374
GLY A 370
ASN A 375
ILE A 393
LEU A  58
 None
 1.50A 1r30B-1ybeA:
2.9		 1r30B-1ybeA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Agrobacterium
tumefaciens) 		4 / 7 PHE A 201
ARG A 204
ASP A  35
TYR A  37
 None
 1.14A 2e5dA-1ybeA:
5.4
2e5dB-1ybeA:
9.4		 2e5dA-1ybeA:
23.76
2e5dB-1ybeA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Agrobacterium
tumefaciens) 		4 / 7 ASP A  35
TYR A  37
PHE A 201
ARG A 204
 None
 1.14A 2e5dA-1ybeA:
5.5
2e5dB-1ybeA:
9.4		 2e5dA-1ybeA:
23.76
2e5dB-1ybeA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Agrobacterium
tumefaciens) 		5 / 8 GLY A 430
GLY A 293
THR A 294
ALA A 295
ALA A 296
 None
 1.40A 2ej3C-1ybeA:
undetectable		 2ej3C-1ybeA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Agrobacterium
tumefaciens) 		5 / 6 PHE A 201
ARG A 204
SER A 231
GLY A 245
THR A 246
 None
 1.06A 2f7fA-1ybeA:
6.0		 2f7fA-1ybeA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Agrobacterium
tumefaciens) 		5 / 6 PHE A 201
SER A 231
GLY A 245
THR A 246
ARG A 312
 None
 1.03A 2f7fA-1ybeA:
6.0		 2f7fA-1ybeA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HCJ_B_TACB888_1
(PROTEIN CHAIN
ELONGATION FACTOR
EF-TU)		 1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Agrobacterium
tumefaciens) 		4 / 4 THR A 294
SER A 315
ASP A 410
PRO A 313
 None
 1.47A 2hcjA-1ybeA:
0.0
2hcjB-1ybeA:
1.0		 2hcjA-1ybeA:
6.83
2hcjB-1ybeA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Agrobacterium
tumefaciens) 		4 / 5 THR A 294
SER A 315
ASP A 410
PRO A 313
 None
 1.44A 2hdnA-1ybeA:
undetectable
2hdnB-1ybeA:
undetectable
2hdnD-1ybeA:
undetectable		 2hdnA-1ybeA:
6.83
2hdnB-1ybeA:
21.98
2hdnD-1ybeA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Agrobacterium
tumefaciens) 		4 / 5 THR A 294
SER A 315
ASP A 410
PRO A 313
 None
 1.45A 2hdnB-1ybeA:
undetectable
2hdnC-1ybeA:
undetectable
2hdnD-1ybeA:
undetectable		 2hdnB-1ybeA:
21.98
2hdnC-1ybeA:
6.83
2hdnD-1ybeA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Agrobacterium
tumefaciens) 		5 / 8 SER A 199
GLN A 212
SER A 231
GLY A 370
GLY A 368
 None
 1.31A 2vinA-1ybeA:
undetectable		 2vinA-1ybeA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Agrobacterium
tumefaciens) 		4 / 8 PHE A 367
GLY A 368
PRO A 318
GLY A 322
 None
 0.83A 2y6rB-1ybeA:
undetectable		 2y6rB-1ybeA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Agrobacterium
tumefaciens) 		4 / 4 VAL A 216
ARG A  29
ILE A  32
THR A 374
 None
 1.30A 3cl9A-1ybeA:
undetectable		 3cl9A-1ybeA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Agrobacterium
tumefaciens) 		5 / 12 VAL A 244
LEU A 196
PHE A 227
GLY A 202
LEU A 373
 None
 1.31A 3j6pB-1ybeA:
undetectable		 3j6pB-1ybeA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Agrobacterium
tumefaciens) 		4 / 8 VAL A 187
VAL A 349
TRP A 184
GLU A 188
 None
 1.08A 3nlqA-1ybeA:
undetectable
3nlqB-1ybeA:
undetectable		 3nlqA-1ybeA:
20.77
3nlqB-1ybeA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Agrobacterium
tumefaciens) 		5 / 12 LEU A 196
GLY A 370
LEU A 373
PHE A 201
SER A 199
 None
 1.25A 3tbgA-1ybeA:
undetectable		 3tbgA-1ybeA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Agrobacterium
tumefaciens) 		5 / 12 PHE A 209
GLY A 229
ASP A 238
SER A 239
PHE A 101
 None
 1.27A 3tbgA-1ybeA:
undetectable		 3tbgA-1ybeA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Agrobacterium
tumefaciens) 		5 / 12 LEU A 196
GLY A 370
LEU A 373
PHE A 201
SER A 199
 None
 1.25A 3tbgC-1ybeA:
undetectable		 3tbgC-1ybeA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Agrobacterium
tumefaciens) 		3 / 3 ARG A  29
ARG A 161
ASP A  12
 None
 0.95A 3wipG-1ybeA:
undetectable
3wipH-1ybeA:
undetectable		 3wipG-1ybeA:
20.04
3wipH-1ybeA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Agrobacterium
tumefaciens) 		3 / 3 ASN A 136
LEU A  80
PHE A  56
 None
 0.79A 4dajB-1ybeA:
undetectable		 4dajB-1ybeA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Agrobacterium
tumefaciens) 		5 / 11 HIS A 207
SER A 208
LEU A 241
LEU A 373
GLY A 202
 None
 1.30A 4foxC-1ybeA:
0.0		 4foxC-1ybeA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Agrobacterium
tumefaciens) 		3 / 3 ASP A 290
ASN A 411
SER A 344
 None
 0.80A 4obwA-1ybeA:
undetectable		 4obwA-1ybeA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Agrobacterium
tumefaciens) 		3 / 3 ASP A  33
ARG A  16
ARG A 161
 None
 0.77A 4x5iA-1ybeA:
undetectable		 4x5iA-1ybeA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Agrobacterium
tumefaciens) 		4 / 6 TYR A  37
LYS A  38
LEU A 251
GLU A 250
 None
 1.03A 4z4cA-1ybeA:
undetectable		 4z4cA-1ybeA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Agrobacterium
tumefaciens) 		4 / 5 TYR A  37
LYS A  38
LEU A 251
GLU A 250
 None
 1.19A 4z4dA-1ybeA:
0.6		 4z4dA-1ybeA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Agrobacterium
tumefaciens) 		4 / 5 TYR A  37
LYS A  38
LEU A 251
GLU A 250
 None
 1.13A 4z4hA-1ybeA:
0.0		 4z4hA-1ybeA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Agrobacterium
tumefaciens) 		4 / 6 LEU A 279
LEU A  48
LEU A 258
GLU A 250
 None
 0.90A 5tudD-1ybeA:
undetectable		 5tudD-1ybeA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Agrobacterium
tumefaciens) 		3 / 3 SER A 160
HIS A 207
TYR A 176
 None
 0.86A 5y2tA-1ybeA:
undetectable		 5y2tA-1ybeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Agrobacterium
tumefaciens) 		5 / 12 PHE A 429
VAL A 305
PHE A 311
THR A 294
GLY A 293
 None
 1.09A 6brdA-1ybeA:
undetectable		 6brdA-1ybeA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Agrobacterium
tumefaciens) 		5 / 12 PHE A 429
VAL A 305
PHE A 311
THR A 294
GLY A 293
 None
 1.06A 6brdB-1ybeA:
undetectable		 6brdB-1ybeA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Agrobacterium
tumefaciens) 		4 / 5 TYR A  37
LYS A  38
LEU A 251
GLU A 250
 None
 1.22A 6cbdA-1ybeA:
0.0		 6cbdA-1ybeA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Agrobacterium
tumefaciens) 		4 / 6 PRO A 317
ILE A 319
GLY A 321
GLU A 323
 None
 1.12A 6gqiA-1ybeA:
undetectable		 6gqiA-1ybeA:
21.70