SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ybi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 1ybi NON-TOXIN
HAEMAGGLUTININ HA34
(Clostridium
botulinum) 		3 / 3 ASN A 210
TYR A 237
SER A 226
 None
 0.84A 2gvcB-1ybiA:
undetectable		 2gvcB-1ybiA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 1ybi NON-TOXIN
HAEMAGGLUTININ HA34
(Clostridium
botulinum) 		3 / 3 ASN A 210
TYR A 237
SER A 226
 None
 0.80A 2gvcE-1ybiA:
undetectable		 2gvcE-1ybiA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 1ybi NON-TOXIN
HAEMAGGLUTININ HA34
(Clostridium
botulinum) 		4 / 6 ASP A  23
TYR A 119
PHE A  28
LEU A 127
 None
 1.19A 2w98A-1ybiA:
undetectable
2w98B-1ybiA:
undetectable		 2w98A-1ybiA:
21.45
2w98B-1ybiA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 1ybi NON-TOXIN
HAEMAGGLUTININ HA34
(Clostridium
botulinum) 		5 / 12 ILE A 146
ILE A 240
ILE A 290
GLU A 248
PRO A 242
 None
 1.25A 2yzqA-1ybiA:
undetectable		 2yzqA-1ybiA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ybi NON-TOXIN
HAEMAGGLUTININ HA34
(Clostridium
botulinum) 		4 / 4 ILE A  61
GLN A  30
ILE A  51
LEU A  45
 None
 1.31A 3dzyD-1ybiA:
undetectable		 3dzyD-1ybiA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 1ybi NON-TOXIN
HAEMAGGLUTININ HA34
(Clostridium
botulinum) 		5 / 12 LEU A 129
ILE A  82
ASP A 121
PHE A 140
SER A 135
 None
 1.27A 3ko0A-1ybiA:
undetectable
3ko0B-1ybiA:
undetectable
3ko0C-1ybiA:
undetectable
3ko0D-1ybiA:
undetectable		 3ko0A-1ybiA:
14.58
3ko0B-1ybiA:
14.58
3ko0C-1ybiA:
14.58
3ko0D-1ybiA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 1ybi NON-TOXIN
HAEMAGGLUTININ HA34
(Clostridium
botulinum) 		5 / 11 PHE A 140
SER A 135
LEU A 129
ILE A  82
ASP A 121
 None
 1.31A 3ko0A-1ybiA:
undetectable
3ko0B-1ybiA:
undetectable
3ko0C-1ybiA:
undetectable
3ko0D-1ybiA:
undetectable		 3ko0A-1ybiA:
14.58
3ko0B-1ybiA:
14.58
3ko0C-1ybiA:
14.58
3ko0D-1ybiA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 1ybi NON-TOXIN
HAEMAGGLUTININ HA34
(Clostridium
botulinum) 		5 / 11 ASP A 121
LEU A 129
ILE A  82
PHE A 140
SER A 135
 None
 1.31A 3ko0C-1ybiA:
undetectable
3ko0D-1ybiA:
undetectable
3ko0E-1ybiA:
undetectable
3ko0F-1ybiA:
undetectable		 3ko0C-1ybiA:
14.58
3ko0D-1ybiA:
14.58
3ko0E-1ybiA:
14.58
3ko0F-1ybiA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)		 1ybi NON-TOXIN
HAEMAGGLUTININ HA34
(Clostridium
botulinum) 		5 / 11 SER A 135
PHE A 140
LEU A 129
ILE A  82
ASP A 121
 None
 1.27A 3ko0C-1ybiA:
undetectable
3ko0D-1ybiA:
undetectable
3ko0E-1ybiA:
undetectable
3ko0F-1ybiA:
undetectable		 3ko0C-1ybiA:
14.58
3ko0D-1ybiA:
14.58
3ko0E-1ybiA:
14.58
3ko0F-1ybiA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 1ybi NON-TOXIN
HAEMAGGLUTININ HA34
(Clostridium
botulinum) 		5 / 11 ASP A 121
LEU A 129
ILE A  82
PHE A 140
SER A 135
 None
 1.32A 3ko0E-1ybiA:
undetectable
3ko0F-1ybiA:
undetectable
3ko0G-1ybiA:
undetectable
3ko0H-1ybiA:
undetectable		 3ko0E-1ybiA:
14.58
3ko0F-1ybiA:
14.58
3ko0G-1ybiA:
14.58
3ko0H-1ybiA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 1ybi NON-TOXIN
HAEMAGGLUTININ HA34
(Clostridium
botulinum) 		5 / 12 ASP A 121
LEU A 129
ILE A  82
PHE A 140
SER A 135
 None
 1.32A 3ko0G-1ybiA:
undetectable
3ko0H-1ybiA:
undetectable
3ko0I-1ybiA:
undetectable
3ko0J-1ybiA:
undetectable		 3ko0G-1ybiA:
14.58
3ko0H-1ybiA:
14.58
3ko0I-1ybiA:
14.58
3ko0J-1ybiA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN202_1
(PROTEIN S100-A4)		 1ybi NON-TOXIN
HAEMAGGLUTININ HA34
(Clostridium
botulinum) 		5 / 11 SER A 135
PHE A 140
ASP A 121
LEU A 129
ILE A  82
 None
 1.33A 3ko0K-1ybiA:
undetectable
3ko0L-1ybiA:
undetectable
3ko0M-1ybiA:
undetectable
3ko0N-1ybiA:
undetectable		 3ko0K-1ybiA:
14.58
3ko0L-1ybiA:
14.58
3ko0M-1ybiA:
14.58
3ko0N-1ybiA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 1ybi NON-TOXIN
HAEMAGGLUTININ HA34
(Clostridium
botulinum) 		5 / 11 LEU A 129
ILE A  82
ASP A 121
PHE A 140
SER A 135
 None
 1.31A 3ko0O-1ybiA:
undetectable
3ko0P-1ybiA:
undetectable
3ko0Q-1ybiA:
undetectable
3ko0R-1ybiA:
undetectable		 3ko0O-1ybiA:
14.58
3ko0P-1ybiA:
14.58
3ko0Q-1ybiA:
14.58
3ko0R-1ybiA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ202_1
(PROTEIN S100-A4)		 1ybi NON-TOXIN
HAEMAGGLUTININ HA34
(Clostridium
botulinum) 		5 / 10 PHE A 140
SER A 135
LEU A 129
ILE A  82
ASP A 121
 None
 1.30A 3ko0O-1ybiA:
undetectable
3ko0P-1ybiA:
undetectable
3ko0Q-1ybiA:
undetectable
3ko0R-1ybiA:
undetectable		 3ko0O-1ybiA:
14.58
3ko0P-1ybiA:
14.58
3ko0Q-1ybiA:
14.58
3ko0R-1ybiA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 1ybi NON-TOXIN
HAEMAGGLUTININ HA34
(Clostridium
botulinum) 		5 / 11 SER A 135
PHE A 140
ASP A 121
LEU A 129
ILE A  82
 None
 1.29A 3ko0Q-1ybiA:
undetectable
3ko0R-1ybiA:
undetectable
3ko0S-1ybiA:
undetectable
3ko0T-1ybiA:
undetectable		 3ko0Q-1ybiA:
14.58
3ko0R-1ybiA:
14.58
3ko0S-1ybiA:
14.58
3ko0T-1ybiA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 1ybi NON-TOXIN
HAEMAGGLUTININ HA34
(Clostridium
botulinum) 		3 / 3 ASN A 195
ASN A 151
GLU A 143
 None
 0.76A 3kpdC-1ybiA:
undetectable		 3kpdC-1ybiA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1ybi NON-TOXIN
HAEMAGGLUTININ HA34
(Clostridium
botulinum) 		3 / 3 ASN A 195
ASN A 151
GLU A 143
 None
 0.76A 3kpdB-1ybiA:
undetectable		 3kpdB-1ybiA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 1ybi NON-TOXIN
HAEMAGGLUTININ HA34
(Clostridium
botulinum) 		5 / 12 ALA A 274
THR A 273
ASN A 178
LEU A 179
LEU A 161
 None
 1.18A 3r9cA-1ybiA:
undetectable		 3r9cA-1ybiA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 1ybi NON-TOXIN
HAEMAGGLUTININ HA34
(Clostridium
botulinum) 		4 / 8 SER A  63
THR A  17
TRP A  48
TYR A  29
 None
 0.80A 4drjB-1ybiA:
undetectable		 4drjB-1ybiA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0O_A_URFA303_1
(RRNA N-GLYCOSIDASE)		 1ybi NON-TOXIN
HAEMAGGLUTININ HA34
(Clostridium
botulinum) 		4 / 5 TYR A 201
ASN A 241
TYR A 250
ILE A 290
 None
 1.16A 4o0oA-1ybiA:
undetectable		 4o0oA-1ybiA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1ybi NON-TOXIN
HAEMAGGLUTININ HA34
(Clostridium
botulinum) 		3 / 3 ASN A 104
LEU A  11
PHE A 140
 None
 0.73A 5dsgA-1ybiA:
undetectable		 5dsgA-1ybiA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 1ybi NON-TOXIN
HAEMAGGLUTININ HA34
(Clostridium
botulinum) 		4 / 8 SER A  63
THR A  17
TRP A  48
TYR A  29
 None
 0.93A 5flcB-1ybiA:
undetectable		 5flcB-1ybiA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 1ybi NON-TOXIN
HAEMAGGLUTININ HA34
(Clostridium
botulinum) 		4 / 8 SER A  63
THR A  17
TRP A  48
TYR A  29
 None
 0.93A 5flcF-1ybiA:
undetectable		 5flcF-1ybiA:
13.36